基因改变细胞可以消除化学治疗引起的毒性作用

aoppolle

Gene-modified cells could protect against chemotherapy's toxic effects
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The usual doses of chemotherapy drugs can cause serious toxic effects in quickly dividing tissues such as the bone marrow.
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, f+ D$ N- R' |& r7 _8 u1 B2 _) }But now, researchers at Fred Hutchinson Cancer Research Centre suggest that one possible approach to reduce this toxic effect on bone marrow cells is to modify the cells with a gene that makes them resistant to chemotherapy.4 V/ ?2 o$ v' Q5 z6 Y9 r6 j

3 |, K6 u$ R* q  j5 o/ x4 r4 o: cHans-Peter Kiem and colleagues presented data from a clinical trial in which bone marrow stem cells from patients with brain tumors were removed and modified with a retrovirus vector to introduce the chemotherapy-resistant gene. The cells were then re-infused into the patients.
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In the trial, which was designed to evaluate safety and feasibility, patients were safely administered gene-modified blood stem cells that persisted for more than one year and did not show any apparent harmful effects.
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" k& @9 s" x" z/ A"Our initial results are encouraging because our first patient is still alive and without evidence of disease progression almost two years after diagnosis," Kiem said." C! m; z4 h/ F) [
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The results of the trial suggest the administration of the modified cells represent a safe method for protecting marrow and blood cells from the harmful effects of chemotherapy in brain tumor patients. 7 R9 y' n) g4 h# q

& Y) |' {* Z% L+ p% S0 D/ D8 lThe research was reported at the annual meeting of the American Society of Gene and Cell Therapy in Seattle.
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wys7416

化学毒性对细胞是种伤害，其破坏的基因是什么不清楚，但转染的基因可以修复这种损害，说明两者存在密切的关系，对于实践应用具有很大的帮助