基因改变细胞可以消除化学治疗引起的毒性作用

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Gene-modified cells could protect against chemotherapy's toxic effects
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8 I9 N) T" }% u6 N2 NThe usual doses of chemotherapy drugs can cause serious toxic effects in quickly dividing tissues such as the bone marrow.0 Y2 m/ \9 V* E7 ^3 q2 I+ a
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But now, researchers at Fred Hutchinson Cancer Research Centre suggest that one possible approach to reduce this toxic effect on bone marrow cells is to modify the cells with a gene that makes them resistant to chemotherapy.
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Hans-Peter Kiem and colleagues presented data from a clinical trial in which bone marrow stem cells from patients with brain tumors were removed and modified with a retrovirus vector to introduce the chemotherapy-resistant gene. The cells were then re-infused into the patients.
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- m% L3 s* P3 d. ]- D6 MIn the trial, which was designed to evaluate safety and feasibility, patients were safely administered gene-modified blood stem cells that persisted for more than one year and did not show any apparent harmful effects.3 l: W# {6 n$ i% z. y2 L) m" ]4 u

9 l- t0 w! Q* Q"Our initial results are encouraging because our first patient is still alive and without evidence of disease progression almost two years after diagnosis," Kiem said.
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) c9 {: ?$ a( t/ f( l6 O2 gThe results of the trial suggest the administration of the modified cells represent a safe method for protecting marrow and blood cells from the harmful effects of chemotherapy in brain tumor patients. $ h( L) E3 q" |" i0 a( v

/ @. f) L. Y- k& dThe research was reported at the annual meeting of the American Society of Gene and Cell Therapy in Seattle.
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wys7416

化学毒性对细胞是种伤害，其破坏的基因是什么不清楚，但转染的基因可以修复这种损害，说明两者存在密切的关系，对于实践应用具有很大的帮助