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本帖最后由 aspen 于 2009-8-31 09:53 编辑
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1 H( r" T4 w2 a* N! a0 j) dAnthony DeFranco
, d* G- _- ~. b/ E) QDepartment of Microbiology & Immunology, University of California at San Francisco
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. K( S% U+ s$ ~* iThemes include:
; [' |' m+ _- R8 T# j" ?) F1. Checkpoints in B cell development: feedback from Ig gene rearrangements
f' E5 T" v3 t2. Stromal environment/growth factors for B cell development
5 L0 _9 u- r2 Y3 \9 v D3. Lineage commitment: transcription factors and Notch signaling# p$ q) o+ M1 E* ?( V4 ^. N
4. Central tolerance of B cells/ E' t: b* w7 A3 C+ `
5. Peripheral tolerance of B cells3 @2 _4 D' o" \% Q- Q. ?$ x( ^# J
6. 3 different types of mature B cells: choice of cell fate and relative roles |
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