PPT:Themes in B cell development (UCSF)

aspen

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Anthony DeFranco* f4 u" f! h- [7 [
Department of Microbiology & Immunology, University of California at San Francisco
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" J; B* f5 p$ ?" q3 IThemes include:, A. p( Y5 T# }% i0 d! z
1. Checkpoints in B cell development:  feedback from Ig gene rearrangements# m) b% b& L$ d/ M/ X! o0 i/ S
2. Stromal environment/growth factors for B cell development/ f- n" u6 m- d2 |" g
3. Lineage commitment:  transcription factors and Notch signaling
% P8 K; h( s4 S' }4. Central tolerance of B cells
: q6 K' ~; h; a; C! P& `4 L+ o$ N5. Peripheral tolerance of B cells
6 z6 w7 r' j0 \+ y- a8 k) h( X6. 3 different types of mature B cells: choice of cell fate and relative roles

hualin840518

thanks

hughliang

非常感谢！
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rainsky1314

thanks very much !

刘子文

谢谢

beidouhan

好东西呢