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- 积分
- 760
- 威望
- 760
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- 1346
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Sean Morrison
3 ?+ P; ~1 ~% u( x' P2 d) z8 c1 _4 E3 V) rHoward Hughes Medical Institute Biography ; x, E! ^4 p8 d
American Society of Cell Biology Profile
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http://www.lsi.umich.edu/facultyresearch/labs/morrison/pi
) w, K& r1 _; l5 D: MSean Morrison is investigating the mechanisms that regulate stem cell function in the nervous and hematopoietic systems, particularly the mechanisms that regulate stem cell self-renewal and stem cell aging, as well as the relationship between stem cell self-renewal and cancer cell proliferation. Parallel studies of these mechanisms in stem cells from two different tissues will reveal the extent to which different types of stem cells employ similar or different mechanisms to regulate these critical functions.. r3 w4 v" |, b( ]+ y
, k# Z) c4 h% L9 y8 y) NIn addition to stem cell research, Dr. Morrison has been active in public policy issues surrounding stem cells as Director of the UM Center for Stem Cell Biology, an officer of the International Society for Stem Cell Research, and as a member of the American Society for Cell Biology Public Policy Committee. Michigan recently passed Proposal 2, making Michigan one of three states in the country to protect stem cell research in the state constitution.
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As a graduate student in Irving Weissman’s lab Morrison isolated and characterized blood-forming stem cells. As a post-doctoral fellow in the lab of David Anderson at the California Institute of Technology, Morrison developed techniques for the isolation of nervous system stem cells from uncultured tissues. In 1999, Morrison was recruited to join the U-M Medical School faculty as a Biological Sciences Scholar.
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The Morrison laboratory has published a number of discoveries related to the mechanisms that regulate the maintenance of stem cells throughout life, and how these mechanisms change during aging. For example, the Morrison laboratory’s work suggests that aging tissues exhibit reduced regenerative capacity partly because stem cells induce tumor suppressor mechanisms as they age, reducing stem cell frequency and function.
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Dr. Morrison was a Searle Scholar from 2000-2003, was named to Technology Review Magazine's list of 100 young innovators for 2002, received Wired Magazine's Rave Award for Science in 2003, and was given the Presidential Early Career Award for Scientists and Engineers by George W. Bush in 2003. More recently Dr. Morrison was awarded the McCulloch and Till Award by the International Society for Hematology and Stem Cells (2007), and the Harland Winfield Mossman Award by the American Association of Anatomists (2008).
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Dr. Morrison is a Howard Hughes Medical Institute investigator and has received funding from the National Institutes of Health, the Department of Defense, and various private foundations.
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' h; X4 x8 V& Z' @% cSelected Publications8 _! q' O' w' H8 E8 m
Kiel M.J., M. Acar, G.L. Radice and S.J.Morrison. 2009. Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. Cell Stem Cell 4:170-9.PubMed Link3 f% e( h3 z# v) A4 u2 G. w
Levi B.P., O.H. Yilmaz, G. Duester, and S.J. Morrison. 2009. Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood 113:1670-80.PubMed Link
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Quintana, E., M. Shackleton, M. Sabel, D.Fullen, T.M. Johnson, and S.J. Morrison. 2008. Efficient tumor formation by single human melanoma cells. Nature 456:593-598.PubMed Link (It is a very interesting paper, I will discuss it when I have time)
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8 o+ t5 t& ?3 A8 d4 xNishino, J., I. Kim, K. Chada, and S.J. Morrison. 2008. Hmga2 promotes neural stem cell self-renewal in young, but not old, mice by reducing p16 Ink4a and p19Arf expression. Cell 135:227-239.PubMed Link
0 \, h/ R O1 R# bKiel M.J., O.H. Yilmaz and S.J. Morrison. 2008. CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood 111:4413-4. PubMed Link
0 w& W8 k. M% HKiel, M.J. and S.J. Morrison. 2008. Uncertainty in the niches that maintain haematopoietic stem cells. Nature Reviews Immunology 8:290-301.PubMed Link& x2 Y7 I; X$ o
Morrison, S.J. and A. Spradling. 2008. Stem Cells and Niches: Mechanisms that promote stem cell maintenance throughout life. Cell 132:598-611.PubMed Link" p4 @* L) j/ A4 A
Joseph, N.M., J.T. Mosher, J. Buchstaller, P. Snider, P.E. McKeever, M. Lim, S. J. Conway, L.F. Parada, Y. Zhu, and S. J. Morrison. 2008. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 13: 129-140.PubMed Link
' F7 U% ^! c; d# WZhang, Y., S. N. Zolov, C.Y. Chow, S.G. Slutsky, S.C. Richardson, R.C. Piper, B. Yang, J.J. Nau, R.J. Westrick, S.J. Morrison, M.H. Meisler, and L.S. Weisman. 2007. Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proceedings of the National Academy of Sciences USA 104:17518-17523. PubMed Link% h g8 k7 L$ @2 @7 I2 X- l
Kiel M.J., S. He, R. Ashkenazi, S.N. Gentry, M. Teta, J.A. Kushner, T. L. Jackson and S.J. Morrison. 2007. Hematopoietic stem cells do not asymmetrically segregate chromosomes or retain bromodeoxyuridine. Nature 449:238-42. PubMed Link
6 B- }$ i" ]( q$ `( hKiel M.J., G.L. Radice and S.J. Morrison. 2007. Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cells 1:204-217. Cell Stem Cells Summary
- C, m- ?* i; S! lKim, I., T.L. Saunders and S.J. Morrison. 2007. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 130:470-483. PubMed Link
2 x& j B7 X0 a3 A8 sKim, I., He, S. H., Yilmaz, O. H., Kiel, M. J., & Morrison, S. J. (2006). Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood 108:737-744. PubMed Link
9 Y6 y: V. @" s% G+ NMolofsky, A.V., Slutsky, S.G., Joseph, N.M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N., & Morrison, S.J. (2006). Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443:448-452 PubMed Link0 x& t; G: y" F- O: {
Yilmaz, O. H., Kiel, M. J., & Morrison, S. J. (2006). SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 107:924-930. PubMed Link
% {( u! I( O; T6 ^, f$ `; k- h' |Yilmaz, O. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006). Pten dependence distinguishes hematopoietic stem cells from leukemia-initiating cells. Nature 441:475-482. PubMed Link
! ~6 [$ J) w! r- i! j2 G8 P. |Morrison, S. J., & Kimble, J. (2006). Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441:1068-1074. Nature 441:1068-1074. PubMed Link
) P9 C; |9 d X1 [: p9 E, [6 DMolofsky, A. V., He, S. H., Bydon, M., Morrison, S. J., & Pardal, R. (2005). Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16(Ink4a) and P19(Arf) senescence pathways. Genes & Development 19:1432-1437. PubMed Link
- R$ S3 U+ V: t- v+ H l( O7 a; i! H+ S: IKim, I., Yilmaz, O. H., & Morrison, S. J. (2005). CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells. Blood 106:903-905. PubMed Link
4 g1 B& A6 f3 M, @+ U# ]& u# Y0 kJoseph, N. M., & Morrison, S. J. (2005). Toward an understanding of the physiological function of mammalian stem cells. Developmental Cell 9:173-183. PubMed Link1 z |4 P. x6 g
Kiel, M. J., Yilmaz, O. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005). SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121:1109-1121. PubMed Link
" F& H0 k; @. q8 G' eKiel, M. J., Iwashita, T., Yilmaz, O. H., & Morrison, S. J. (2005). Spatial differences in hematopoiesis but not in stem cells indicate a lack of regional patterning in definitive hematopoietic stem cells. Developmental Biology 283:29-39. PubMed |
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发表于 2009-3-12 10:14
发表于 2009-3-12 11:23
