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http://www.jci.org/articles/view/64095
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& F; V& y3 t6 E2 UThe role of aging upon β cell turnover
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8 @  R0 p! X  L$ l' ZJake A. Kushner- V# P8 }* z, v' N: [

4 e( y1 [9 |1 `8 ^1 u8 {Published March 1, 2013$ F1 k3 P  P* u$ k7 u1 h9 A$ E$ U

% O; q% Q6 j0 f( e7 t; \  i0 _5 k( HPreservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes, thus fueling considerable interest in molecules capable of rebuilding β cell secretion capacity. Though early work in rodents suggested that regeneration might be possible, recent studies have revealed that aging powerfully restricts cell cycle entry of β cells, which may limit regeneration capacity. Consequently, aging has emerged as an enigmatic challenge that might limit β cell regeneration therapies. This Review summarizes recent data regarding the role of aging in β cell regeneration and proposes models explaining these phenomena.

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