Epigenetic -Magic & Focus research （最近两期Cell杂志封面）

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$ L# s7 ?/ C* z0 A# [题记：高山仰止，景行行止；虽不能至，然心向往之———司马迁《史记·孔子世家》（习近平主席给我们的教导）
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: Y% a2 D% u2 f/ Z. `#分享图片# 最新两期Cell杂志封面和相关研究聚焦（25 April, 2013 Volume 153, Issue 3 和 9 May, 2013 Volume 153, Issue 4）第一个封面来自全球十大顶级科学家——张毅，我的超级偶像，这张是内涵图，画的太牛了！生动，科学，直观地解释和呈现了现今生命科学界顶级研究热点，表观遗传学之DNA甲基化的最新研究进展和方向。第二个封面来自中国科学院生物物理所刘江研究员，剑桥超级大牛M. Azim Surani为这期的两篇研究论文配写了专题综述！
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On the cover 1: DNA methylation (5mC) patterns are established and maintained by DNA methyltransferases. Removing methyl modifications requires a multistep process. Iterative oxidation of 5mC by TET proteins generates 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC/5caC can be excised by thymine-DNA glycosylase (TDG) and repaired to regenerate unmodified cytosines to complete the methylation and demethylation cycle. In this issue, Shen et al. (pp. 692–706) provide a genome-wide view of iterative 5mC oxidation dynamics in mouse embryonic stem cells. Their results indicate that TET/TDG-dependent active DNA demethylation occurs extensively in the mammalian genome. In a related paper, Song et al. (pp. 678–691) look at the contribution of 5mC oxidized states to epigenetic tuning at regulatory elements. The cyclist on the cover illustrates the cyclic change of cytosine modifications. Artwork by Li Shen and Yi Zhang.6 _% d( C; k. |8 N: u1 p! t, c
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+ ]: j7 a+ l9 Z1 v3 G3 e; r3 wOn the cover 2: Genome-wide reprogramming of DNA methylation is a hallmark of embryogenesis and an important contributor to totipotency. In this issue, two studies from Jiang et al. (pp. 773–784) and Potok et al. (pp. 759–772) generate genome-wide methylome maps of zebrafish gametes and early embryos. Surprisingly, the sperm methylome remains largely unchanged until zygotic genome activation, and the oocyte undergoes a series of methylation-demethylation reprogramming cycles to ultimately match the patterns of sperm. The cover marks how offspring are found to inherit the DNA methylome of the sperm over the oocyte, highlighting the importance of the epigenetic regulation of embryogenesis. Cover art by Lan Jiang.
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7 J: Y8 N1 ~7 ~0 Y/ Ghttp://www.cell.com/home
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1. 张华林，肖遥，史蕾，吴灿杰，马凡华，王晓民，李文功，杨利国．哺乳动物DNA去甲基化的分子机制．中国畜牧兽医学会动物繁殖学分会第十六届学术研讨会论文集．哈尔滨，2012，135．5 m9 ]5 @% H6 }
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http://cpfd.cnki.com.cn/Article/CPFDTOTAL-ZGXJ201208004130.htm
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2. 肖遥，张华林，白莉雅，王晓民，李文功，杨利国. 哺乳动物中的DNA主动去甲基化. 遗传，2011，33（4）：298-306.
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   http://www.cnki.com.cn/Article/CJFDTOTAL-YCZZ201104005.htm( h6 ~0 D9 l1 M( [

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该文也可见于作者科学网博客：
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9 Y& w' ~6 K" o% S# |, s& G* @http://blog.sciencenet.cn/home.p ... =blog&id=690535& G. X! e& C: M: V* I8 @  X- v! Z

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