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* ^. o5 a h9 w& f6 y2 A7 AVolume 78, Issue 4On the cover: Neural networks control 9 Z% J2 M( A0 D+ ~% {( H: X
intrinsic encoding of the circadian clock. Circadian pacemaking in the
# u$ p2 M5 U5 U) H$ d5 U& msuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and
. f) B- O) i' e# Kintercellular properties, with the latter still poorly understood. In this issue
; L% K9 r: x" O& Pof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level ]7 r1 i* H* h+ |) a
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
9 A; B2 y, r7 u6 Y: B! g0 Vrestricted SCN neuronal subpopulations reprograms encoding of circadian time by ( C& {& j* Z( p6 m
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic 6 t) L% w' r- ?4 ?* l% i1 q- ~) ?
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna ; A+ U/ V) `& E1 {8 w
Westmoreland.& B# c+ r2 u' q
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发表于 2013-5-23 23:46
