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Volume 78, Issue 4On the cover: Neural networks control 8 [. A, i' G* p, f4 E% |
intrinsic encoding of the circadian clock. Circadian pacemaking in the
; Z Q8 e6 v# O# C7 Isuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and
0 y7 N3 j( q$ h! Y( jintercellular properties, with the latter still poorly understood. In this issue : _/ O: a0 x/ Q( n7 z+ d. O
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level : Z, g/ c& a7 J5 N( E6 H* ?) u+ |
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
6 O, b8 h; Z" |restricted SCN neuronal subpopulations reprograms encoding of circadian time by
) u. ?7 N; T. p N9 Kthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
; U9 C0 C. @, Q6 Q$ p) b; T, |0 E% bconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna
* ?8 h7 D- o! }/ v, RWestmoreland.
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发表于 2013-5-23 23:46
