![Rank: 8](static/image/common/star_level3.gif) ![Rank: 8](static/image/common/star_level3.gif)
- 积分
- 17983
- 威望
- 17983
- 包包
- 26159
|
& b" G% x9 a' m# ^5 m , W. z- l* v- t" z- Y4 D) |" \' l) u
Volume 78, Issue 4On the cover: Neural networks control 8 [. A, i' G* p, f4 E% |
intrinsic encoding of the circadian clock. Circadian pacemaking in the
; Z Q8 e6 v# O# C7 Isuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and
0 y7 N3 j( q$ h! Y( jintercellular properties, with the latter still poorly understood. In this issue : _/ O: a0 x/ Q( n7 z+ d. O
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level : Z, g/ c& a7 J5 N( E6 H* ?) u+ |
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
6 O, b8 h; Z" |restricted SCN neuronal subpopulations reprograms encoding of circadian time by
) u. ?7 N; T. p N9 Kthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
; U9 C0 C. @, Q6 Q$ p) b; T, |0 E% bconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna
* ?8 h7 D- o! }/ v, RWestmoreland.
) F) H ~" a! t' _# P) B! z: U6 C7 U# I1 i
|
-
总评分: 威望 + 20
包包 + 20
查看全部评分
|