《细胞》[Cell]13年4月25日出版pdf全文

nero1981

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Volume 153, Issue 3
- W5 y5 q/ T; h8 Z/ g% y2 tOn the cover: DNA methylation (5mC) patterns are established and maintained
" g  D* q. D  G+ Zby DNA methyltransferases. Removing methyl modifications requires a multistep / P, k$ x+ N. q& @5 Z
process. Iterative oxidation of 5mC by TET proteins generates
) V1 T$ w! M8 v5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine ) I# r& @9 O* \3 F7 t+ O
(5caC). 5fC/5caC can be excised by thymine-DNA glycosylase (TDG) and repaired to # O& P- C: Z8 ~! x( W. T9 A8 m: i7 [
regenerate unmodified cytosines to complete the methylation and demethylation
/ t/ r" A) Z% s4 Y, e) Ocycle. In this issue, Shen et al. (pp. 692–706) provide a genome-wide view of * n  c, k; e6 L) m) R1 }
iterative 5mC oxidation dynamics in mouse embryonic stem cells. Their results
  y3 Y* x. S" x+ z' [indicate that TET/TDG-dependent active DNA demethylation occurs extensively in
9 D9 o% m% s. \7 ^( S. bthe mammalian genome. In a related paper, Song et al. (pp. 678–691) look at the
' i% l3 [) ~7 w0 v1 Ncontribution of 5mC oxidized states to epigenetic tuning at regulatory elements.
" L: g' ^& c2 V; wThe cyclist on the cover illustrates the cyclic change of cytosine & L9 u. e* h( k; p4 o
modifications. Artwork by Li Shen and Yi Zhang.
9 U5 |7 I6 h' u. K& k& I# k# y[hide][/hide]

懵懂干细胞

辛苦了

yuheng

谢谢

exin11

86964109

谢谢^^

nydfy

thanks

小小元分

kouke80

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vivipet

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tpwang

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5 z% W" i2 N! p1 P4 h6 athanks