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本帖最后由 细胞海洋 于 2012-9-5 22:58 编辑 1 O5 y( K O6 M$ c. ]* F
5 o6 x; `* A1 i% N1 s低剂量抗生素怎样增加体重
4 ~) Q" g6 a9 c% gNature 488 (7413)
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* W/ j: D3 `% s8 T+ L1 W 连续使用低剂量抗生素几十年来一直被用来增加牲畜的体重，但这一效应背后的机制尚不清楚。通过在年轻小鼠身上采用类似方法，本文作者发现，低于治疗剂量的抗生素能增加身体的脂肪量，使小肠微生物群落的组成发生变化，改变导致短链脂肪酸生成的微生物代谢通道的活性。这些发现凸显了某些微生物在维持正常代谢活动中的重要性。
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9 A# U( y0 y! T; b; |; q$ AAntibiotics in early life alter the murine colonic microbiome and adiposity
) u- o0 ^' i8 m: G l; eIlseung Cho,1, 2 Shingo Yamanishi,1 Laura Cox,3 Barbara A. Methé,4 Jiri Zavadil,5, 6 Kelvin Li,4 Zhan Gao,3 Douglas Mahana,3 Kartik Raju,3 Isabel Teitler,3 Huilin Li,7 Alexander V. Alekseyenko1, 6 & Martin J. Blaser1, 2, 3 & z1 p+ F, ~# f& b) z3 I# t' k* t
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Abstract
9 V; R) v P& P( g2 HAntibiotics administered in low doses have been widely used as growth promoters in the agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because antimicrobial agents of different classes and varying activity are effective across several vertebrate species, we proposed that such subtherapeutic administration alters the population structure of the gut microbiome as well as its metabolic capabilities. We generated a model of adiposity by giving subtherapeutic antibiotic therapy to young mice and evaluated changes in the composition and capabilities of the gut microbiome. Administration of subtherapeutic antibiotic therapy increased adiposity in young mice and increased hormone levels related to metabolism. We observed substantial taxonomic changes in the microbiome, changes in copies of key genes involved in the metabolism of carbohydrates to short-chain fatty acids, increases in colonic short-chain fatty acid levels, and alterations in the regulation of hepatic metabolism of lipids and cholesterol. In this model, we demonstrate the alteration of early-life murine metabolic homeostasis through antibiotic manipulation.
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链接：http://www.nature.com/nature/jou ... ll/nature11400.html' Z' h I0 K. K# {9 W! M
! r( |% ]+ T2 X& s( V2楼原文 感谢zorro 提供 |
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发表于 2012-9-4 10:02
发表于 2012-9-4 18:40
，好东西，怎么快速检测残留？