《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3
/ G/ ~- M: O! G" [7 t7 ~On the cover: The combined activity of neurons in the brain generates
# U$ n1 m+ H- E0 joscillatory rhythms, or “brain waves,” that can be detected by
6 l- K7 y" ~9 \  `6 q: Melectroencephalographic recordings. Verret et al. (pp.708–721) found that these
  Q4 @' _0 ]6 M- Xbrain waves, which are represented on the cover by an undulating pattern, are ; R) r# ^9 A3 L: q& {* P6 q
altered in mouse model of Alzheimer's disease (AD), and the changes are linked
9 d6 q% r0 N* @: {to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
4 A; F4 x9 t: q9 ^, [$ b) xNav1.1 levels specifically in inhibitory interneurons improves oscillatory
& f# ~8 v! h- n  f+ f( r2 orhythms and memory in AD mice, offering a new therapeutic approach for
6 n( q4 _( v+ o; J$ r+ X- s, J& Mpotentially treating cognitive disorders. The image was created by Arantxa
7 `. i3 h, u; z# Z. }Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
) @: g; K, ^( h% u; X9 W! a$ u(electronic recreation).
' C# o3 F9 S' r( _- N4 g[hide][/hide]

menghy

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