小档案：Cartistem——全球首个异基因干细胞药物

sunsong7

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( f: }, }! Y9 @+ c2 N$ UCartiStem是全球首创的异基因干细胞药物，用于植入治疗关节软骨缺损。许多患有关节炎的人需要进行膝人工关节置换术。早期应用该产品在阶段可延迟或甚至不需要进行人工膝关节置换术。
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/ _/ ?7 m7 ?1 Q% @0 V商品名：Cartistem+ S: x! N' G) O
通用名：间充质干细胞（脐带血来源）
6 M6 k( U/ N9 d7 r6 V) `" k适用范围: 退行性关节炎(Other musculoskeletal agents ，treating degenerative arthritis and knee cartilage defects). 2 C4 [' O+ ~  h
生产商：韩国汉城Medipost Inc.# [0 h, k- g- w5 g% H% ?1 O
批准部门：韩国食品药品监督管理局（KFDA）: L: T& C' c3 e9 O( k
批准日期：2012年1月19日) q- @2 |6 @" N, X" W* d
Cartistem研究进展：
' I! @/ k1 `* s; N; fCartistem临床研究： http://www.stemcell8.cn/thread-51573-1-1.html
4 |" Z4 l- V0 CMEDIPOST背景资料：  
2 o1 Q1 ^* n7 g, M: vMEDIPOST is committed to providing cord blood banking services and innovative adult stem cell drugs. Umbilical Cord Blood (UCB) - or simply referred to as 'cord blood', is the blood remaining in the newborn's umbilical cord after birth, and it can only be collected at the time of birth. 2 W; u6 e: C9 ]8 w7 ~- c* L

* L: g. q# b* W" s; D' uCord blood banking is about collecting and storing stem cells from the newborn's umbilical cord. The cord blood is a rich, non-controversial source of stem cells that have been shown to be effective in treating nearly 80 different life-threatening conditions. ! O' X  H1 v! H/ R) ]
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Stem cells known as Mesenchymal Stem Cells (MSCs) are isolated from publically donated cord blood and these human Umbilical Cord Blood-derived MSCs (hUCB-MSCs) are used to develop adult stem cell drugs that can give hope to patients with an incurable disease. Because these hUCB-MSCs have a special 'immune-privileged' characteristic, stem cells from an unrelated donor can be used to treat conditions of any patient, without concerns of immune-rejection.
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Using the state-of-the-art stem cell processing and culturing technology together with a dedicated team of over 50 scientists, MEDIPOST is striving to lead a new era of Regenerative Medicine. With over a decade of R&D investment on cutting-edge stem cell technology, MEDIPOST is proud to bring world's first hUCB-MSC based drugs into the market which we believe will revolutionize today's medical care.
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Human Umbilical Cord Blood - Mesenchymal Stem Cells (hUCB-MSC) are free from ethical controversy which may arise during clinical and commercial development of stem cell drugs. We obtain hUCB-MSCs from the cord blood, which is regarded as medical waste despite the fact that it has been used for hematopoietic stem cell transplantation (HSCT) for over two decades. Use of cord blood has been proven to be safe with over 140,000 cases of HSCT performed world- wide without any occurrence of teratoma. , C' I$ v' z( M- R
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hUCB-MSCs possess excellent proliferation capacity with ability to differentiate into multiple types of cells or tissues. They are immune-privileged and thus their allogeneic use does not cause adverse immune reactions. hUCB-MSCs harvested from cord blood show the lowest levels of immunogenicity compared to those by other types of adult stem cells. In fact, instead of provoking the immunogenicity, they rather modulate the adverse immune reactions within the host and therefore making hUCB-MSCs an ideal candidate for mass-producible stem cell drug for allogeneic use. : q' F# x! i; z2 }% I
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MEDIPOST's capability for standardized processing and mass-production of hUCB-MSCs allows manufacture of "off-the-shelf" adult stem cells drugs. MEDIPOST has conducted many pre-clinical studies and clinical trials demonstrating the safety and efficacy of hUCB-MSCs as therapeutic adult stem cell drug for medicinal use.
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$ R' F  D5 K" f) A【参考文献】
: u2 ]2 F7 v8 G: J1. Galectin-3 secreted by human umbilical cord blood-derived mesenchymal stem cells reduces amyloid-beta42 neurotoxicity in vitro. http://www.ncbi.nlm.nih.gov/pubmed/20655311
6 a+ R' J/ z6 A( C# E2. Irradiation enhances the tumor tropism and therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand-secreting human umbilical cord blood-derived mesenchymal stem cells in glioma therapy. http://www.ncbi.nlm.nih.gov/pubmed/20945331+ S4 u) r3 C. i2 T2 H5 |  ^
3. Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation. http://www.ncbi.nlm.nih.gov/pubmed/20471717
  |! _# r5 ^# O( f! g* @' G4. Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats. http://www.ncbi.nlm.nih.gov/pubmed/19500472  Y3 I8 g  }( V; l- ^
5. Immunological properties of umbilical cord blood-derived mesenchymal stromal cells. http://www.ncbi.nlm.nih.gov/pubmed/18495100
4 j1 x( t2 a1 u: e- f3 P  ^6. GD2 expression is closely associated with neuronal differentiation of human umbilical cord blood-derived mesenchymal stem cells. http://www.ncbi.nlm.nih.gov/pubmed/20165901  A4 Q& A& E; q2 K
7. Efficient intracytoplasmic labeling of human umbilical cord blood mesenchymal stromal cells with ferumoxides. http://www.ncbi.nlm.nih.gov/pubmed/18088004
  {; g4 G: N6 \% _8 X5 N3 [  q& `8. Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma. http://www.ncbi.nlm.nih.gov/pubmed/19047138
5 J3 C2 v+ G7 M' R- q9. Mesenchymal stem cells feeder layer from human umbilical cord blood for ex vivo expanded growth and proliferation of hematopoietic progenitor cells. http://www.ncbi.nlm.nih.gov/pubmed/16391912
8 J" c* o- u3 @. j7 s2 T10. Mesenchymal stem/progenitor cells developed in cultures from UC blood. http://www.ncbi.nlm.nih.gov/pubmed/15512914" {4 z$ `) ^1 ]' b

0 h) P* I/ r& k【相关报道】
" ^  s# S  V6 q. y8 v法新社：韩国批准销售新的干细胞药物 http://www.stemcell8.cn/thread-51572-1-1.html
1 n( D4 R+ C6 S  s9 N0 }7 k  @韩国：世界第二例干细胞药物将获批生产 http://www.stemcell8.cn/thread-51229-1-1.html
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（根据网络信息整理）

subenjinwo

不错呢。