spchsq 发表于 2012-1-8 10:57 , a8 K, C- a2 U4 E
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Stem cells could hold key to 'stopping ageing' say scientists after trial triples mouse lifespan
( [5 Z4 G$ ~4 l% u2 ^; n0 } c- [size=1.4em]Lifespan tripled after injection of cells from young mice
- [size=1.4em]Injection made mice grow bigger and stronger
- [size=1.4em]Effect on ageing-disorder cells even works in lab dish
4 {( e; P/ U- T7 X- M - [size=1.4em]Could hold key for injections that offer humans 'youthful vigor'
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5 S* @, ]3 ^3 V8 j) ZBy Rob Waugh
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4 @, H5 a( p- ?4 t9 g; z+ `Last updated at 8:24 AM on 4th January 2012& @8 E7 E9 o3 R3 f7 O; W
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* ~& r9 @& A! F& z3 O An experiment proved that a single injection of stem cells could make mice live three times as long. Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings 9 F& B4 J: g! X" H2 v7 V) [
[size=1.2em]Stem cells can halt ageing - and even prolong lifespans up to three times, scientists say.
1 i' z: b4 D5 C6 T1 Z( r[size=1.2em]An experiment proved that a single injection of stem cells could make mice live three times as long.5 |8 N) v2 Q0 _: G/ `. h
[size=1.2em]The injection also made the mice grow bigger and stronger.
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[size=1.2em]Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings.
! I9 ]# c. z, M- f0 R1 A6 z[size=1.2em]The researchers, from the University of Pittsburgh,[size=1.2em]say further research could help us hold off the ageing process altogether. 8 v. d" j0 x! ~4 ?$ [3 j- s6 A
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[size=1.2em]The effect was even visible on cells in a lab dish where young stem cells were placed next to prematurely ageing cells.
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8 f- n5 O5 c1 I4 \9 g* {1 U[size=1.2em]The sick, ageing cells performed better after being placed next to the healthy ones. 3 a& ?; k. c3 R0 {) q- e1 b
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[size=1.2em]The U.S. researchers conducted experiments on mice modified to age prematurely, a condition known as progeria. + [1 |# ~! C. k/ f: ?# u. Z
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[size=1.2em]Progeria also occurs in humans.
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/ A6 k2 P# t1 i4 C* N% h5 K[size=1.2em]Giving these mice shots of stem cells from young, healthy counterparts allowed them to live up to three times longer than those with progeria.
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5 r0 Z, K/ c# p4 B% U" a% ~[size=1.2em]Their experiment saw them first study the stem cells of the progeria sufferers.
3 i* O/ t" c1 \3 t+ V+ C7 T# Z[size=1.2em]The scientists saw there was a difference between the cells in the mice with the ageing disorder - they had fewer, the ones they had regenerated less quickly than ordinary mouse stem cells. - r2 ^2 u8 a, T& z3 U9 K" `1 G
9 H$ P3 l3 ~- y. _$ r" l' h[size=1.2em]However, injecting stem cells into 17 day-old mice saw a huge increase in their lifespans - from an average of just 21-28 days to more than 66 days, three times longer than usual.
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[size=1.2em]The modified mice given stem cell shots grew almost as large as their healthy counterparts and grew new blood vessels in their brains and muscles. $ y9 t# t% y4 N1 `
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Stem cells can halt the signs of ageing - and even prolong lifespans up to three times, scientists say. An experiment proved that a single injection of stem cells could make mice live three times as long
: c0 H ?) R0 x[size=1.2em]'The mice were healthier and lived longer after an injection of stem cells from young, healthy animals,' said Dr Laura Niedernhofer
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! R$ r2 f6 D u" V[size=1.2em]Scientists think this is because the healthy stem cells helped correct abnormalities in the cells of the rapidly-ageing mice. # T: C: J% R, F) M: M8 n5 {
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[size=1.2em]Study author Dr Laura Niedernhofer, whose findings were published in journal Nature Communications said: 'Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals.'/ o1 L# T3 |! O) G
8 \8 t7 y' o3 r3 l6 G6 v[size=1.2em]'That tells us that stem cell dysfunction is a cause of the changes we see with aging.' She added: 'As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly. % `& V' T7 {9 O7 t- P5 X
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[size=1.2em]'Affected mice that got a shot of stem cells just before showing the first signs of ageing were more like normal mice, and they grew almost as large.'
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9 s1 ~0 l$ L) D[size=1.2em]'Closer examination showed new blood vessel growth in the brain and muscle, even though the stem/progenitor cells weren’t detected in those tissues.
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E1 M$ l9 @1 Z! V" |4 Z[size=1.2em]'In fact, the cells didn’t migrate to any particular tissue after injection into the abdomen. ' G N+ X& M6 ^9 G7 ]
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[size=1.2em]“This leads us to think that healthy cells secrete factors to create an environment that help correct the dysfunction present in the native stem cell population and aged tissue.6 @1 n+ ?. \- {3 Q
[size=1.2em]'In a culture dish experiment, we put young stem cells close to, but not touching, progeria stem cells and the unhealthy cells functionally improved.'
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Read more: http://www.dailymail.co.uk/sciencetech/article-2081734/Stem-cells-hold-key-stopping-ageing-say-scientists-successful-mouse-trial.html#ixzz1iqRTmx7I |