VEGF在肿瘤发生阶段的作用

syapxlg

大量的研究表明，VEGF在很多肿瘤的发展演化中起关键作用，但是否是肿瘤发生的始动因素尚待研究？？各位网友是否有相关的见解，请多多讨论!!

monroelml

肿瘤由潜伏期到恶化期，需要足够的养分，氧气，因此血管新生（angiogensis）是这种转化中的很重要的一步。血管新生过程中，有很多细胞因子参与，包括FGF, 以及你提到的VEGF。我感觉VEGF不是肿瘤发生的始动因素，而是恶化的始动因素。现在有利用anti-angiogensis therapy来治疗肿瘤,使用angiogensis inhibitors来抑制血管新生，从而控制肿瘤的恶化过程。我不是研究肿瘤的，但是最近读到一些有关angiogensis的文章，不知道我的理解是否正确，希望大家一起来讨论！

zhanglianglu

Lactate: a metabolic key player in cancer.
3 J& T4 N7 _& k$ pIncreased glucose uptake and accumulation of lactate, even under normoxic conditions (i.e., aerobic glycolysis or the Warburg Effect), is a common feature of cancer cells. This phenomenon clearly indicates that lactate is not a surrogate of tumor hypoxia. Tumor lactate can predict for metastases and overall survival of patients, as shown by several studies of different entities. Metastasis of tumors is promoted by lactate-induced secretion of hyaluronan by tumor-associated fibroblasts that create a milieu favorable for migration. Lactate itself has been found to induce the migration of cells and cell clusters. Furthermore, radioresistance has been positively correlated with lactate concentrations, suggesting an antioxidative capacity of lactate. Findings on interactions of tumor metabolites with immune cells indicate a contribution of lactate to the immune escape. Furthermore, lactate bridges the gap between high lactate levels in wound healing, chronic inflammation, and cancer development. Tumor cells ensure sufficient oxygen and nutrient supply for proliferation through lactate-induced secretion of VEGF, resulting in the formation of new vessels. In summary, accumulation of lactate in solid tumors is a pivotal and early event in the development of malignancies. The determination of lactate should enter further clinical trials to confirm its relevance in cancer biology.
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meihai08

VEGF在很多肿瘤的发展、演化中起关键作用，至于它与肿瘤发生而言，VEGF不一定有特别的作用，因为肿瘤发生后，由小逐渐生长变大，组织中的氧不足以满足肿瘤细胞生长时，肿瘤会作出反应，刺激细胞释放VEGF等因子，促进肿瘤周围血管的生成，为肿瘤提供生长所需的氧及其他有关生长的因子。血管生成后，又为肿瘤的转移提供了途径------肿瘤细胞通过血管迁移。