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In additional mating studies we have conducted (as yet unpublished)6 r+ z! t3 C5 x) e% ]9 e9 \
using wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous
8 k, ?! N( z$ S+ s( @+ s! I( Vbreeding assay following heat shock. Results from these* z, j3 x! G* T9 Q/ k9 B/ @
experiments separate the histopathologic lesions in early% ^) | G! Y, X7 f1 X/ ^! ]4 i
and late spermatogenic stages (i.e., apoptotic spermatocytes),
% M& X& h) F! T1 M& P3 Uwhich are dependent on HSF1 and inducible HSP8 O1 E7 c: R. W
expression, from longer-term effects on reproductive performance
- g3 B }/ Y$ V; drelating to spermatocyte-specific but stage-independent
p/ |2 B1 W) S4 a7 d; Feffects.% L: Y7 }8 F! [3 w
来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,: @) B: V, g, V# Z7 P
and Fertility in Adult Male Mice。6 [! J0 {6 F6 }" z& D/ K* G
236页删划线部分# C, u$ c, _6 c9 U$ c2 {4 \' |( b
9 K) V* @' F. b4 a2 a
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