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2 t7 S9 s. V& T, R5 ICancer Stem Cell Niche: The Role of Mesenchymal Stem Cells in Tumor Microenvironment
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Source: Cancer Stem Cells - The Cutting Edge! b/ u! c6 V! b% w+ n
ISBN 978-953-307-580-8
' }4 [! T/ e& X' x; @) ZEdited by: Stanley Shostak
+ |" q- a O- V% l" w( wPublisher: InTech, August 20112 N# B/ U% _; X2 q" Q0 K* ?6 E
Conclusions
$ L# \8 \+ c6 [/ ^Pro-tumorigenic contribution of MSCs is still not fully uncovered. This is in part explained by the presence of heterogeneous population due to the lack of exact definition of MSC population, and the complexity of their intera ction with tumor cells and the large range of cytokines and growth factors. However, a number of evidences suggest that MSCs are actively recruited into tumor site, and contribute to tumor microenvironment as either themselves or as the tumor-associated fibroblast s. They directly or indirectly regulate tumor cell proliferation, differentiation, immune tolerance, angiogenesis, metastasis and drug resistance through the interaction with numero us cytokines and growth factors as well as providing niche to the cancer cells or cancer stem cells in cooperated with ECM. Although MSCs can be friends or foes of tumor cells, depending on their constituents of population including the origin and stage of differentiation and also the type of tumor cells to be interact with, further investigation will define the role of MSCs in tumor progression that leads to novel strategy for cancer therapy.
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