T细胞的免疫反应水平决定干细胞的再生能力

sunsong7

老狼以为干细胞移植受体存在一个“机会窗口”问题——炎症反应是决定细胞植入的关键，下面文章认为干扰素γ和肿瘤坏死因子α表达水平影响干细胞对组织的修复作用。7 e0 J, y# F  x; `8 _  f! [

: l6 ]' |9 G* k. R/ z' iRecipient's Immune System Governs Stem Cell Regeneration
' N# F6 A4 K" U$ s; nScienceDaily (Nov. 20, 2011) — A new study in Nature Medicine describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance of the transplant recipient's immune system in stem cell-based regeneration., _- {* L. F& V3 ^$ {+ C2 f

; K* N: j! f7 Q/ N0 d6 [$ n! S$ b. O, J. b' X3 ?9 }- w# {1 v% b, z
--------------------------------------------------------------------------------* f- Z  D% N! q) h  @
( |0 x4 F3 X) |& e: r
The study, conducted at the Center for Craniofacial Molecular Biology at the Ostrow School of Dentistry of USC, examined how mice with bone defects responded to bone marrow mesenchymal stem cell (BMMSC)-mediated bone regeneration.. C7 x# }% o. h7 V. A% h4 b

* O, G0 B" y+ k3 p9 G, vUnder normal conditions, the mice's T-cells produced an inflammatory response and triggered the creation of cytokines interferon (INF)-gamma and tumor necrosis factor (TNF)-alpha. These attacked and killed the stem cells, preventing the production of new bone.
4 ]: _& E5 @0 z( Z2 ^; u* i  r0 c# z$ A
"Normally, T-cells protect us from infection," said Professor Songtao Shi, corresponding author for the study, "but they can block healthy regeneration from happening."& ?! p1 l, U& G9 ?, E" w5 L* ~6 A& v

* m, @$ w( x1 N: Q+ A+ UHowever, when the mice were given infusions of regulatory T-cells (Tregs), the levels of the interfering INF-gamma and TNF-alpha decreased, increasing the rate of bone regrowth and defect repair. Furthermore, administering the anti-inflammatory drug aspirin at the site of the bone defect also increased the rate at which the BMMSCs were able to regrow bone.8 R1 g4 ?9 `0 w- N% D6 \

! n2 k" [' ]3 H8 cPostdoctoral Research Associate and lead author Yi Liu said the findings illustrate the previously unrecognized role of T-cells in tissue regeneration. They also highlight the need for scientists exploring the possibilities of stem cell-based regeneration to shift their focus to the immune system, she added.. }2 j  o; R' b4 }
: t9 E! f8 q( S6 f1 D1 y$ h
"Based on what we've found, this should be the direction of more research in the future," Liu said.
! N) r7 m3 Y' N8 ]4 a8 O
$ `. H- q" m  g3 d# W* D/ shttp://www.sciencedaily.com/releases/2011/11/111120134749.htm& E4 g7 W0 o4 U1 U$ ]/ g

2006goodluck

MAKER

wwk865

求原文啊
. q" s) p8 @% h4 |http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2542.html

wwk865

好吧。。。我有权限

晏子

学习！~
1 z( p+ R/ M3 F( e

wind789

多谢。我为何发布不了附件？

一一

这是一篇实用性的文章，异源性细胞注射一定会产生炎症反应，而个体差异不同，种属不同，反应程度就不同。而我们最关心的就是治疗人类疾病时，干细胞的修复水平会受到哪些因素的干扰，至今我们都不太清楚，也少有人去研究，而这恰恰是干细胞产业化必须要解决的有效性问题，是大众普及，还是分门别类，还是因人而异，而这在其中起着关键作用的靶分子是什么，水平如何，怎样选择，或者在干细胞治疗的同时是否应有辅助性增效的手段，这个问题是个问题，希望大家多多讨论哦！

naturalkillerce

# w& l  Q* ~1 v
5 t: W6 m  @  {. V1 }  A) }5 b% O回复 sunsong7 的帖子) y' t  }: n; u

4 Y0 j* F- p! r, b" u是不同类型的T细胞造成的，有些T细胞促进细胞因子INF-γ和TNF-α产生引发炎症反应，而有些T细胞，如调节性T细胞，抑制这些细胞因子产生。当移植干细胞时，身体存在一种博弈，哪种类型T细胞占上风，就决定移植成功还是失败。
6 @$ z% C- L- D) Y, M& E; c
# X9 e* l1 q5 k; m该新闻全部编译，参见：9 s+ }; r1 n& [6 y: t
美科学家发现受者免疫系统控制着干细胞再生：http://www.stemcell8.cn/thread-49629-1-1.html

zxcv12345

回复 sunsong7 的帖子
/ v2 Q$ @. ~! |$ [/ N+ t* H9 x* E/ }( f+ N( ~1 \9 z8 E
干细胞和免疫细胞的作用是相互的，羊膜干细胞可以抑制T细胞，现在又报道T细胞可调节干细胞分化，看来干细胞和免疫的关系大有可为

biowish-yuan

学习了