求关于小分子在iPSCs诱导过程中的作用有关文献

genedu

各位大虾，谁手里有关于替代OCT4，SOX2，Klf4，c-Myc这四个因子以及其他诱导因子的小分子的文献？小弟拜谢了6 \5 e' x1 ?1 J7 K
如果有哪位神人实际操作过的，请告知小分子名称及其用量。
" h( L6 c5 o! x3 \4 c5 p# ?; @! A再次拜谢

cellbuddies

可以参考丁盛的文章，给你一个文章列表
( l* b' d, F8 V* B- UGeneration of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors3 H2 H8 a# x/ i1 S3 j
Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming0 H' j1 q6 K( y' d) \- s6 R  p
A chemical platform for improved induction of human iPSCs-supplemental methods and data: q0 W( T9 j0 ~! O0 ~
还有University of Cambridge的Austin Smiths
! A: Z9 j7 n) y- p, j' pPromotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

cellbuddies

full text

cellbuddies

MEK inhibitor PD0325901 (Sigma, 0.5 μM)
2 u' G5 y- M- N- W3 NALK5 inhibitor A-83-01 (Tocris Bioscience, 0.5 μM)7 x  w  A9 i  x& D  w( P; t7 c/ n
GSK3β inhibitor CHIR99021 (BioVision, 3 μM)) L* ^% w; A- K0 j8 _5 X
挺贵的，大概5000大洋

genedu

回复 cellbuddies 的帖子4 E/ }, Z* ?3 }0 y2 Y# Y
  ^, K* N9 [9 T3 b% e4 S
真是太感谢了。临帖涕零，不知所言