1998-nature-Dendritic cells and the control of immunity

andylee824

   B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic
) A4 j6 `) a/ O& H* Z. Wcells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to
' V- }7 j  l7 n# n% e# ?2 I- ^lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also0 I- D! T) M0 C7 Q- {
tolerize Tcells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once( h+ f, m5 P9 s) B$ N% F& X+ g
a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell
( Q; F+ r. W( ~5 M8 l5 M- C: Ibiological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the4 N- @, u3 {2 l4 }  H# v
immune system.

andylee824

自己顶一下！

andylee824

自己顶一下！