细胞重编程的进化生物学

botizhou

tpwang

& ~" O  M5 n7 u, h7 {
' m) Q# @) |5 A回复 botizhou 的帖子( H* F9 j+ ], t4 y- W
9 h% A2 P% k/ |2 n& h7 X4 \
这一期皇家学会生物学会刊是关于重编程和干细胞的，Ian Wilmut这篇是个引言。一系列文章都由本领域的名人写，包括亚马纳卡，丁盛，George Q. Daley，Melton等，都比较侧重perspectives，有些观点应该有参考价值。能否下来分享一下。
. w6 o5 E5 L; j% M  h& T) x7 h
; ~' b: y6 D" b" Xhttp://rstb.royalsocietypublishing.org/content/current3 j& n; `4 C( z) a% r: h& D

3 H5 `1 _0 I/ ~丁盛关于小分子与干细胞的文章：
' F  T" j- }0 \) C' b% m1 c- m( [' W8 `2 J% w3 J! t
The evolving biology of small molecules: controlling cell fate and identity
/ A. R, c- a0 Z. p0 I- m* J7 P9 y1 k$ S8 V
Abstract6 F+ _( f4 s. W0 m. B9 ^6 f, A8 B
* w: t1 p. {! F3 y3 U6 z
Small molecules have been playing important roles in elucidating basic biology and treatment of a vast number of diseases for nearly a century, making their use in the field of stem cell biology a comparatively recent phenomenon. Nonetheless, the power of biology-oriented chemical design and synthesis, coupled with significant advances in screening technology, has enabled the discovery of a growing number of small molecules that have improved our understanding of stem cell biology and allowed us to manipulate stem cells in unprecedented ways. This review focuses on recent small molecule studies of (i) the key pathways governing stem cell homeostasis, (ii) the pluripotent stem cell niche, (iii) the directed differentiation of stem cells, (iv) the biology of adult stem cells, and (v) somatic cell reprogramming. In a very short period of time, small molecules have defined a perhaps universally attainable naive ground state of pluripotency, and are facilitating the precise, rapid and efficient differentiation of stem cells into somatic cell populations relevant to the clinic. Finally, following the publication of numerous groundbreaking studies at a pace and consistency unusual for a young field, we are closer than ever to completely eliminating the need for genetic modification in reprogramming.
9 b- P4 z, S" K) I# M