本帖最后由 BioMan 于 2011-6-7 13:31 编辑 8 l: e" D( {( t9 k
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HoxA9 is a transcription factor that has the potential to expand HSCs, however when overepxressed it has a highly potent leukemogenic activity. HoxA9 deficient mice have a defective in vivo repopulation ability, and impaired in vitro proliferation capacity, but show normal number of HSCs.