癌的进化

sunsong7

The evolution of cancer（癌的进化）
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& r( i+ U- @+ L- ~April 28th, 2011  http://brdygf.info/?p=7898 W% g( @5 O2 F8 ~1 u

9 q- k4 K& @( s正常细胞癌变后标志着癌化过程的结束，但细胞的进化却没有停止。这些细胞根据肿瘤的生物学新特性和新规则有了一个新的起点，并以新的步调继续发展，这就是癌的进化....
, L2 g7 l: a8 Q) V: s* Rnormal cells turn into cancer cells, the marked the end of the process of carcinogenesis. But evolution did not stop, but as a new starting point. According to specific tumor cell biological characteristics and laws of the new, with new wood off the pace to continue to evolve development, It is called evolution, because animal experiments found that the increase in cancer cell populations, while also continue to to acquire new biological properties to continue to increase the degree of malignancy, a qualitative change in the quantitative. Over time. There will be new, differentiated even worse, breeding faster, better adaptation to the environment of the stem cell population, continue to supplement or replace the old, poor adaptability of the stem cell population, which is the constant increase in malignant tumors reasons.
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7 N# M2 ~" F4 i# g5 Y) _the basic characteristics of tumor progression is: Once the evolution began, the general view that has been forward enough, irreversible. Although there are spontaneous regression of cancer, said cancer is still on the whole, the real proportion of rare spontaneous regression. Moreover, the majority of natural healing who have this or that reason. The speed of evolution Polish Museum speed varies, you can slow, but also can compare the abrupt, or accelerating the evolution of rest and support each other to carry the cross . The degree of its malignancy is consistent with the evolution of speed. Evolution faster. The higher the degree of malignancy. Evolution is often endlessly, until the patient died. The evolution of cancer from the initial tumor factors. However, if cancerous, the original cancer-causing factors still exist, and can promote and accelerate the evolution of the role. If the clinical treatment of choice is not appropriate, such as radiotherapy or chemotherapy did not meet the requirements of the dose, incomplete or inappropriate treatment of surgical stimulation. Can facilitate and accelerate their evolution. 0 d& ?; n( ?0 ?4 y

* Z' l8 W8 y4 sthe evolution of the tumor, not simply depend on aspects of the tumor cells, in large part by the body’s complex internal and external factors. In particular, the body’s immune defense systems, feedback regulation factor, more important role. There is a need to further strengthen the mechanism of tumor progression and evolution of knowledge and understanding of the phenomenon. When viewed in the clinical pathology, to see – some special tissue and tumor cells in the phenomenon of students Cancer Treatment materials science characteristics. Have a deeper knowledge and understanding. If the malignant benign, biological behavior and morphological deviations; compound or mixed type tumors, the tumor tolerance to the drug and radiation resistance to the production, etc., can have a deeper understanding of the clinical development of treatment programs and have prognostic significance in patients. : K. o# i7 [3 r  C  |/ w- l; K
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phenomenon of tumor progression in clinical and pathological examination, can often be seen in the growth process of evolving phenomena. Such as the salivary gland pleomorphic adenoma recurrence, can be transformed into low-grade sound, evolving into pleomorphic adenocarcinoma or adenoid cystic carcinoma. The escalation of the degree of malignancy, often repeated recurrence of adenoid cystic carcinoma, malignant degree also will be increased AD. In case of recurrence of verrucous carcinoma, squamous cell carcinoma may be transformed into general, and by the degree of differentiation to poorly differentiated good direction. Sometimes, after radiotherapy, but also to promote its conversion into poorly differentiated squamous cell carcinoma. Although the change has not yet fully understand the mechanism of evolution, but this phenomenon is often seen. Slow-growing or relatively static malignant melanoma can be difficult to find due to certain factors and even sudden to make growth faster, or rapid spread. In the late chronic leukemia can be transformed into acute, which is called the mother cell transformation. The general law of evolution of the cytology of tumor and histological structure of the image is relatively good from the differentiated, evolving into an increasingly poor differentiation. Malignancy is increasing. This performance in the clinical series of biopsy, tumor recurrence, metastasis, and death when an autopsy was to compare it. In biological behavior, often showing more and more vigorous growth activity, infiltrating gradually increase until you get metastasis. Self of the continuous improvement of the degree of malignancy at the same time upgrade. In metabolism, enzyme systems and structural form, more deviation from normal. Radiotherapy, chemotherapy, immunotherapy is also gradually losing sensitivity. & {) X+ Q! i+ j+ H- G' W

; @  A/ I/ ^, w. N' I# R- nfound in animal experiments also showed tumor progression: ascites can be transformative. ascites tumor is a solid tumor of change came. If the solid tumors of serous made of fresh tissue, injected into the abdominal cavity, if caused by ascites tumor cells alone or together into small clusters floating in the active growth of ascites, and ascites can be inoculated to another this animals, which from generation to generation. People will kind of performance is called “ascites can be transformative.” Apart from the above transformative, there are portability, resistance and converted by the hormone-dependent hormone independence. Drug resistance which has a guiding role in clinical treatment. It was found that the tumor cells in vitro after inoculation of the passage of several generations, such as the treatment continues with anti-cancer drugs, you can become drug resistant. Once this resistance remain a long time to produce are often difficult to disappear. And the emergence of drug resistance is a gradual adaptation of tumor cells to drugs and selected results, is also one of the manifestations of tumor progression. This phenomenon is produced by other microbial resistance were similar. In order to avoid drug resistance, in the clinical treatment of malignant tumors should be avoided is not complete, no formal treatment.
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( ^$ \* E: F, [: r7 z, v, J. \oncology cancer medicine treatment of cancer knowledge Source: Sina blog space to move to perfect!
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