Notch和EGFR途径的互作调节神经干细胞的数量和自我更新能力

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, z9 I( P" k/ ]5 K5 ?7 l1 CNotch and EGFR pathway interaction regulates neuralstem cell number and self-renewal
3 A3 v0 C7 L4 t! C: oNotch和EGFR途径的互作调节神经干细胞的数量和自我更新能力
# q3 J# D1 ^' Y0 ]6 S, {# D" \  xAdan Aguirre1{, Maria E. Rubio2 & Vittorio Gallo1
) O- P, u# n7 M5 l' C1Center for Neuroscience Research, Children’s National Medical Center, Washington, District of Columbia 20010, USA. * _# S- U4 m: Y! t. b4 k7 F5 i4 K
Vol467| 16 September 2010| doi:10.1038/nature09347) T( Q  C7 X3 n' P4 G, k" C  ~% R
摘要：Specialized cellular microenvironments, or ‘niches’,modulatestem cell properties, including cell number, self-renewal and fate decisions1,2. In the adult brain, niches that maintain a source of neural stem cells (NSCs) and neural progenitor cells (NPCs) are the subventricularzone (SVZ) of the lateral ventricle and the dentate gyrusof the hippocampus3–5. The size of theNSCpopulationof theSVZatany time is the result of several ongoing processes, including selfrenewal,celldifferentiation, and cell death. Maintaining the balance between NSCs and NPCs in the SVZ niche is critical to supply the brain with specific neural populations, both under normal conditions or after injury. A fundamental question relevant to both normal development and to cell-based repair strategies in the central nervous system is how the balance of different NSC and NPC populations is maintained in the niche. EGFR (epidermal growth factor receptor) and Notch signallingpathways have fundamental roles during development of multicellularorganisms. S) h, n' b; ]4 u( s: p& X
1.特异的细胞微环境调节着干细胞的各种特征，包括：细胞的数量，细胞的自我更新的能力和细胞命运的决定。
7 T9 m( m, C. H+ i2.维持脑室下区中的神经干细胞（NSCs）和神经始祖细胞（NPCs）的平衡对于为脑的发育提供特有的神经元数量起着重要作用。
1 U5 |$ R- w  y+ J1 H. O3.表皮生长因子受体（EGFR）和Notch信号途径在多细胞有机体发育过程中在调节NSCs和NPCs的数量平衡上有重要作用。; W( p) @7 S% j3 ], T