《细胞》[cell]2010年8月20出版pdf全文

scienese

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, c2 I* T, [4 k% F+ \封面介绍On the cover: Cachexia or muscle wasting affects many cancer patients, particularly those with late-stage disease. In this issue, Zhou et al. (pp. 531–543) demonstrate that blocking the ActRIIB signaling pathway with a decoy receptor in several mouse models of cancer boosts muscle mass and prolongs survival even without slowing tumor growth. This treatment reduces the breakdown of muscle proteins by the ubiquitin-proteasome pathway and stimulates proliferation of muscle satellite (stem) cells. The painting on the cover illustrates the dramatic increase in muscle mass and improved quality of life for a tumor-bearing mouse with cachexia after treatment with the decoy receptor. Illustration by David G. Evans; Surfmedia Enterprises, LLC.8 ?8 H) y/ ?% k7 g. n: n! V: F1 q
好可爱的小鼠O(∩_∩)O哈，超喜欢~~
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* F; a' ?# N: k2 p" G  L' FLeading Edge, i; b( @5 @. Y6 r
In This Issue p497
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Cell Culture p501: W5 Z: D0 {" W, O, J. x7 h$ e1 J
Summary | Full Text | PDF (258 kb)7 Y8 \' `, K9 o$ s! B) N, h+ q
Essay
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! j# c( v5 ~5 u7 EInduced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission p507
* Q( `. O3 C: A1 ?: |Ludger Johannes, Satyajit Mayor
" K* }; Z9 o' k. OSummary | Full Text | PDF (450 kb)
( k# F3 M; ^& f; l' |1 a/ dPreviews- K" C0 ~5 q* n/ ?: E  e

7 @3 Y3 i- ]4 g% f- \Reversing Cachexia p511' K1 x8 o8 p5 b3 a4 u
Michael J. Tisdale* c6 T1 C7 B+ F/ H/ x
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The Ins and Outs of EGFR Asymmetry p513
  j. S) i; B) W1 O& r4 q  }Daniel J. Leahy/ g! n5 m$ |3 L
Summary | Full Text | PDF (324 kb)
' }/ r$ |  `" `8 e* F6 xUp a Hydrophobic Creek with a Short Paddle p515
) {6 t! j0 t  YRaymond E. Hulse, Qufei Li, Eduardo Perozo
  J, L+ X4 n& h  L9 fSummary | Full Text | PDF (218 kb)
% {1 V" q, p! s' AThe Immunoproteasome Cleans up after Inflammation p517
9 f5 X& k, J: L" j$ A' ^  d9 B) m+ iSjoerd van Deventer, Jacques Neefjes
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0 |* h; b! K% ~+ _  |Review
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. o. h6 o+ I3 _7 U( G. iFeatured Article, s6 X8 `- |" I, n1 A$ P
Cellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective p519+ U. S+ J, B6 w8 I) t( [$ _" A. s
Daniel A. Koster, Aurélien Crut, Stewart Shuman, Mary-Ann Bjornsti, Nynke H. Dekker, E5 c- _1 Y! p. i# \4 X, G4 V( c# L
Summary | Full Text | PDF (1484 kb) | Supplemental Data, r* m4 S! \& R
Articles
0 n9 k0 d7 t/ i( g) q4 y' wReversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival p531+ M& U) Y3 J/ t
Xiaolan Zhou, Jin Lin Wang, John Lu, Yanping Song, Keith S. Kwak, Qingsheng Jiao, Robert Rosenfeld, Qing Chen, Thomas Boone, W. Scott Simonet, David L. Lacey, Alfred L. Goldberg, H.Q. Han
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+ ]5 T- [% g( |* d2 v  z' a$ q* _PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps p544  W' ~) E( J: A
Jeehae Park, Sua Myong, Anita Niedziela-Majka, Kyung Suk Lee, Jin Yu, Timothy M. Lohman, Taekjip Ha$ y. I0 [, d/ X6 f
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% w+ T) v' X8 B$ f: w5 oThe Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments p556
, A9 p) J  @. m8 |0 g! ]# o  cKevin D. Corbett, Calvin K. Yip, Ly-Sha Ee, Thomas Walz, Angelika Amon, Stephen C. Harrison
; m5 v9 G& q3 x- n4 a8 h* VSummary | Full Text4 o/ }3 X6 x. X/ O. z
Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor p568
$ p" D9 _% p% G2 LDiego Alvarado, Daryl E. Klein, Mark A. Lemmon
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A Shaker K+ Channel with a Miniature Engineered Voltage Sensor p5803 O, F$ o; L) k8 U
Yanping Xu, Yajamana Ramu, Zhe Lu
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, Z' Q# f7 _/ C7 x6 A- R0 \ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death p590
5 g6 U; H1 Y6 k$ ?# m, FLilliana Radoshevich, Lyndsay Murrow, Nan Chen, Estefania Fernandez, Srirupa Roy, Christopher Fung, Jayanta Debnath. o# Q2 t, l* D* g! t! ~8 `
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Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity p601& o2 s, j& }" w; K! S0 a
Tjakko J. van Ham, Mats A. Holmberg, Annemieke T. van der Goot, Eva Teuling, Moises Garcia-Arencibia, Hyun-eui Kim, Deguo Du, Karen L. Thijssen, Marit Wiersma, Rogier Burggraaff, Petra van Bergeijk, Jeroen van Rheenen, G. Jerre van Veluw, Robert M.W. Hofstra, David C. Rubinsztein, Ellen A.A. Nollen
# a0 p& ]( n; v& WSummary | Full Text/ d0 i" E; h+ t6 ]3 E. b
Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress p613
% c7 h1 B; n' b2 k/ BUlrike Seifert, Lukasz P. Bialy, Frédéric Ebstein, Dawadschargal Bech-Otschir, Antje Voigt, Friederike Schröter, Timour Prozorovski, Nicole Lange, Janos Steffen, Melanie Rieger, Ulrike Kuckelkorn, Orhan Aktas, Peter-M. Kloetzel, Elke Krüger: h, A7 d/ z! _7 E$ C, m+ ^* B
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An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis p625
0 P. H8 R1 U+ VMichael J. Moore, Qingqing Wang, Caleb J. Kennedy, Pamela A. Silver
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Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease p6374 b) E9 V# r% r
Daniel C. Gray, Sami Mahrus, James A. Wells
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  E5 b9 e1 v; n, I1 @2 q% ~& a( J! KSnapShot: Homologous Recombination in DNA Double-Strand Break Repair p648.e1
0 c' W* p5 t, `7 q9 h/ ^6 l; L( @Gerard Mazón, Eleni P. Mimitou, Lorraine S. Symington
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