|
- 积分
- 1215
- 威望
- 1215
- 包包
- 7446
|
Liver cirrhosis (LC) is the end stage of chronic liver disease and
) a% H" y9 ]" i% G; s6 ais very difficult to treat. Currently, liver transplantation is one of+ Y1 m4 U5 ^: H8 b5 ^: \ X
the only effective therapies available to such patients. However,) D- @5 \2 H" r% z( |! B( i0 w3 f
serious problems are associated with liver transplantation: lack! ?/ |& i3 ]' Q( Q
of donors, surgical complications, rejection, and high cost. Regenerative6 { _* \# u% U' [; O9 M$ A. L! l
therapies have the potential to provide minimally/ l+ I" r4 l6 z* C* i
invasive procedures with few complications.& E# V8 M$ }: g! T) ~
The potential for stem cells in bone marrow (BM) to differentiate1 y2 r1 q" s; G% u/ n( _
into hepatocytes and intestinal cells was recently confirmed: m4 @* o% i, b3 @. L0 k% R4 P
through detection of Y chromosome-containing cells in
9 L6 i0 {# m/ L% ?9 q) ~4 [samples from female recipients of BM cells (BMCs) from male" O. u" r0 Y q
donors [1–3]. BMC transplantation has been performed to treat6 ]- v: `5 R& v& b
hematological diseases, and several clinical studies have applied9 [ V/ |* I4 M) D
BMC injection to induce regeneration of myocardium and blood
. }2 m' {3 I R& }" ^6 A. g1 C* Fvessels [4]. Taken together, these findings suggest that BMCs& v5 A1 }1 ] q2 x
are effective sources for regenerative liver therapy. |
附件: 你需要登录才可以下载或查看附件。没有帐号？注册
-
总评分: 威望 + 5
包包 + 10
查看全部评分
|
发表于 2010-6-21 19:07
