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本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑
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李凌松*，王 莉
+ E$ b4 q! |" P. b+ `（北京大学干细胞研究中心细胞生物学系，北京 100871）
0 i2 `- f) h2 T2 w摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学/ l6 K: D* w) Z4 h) M& o- r
特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界: j. p4 ~1 T ], R$ L, Y
范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日
3 P. q3 Z5 g7 ~# _起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身
! l+ }& O# p/ p7 [: t, L& |1 t* k涉及的伦理学争论给予概述。/ [$ p5 d2 W- [2 ?) {
关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用
/ @) M: T" y O1 S! |- P5 j中图分类号：Q813 文献标识码：A2 k% G4 J, x- H- R1 ~
Embryonic stem cells
2 a- z9 w# ^/ b! _LI Ling-Song*, WANG Li
' R F( v* F0 A(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)
/ k! f. y5 z9 C S3 JAbstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to
4 f: b8 K1 M- P e- v0 @3 ]) vtheir unique properties, ES cells are used in diverse fields of biological research，particular in developmental, X) f( O% Y) Z5 u& G" J! J
biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation
4 O4 {8 }3 E! R W! y l% Xeggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial.
! ?# E I" B2 ?/ b6 \* y2 eThis review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell
, L. E: K" W/ Z2 uin treating diseases, as well as ethical issues related to human ES cells research.
7 Q' [( L/ w3 |& k: Y5 y; }, YKey words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;
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发表于 2009-2-27 10:29
发表于 2009-7-14 15:44
