PDF电子书：Genes and Common Diseases

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Genes and Common Diseases
3 B8 ]: P/ i; R% d* OGenes and common diseases presents an up-to-date
" K0 A- q) Z, w. p/ [0 oview of the role of genetics in modern medicine,
2 B( w( s) W# Hreflecting the strengths and limitations of a genetic
: e: _6 X0 y! K# A; l) N0 Pperspective.
. ~" Z- Y9 o1 i3 W2 DThe current shift in emphasis from the study of
3 h/ p0 a! o+ H6 Nrare single gene disorders to common diseases
% n3 G; d+ k" L: h  R: ?brings genetics into every aspect of modern
  d6 X  G) Z! h7 c5 q5 mmedicine, from infectious diseases to therapeutics.
" f- Z2 N+ Q" a1 a4 sHowever, it is unclear whether this increasingly4 `8 S' |3 }4 t
genetic focus will prove useful in the face of major5 z  X6 b" D: U7 }/ T  |5 S
environmental influences in many common) P) M$ q9 n9 X7 r. B8 K$ ]
diseases./ D% Z% `" R: b5 q) y! V
The book takes a hard and self-critical look at- `) y. Z3 i) i
what can and cannot be achieved using a genetic
0 v) F& V& G/ Papproach and what is known about genetic and3 F4 |  q$ F; H( B+ U& s
environmental mechanisms in a variety of
% ]" }2 [6 s. J$ m0 g7 D. scommon diseases. It seeks to clarify the goals of# X) @6 E5 I% w7 V
human genetic research by providing state-of-the
/ E* {5 ]' a: r9 Mart insights into known molecular mechanisms' T$ b& k% [! [9 B0 Y& E
underlying common disease processes while at the) E' p& P6 u- b6 j/ U8 a
same time providing a realistic overview of the, O! r7 o; l( P3 |. O
expected genetic and psychological complexity.( U- x- b: B( X5 w8 E
Alan Wright is a Programme Leader at the MRC
" f7 F$ o' i' R6 u* v$ pHuman Genetics Unit in Edinburgh.
8 ^" O$ o% G+ B& K  ^( B& @, pNicholas Hastie is Director of the MRC Human
% H1 V+ y: h2 q( t: c2 B. ZGenetics Unit in Edinburgh.( R) J, k( e9 ]+ k
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