日本自然科学研究机构基础生物学研究所科学家发现精子能“返老还童”（附原文）

细胞海洋

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新华网北京４月４日电（记者钱铮）日本科学家日前报告说，在精子形成过程中，部分细胞能“返老还童”，向干细胞逆转。
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) r2 \& o" M; f$ s5 V8 c; ^( G　　日本自然科学研究机构基础生物学研究所发表新闻公报说，该所教授吉田松生和京都大学研究员中川俊德等合作发现，精子形成过程中的细胞在一定时期内可以“返老还童”，变回干细胞。; A$ J3 U( W0 B6 Y
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　　上个世纪七十年代，科学家提出精子形成的“Ａｓ模型”。根据这个模型，精子的形成过程是这样的：干细胞分裂产生两个细胞质相连的子细胞。随着分裂继续，子细胞数量逐步增加到４个、８个、１６个……$ _. D, I  o5 m4 _+ {+ O/ P+ N: }

. R0 y! R  [4 w' g* K+ y9 z: n　　以前认为，这种分裂过程是不可逆的，即分裂后的细胞无法再回到干细胞状态。吉田松生等的成果修正了这个错误认识。/ x! C+ p, `0 `

0 F8 [  E& Z! N' D  D　　在研究中，科学家利用绿色荧光蛋白跟踪精子的形成过程。结果发现，大部分细胞形成精子的同时，还有一小部分细胞回到初始的干细胞状态。; ~+ H- B! J8 [6 S
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　　日本科学家的论文发表在美国《科学》杂志网络版上。
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* \3 B1 ~4 h! d6楼原文 感谢dxb1985 提供

冰罗布

学习了

dxb1985

文章名称怎么查不到啊

dxb1985

终于找到了。Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment

lizukun

很有意思

Hongwu

Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment' w& x( @$ H5 S+ ]8 Z& \
Toshinori Nakagawa,1,* Manju Sharma,2 Yo-ichi Nabeshima,1 Robert E. Braun,2 Shosei Yoshida1,3,4,
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Stem cells support tissue maintenance by balancing self-renewal and differentiation. In mice, it is believed that a homogeneous stem cell population of single spermatogonia supports spermatogenesis, and that differentiation, which is accompanied by the formation of connected cells (cysts) of increasing length, is linear and nonreversible. We evaluated this model with the use of lineage analysis and live imaging, and found that this putative stem cell population is not homogeneous. Instead, the stem cell pool that supports steady-state spermatogenesis is contained within a subpopulation of single spermatogonia. We also found that cysts are not committed to differentiation and appear to recover stem cell potential by fragmentation, and that the fate of individual spermatogonial populations was markedly altered during regeneration after damage. Thus, there are multiple and reversible paths from stem cells to differentiation, and these may also occur in other systems.
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男性不育患者看到了希望！

dxb1985

回复 6# Hongwu

longman89

弱弱地问一下：
- X# y) v7 B" F( g) @4 u日本的那些科学家是如何观测到这一现象的？
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( I/ _% T9 ^9 w# ^0 H' {# c& Y疑惑中，下原文拜读。

piggyfield

O(∩_∩)O哈哈哈~理解~蛋白N元素标记跟踪法~

dxb1985

回复 9# piggyfield 7 ~+ _7 Z/ I. C7 ^0 U( ]) q
请问你那里有蛋白N元素标记跟踪法的英文文献吗，我想了解一下，谢谢!