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(Milestones timeline for cancer research)4 y6 K0 N. m; v9 P0 s
" P1 q+ o5 e( S7 r2 E: l- F: y
1889 seed and soil hypothesis / }* I8 h# s9 R! J
种子与土壤假说
! \0 y2 f; M2 L3 L1890 cancer as a genetic disease
1 y% @3 h$ u& s3 H) O1 q, ?2 x 肿瘤是一种遗传性疾病
0 x2 Z0 b1 y7 ^ O& t1909 immune surveillance, u8 a- C* i. c0 w& V
免疫监视
/ V7 b; u- a* \ |1910 viruses and cancer
7 Y9 W0 s. V/ p" P8 m" V/ `- ] 病毒与肿瘤. }! ~: X0 n7 K, W. r* Z
1915 hormones and cancer
8 ]4 q- n2 L, m! r 激素与肿瘤$ I7 Z% g4 _: A
1937 cancer stem cells$ l$ a2 T6 r4 W
肿瘤干细胞
6 c1 i5 I9 k7 o% Q6 H0 Y6 k1939 angiogenesis
! F/ G7 r" k8 V; h 血管发生: l' }4 @/ E* n: {* X/ b
1950 smoking and cancer ! ^( }7 U8 i+ z0 U& j
吸烟和肿瘤% k( j- n: N ]) \* [) c6 L
1953 two-hit hypothesis" R: ]$ Q o h! b
二次打击学说/ f" r* K; q& Y
1960 chromosome translocations ; h8 P0 j. y$ x- w; }$ t% ?$ }
染色体易位8 t ~6 z* P( I# L* `
1971 tumor suppressor genes
v2 S2 ]7 q. K% y" q! i/ Z 肿瘤抑制基因. g9 e, w1 l- b. ` r: W' c
1972 apoptosis and cancer
+ r$ i0 `2 ^7 Y9 ]: n1 X+ Y# v 凋亡与肿瘤
8 O6 G; S5 e5 E1 e( n8 h3 d. O1975 tumor microenvironment N6 a( ]0 i8 c, v# R: J. D4 ]% J
肿瘤微环境
! Z) Y: t5 ]4 V3 r1976 clonal evolution and mutilstep tumourigenesis 0 Z2 v, }/ s* O, Z( _1 X! t9 H
克隆演变与多步骤肿瘤发生 q F4 _6 L+ ~% k3 u
cellular homologues of viral oncogenes
o; T' v+ i; G, R& P& j! ^ 病毒癌基因的细胞同系物
7 ]/ p! m. H. _* u& p0 f. W1978 oncogenes encode proteins that regulate cell growth
9 F" O% z1 i8 C- ?0 k% x# z* F 癌基因编码蛋白调控细胞生长
( Q$ b- W+ v' |# }1979 first human oncogene+ f) R; _- a1 S
第一个人类癌基因% W1 u" l3 J! `8 z) u/ ], d
1983 oncogene co-operation . I( L' t1 R& h' v' k q
癌基因的互相合作
Z- L, v9 Q7 I0 b; u cancer epigenetics
+ D+ e. b: N* q, S0 u0 H! d# T0 y- o 肿瘤表观遗传学4 ^5 n3 W) Y f5 B8 t- q/ Y
1989 cell cycle and DNA damage checkpoints
I L0 j! S2 h% M1 I1 t 细胞周期和DNA损伤检查点
& Y( h5 E! m' K! @1990 genetic basis for cancer predisposition- P& H& A6 N& Q* b+ X
肿瘤易感性的遗传基础
9 I5 n) v: x$ t0 x7 e* d! g" Z mechanism of genetic instablitily in cancer
! Y3 F$ `& V7 H% L 肿瘤遗传不稳定性的机制" ~. y9 Q- Q7 a+ T3 q+ a
1999 cancer profiling
4 V3 S3 a/ A0 t# r 肿瘤谱
9 k6 g5 d. I$ D) p8 W2001 targeted cancer therapy
- L7 o: T0 [" B! I 肿瘤靶向治疗 |
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