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Generation of Induced Pluripotent Stem Cells using Recombinant Proteins( f; M5 |1 |" O' ]0 D; w6 W+ }) D
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4 L7 _, c9 }# U: a2 [+ D2 Tall of the methods developed todate still involve the useof geneticmaterials and thus the potential for unexpected genetic modifications by the exogenous sequences in the target cells. Here we report generation of protein-induced pluripotent stem cells (piPSCs) from murine embryonic fibroblasts using recombinant cell-penetrating reprogramming proteins. We demonstrated that such piPSCs can long-term self-renew and are pluripotent in vitro and in vivo. |
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