|
- 积分
- 17983
- 威望
- 17983
- 包包
- 26159
|
 " w, ?$ v8 C; i! I( C$ @: G
Volume 38, Issue 5' h7 U: [4 ]) o; t9 E* q3 C3 O2 K' w
On the cover: Regulation of metabolic pathways in the immune system provides
7 X9 f3 {$ c4 |3 W2 Da mechanism to actively control cellular function, growth, proliferation, and
4 {: c" A7 a$ x. n0 Isurvival. However, the contribution of microRNAs to the regulation of cellular / W' H- H# g' `
metabolism in the immune system is unclear. In this issue of Immunity,
s, ^/ L5 X+ `& YHenao-Mejia et al. (984–997) show that the miR-181 family is a critical
- D6 h( x1 M: h: `determinant of cellular metabolism, and therefore it is essential to support the : J- |1 k p9 f: P. @
high biosynthetic demands of lymphocyte development. In particular, regulation
. |+ {! L$ n5 ?" fof cellular metabolic pathways by miR-181 is absolutely required for early ( K9 ~2 i. N/ l# O/ p9 ^$ X
natural killer T cell development. The cover cartoon depicts a lymphocyte that
" h5 `9 O5 Z, C/ F( Y' Knecessitates the presence of miR-181 (represented as an electrical plug) to , Q4 A+ s+ e# N$ z& x7 U3 [
maintain a robust metabolism. Thus, in the absence of miR-181 (unplugged : N" g# D/ s! a; | Z; t; ?/ B7 K. g/ K
status), the lymphocyte lacks the energy to efficiently carry out normal 4 a! e# H' \+ J% S
functions. Image created by Gustavo Zapata.3 r( o: \# u+ ~0 u6 |3 _
|
-
总评分: 威望 + 20
包包 + 20
查看全部评分
|
发表于 2013-5-24 20:52
