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Volume 38, Issue 5+ D7 d7 {8 u: R$ ?7 |1 w1 h
On the cover: Regulation of metabolic pathways in the immune system provides ) Y6 w/ I X) b/ j9 a8 C: U" Z
a mechanism to actively control cellular function, growth, proliferation, and
: }8 ]8 e. s2 ~- S" h% h Qsurvival. However, the contribution of microRNAs to the regulation of cellular
0 \6 H4 O1 k- |, }: } ^metabolism in the immune system is unclear. In this issue of Immunity, 2 j* c6 I" b3 k
Henao-Mejia et al. (984–997) show that the miR-181 family is a critical 6 ]: P' X, R$ X+ Z9 P
determinant of cellular metabolism, and therefore it is essential to support the + Y( L) L% B# j- _2 Y) n. r
high biosynthetic demands of lymphocyte development. In particular, regulation # V$ B; Z) o3 p2 g4 z
of cellular metabolic pathways by miR-181 is absolutely required for early
. t( e9 x2 y& w- [! \natural killer T cell development. The cover cartoon depicts a lymphocyte that 2 b1 c: ~; d! E9 P9 F! `. ]
necessitates the presence of miR-181 (represented as an electrical plug) to
6 ^9 s5 Q* `' S) _& E% mmaintain a robust metabolism. Thus, in the absence of miR-181 (unplugged
: a! L/ h3 f! e1 kstatus), the lymphocyte lacks the energy to efficiently carry out normal
; j* w" I1 Y y: F3 T' [functions. Image created by Gustavo Zapata.
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发表于 2013-5-24 20:52
发表于 2013-5-24 21:18
