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In additional mating studies we have conducted (as yet unpublished)
% @8 \1 K1 ~7 Qusing wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous
9 R# Y8 A3 F) c: A! g+ d% n# Wbreeding assay following heat shock. Results from these
$ k6 s9 R1 Z" e1 r) W8 r) S* A% f& Xexperiments separate the histopathologic lesions in early5 G8 q g* a3 {" V) f6 q6 o. ^
and late spermatogenic stages (i.e., apoptotic spermatocytes),( B. D* A# I6 c k" _% w4 @
which are dependent on HSF1 and inducible HSP* a6 B/ G+ ~9 l
expression, from longer-term effects on reproductive performance
$ w9 W9 s( I* c- grelating to spermatocyte-specific but stage-independent
0 q2 ~) W8 r5 B9 [" V b \effects.
# p% j1 {; f0 q7 G; \' }# F来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,
. e0 E0 H) N' @' a- |# S4 Z* h, \- sand Fertility in Adult Male Mice。8 G) p: e' Z9 z/ w* ~
236页删划线部分
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