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本帖最后由 细胞海洋 于 2013-4-23 11:11 编辑 ; c" Q+ j0 T, e" J
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Volume 38, Issue 4
' Z( R/ } D; {% P! ^On the cover: The lymphoid stromal microenvironment is required to provide 3 Y8 d: m5 P/ }( n1 s
structural support for lymphocyte migration, localization, and function. By fate / D0 c; Z c! }' p3 ^
mapping analysis, Castagnaro et al. (pages 782–791) show that mature stromal 4 ?. u# A. o+ s7 x; j0 W* q2 B
cells originate from embryonic mesenchymal progenitors of the + A# V7 k( G: W- z6 p `7 M
Nkx2-5+Islet1+ lineage. This study suggests the presence
8 J- Q, ^" T0 ~- D8 [# @of multipotent progenitors that generate distinct stromal cell subsets and
3 H0 ^$ ]( Y1 ^participate in lymphoid tissue remodeling and repair. The cover image depicts a
. H' k& }3 k% b% K9 J% Shierarchical model for generating the stromal microenvironment in development B1 Q+ u5 K. c4 ?6 v r2 e
and organ regeneration whereby the roots represent the stromal progenitors
3 m2 B8 T1 [7 y) kgiving rise to fibroblastic reticular cells, follicular dendritic cells, and 0 [: `/ M% Y) ?$ f. F7 Y
marginal reticular cells as represented by the leaves. Image by Laura Castagnaro
. Q1 a# I) p H& ^, w4 Mand Samir Khadem.
; R2 F5 D& ]2 g' l. ]: C4 Q/ |2 b
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发表于 2013-4-22 20:01
