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In additional mating studies we have conducted (as yet unpublished)
8 G- T/ @; J3 C, \using wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous: B2 l( S- j* d
breeding assay following heat shock. Results from these
7 z/ P1 q* `8 _. Qexperiments separate the histopathologic lesions in early9 ]/ ?: k! x. _6 L% m7 m- B8 i* _
and late spermatogenic stages (i.e., apoptotic spermatocytes),
8 |+ K m* }' D% {6 g/ W, lwhich are dependent on HSF1 and inducible HSP
* O% F# H# V4 y- w3 A' v7 C, jexpression, from longer-term effects on reproductive performance
5 P" {3 e) }% Y. `% L+ t5 j( _, crelating to spermatocyte-specific but stage-independent
_2 @; j/ p* h. v5 Q! w1 feffects.0 Y/ ]$ l- T8 ]% h
来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,
: R6 `9 U5 u0 w1 i8 |6 z6 \! \and Fertility in Adult Male Mice。" `4 j6 o' ^4 J4 k4 x0 K, w3 b( n
236页删划线部分6 N G$ F9 c ` `0 q% E6 f
6 q. A( Z% w2 O3 l* t- K9 f谢谢哦。 |
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