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Non-Viral Gene Therapy
: M/ |4 e$ }* {$ U& F% ?Edited by: Xu-bo Yuan
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ISBN 978-953-307-538-9, Hard cover, 696 pages
. g% ]$ l% m/ ]/ a' D: ?Publisher: InTech' A5 g; I8 f' o5 H! l$ T& ]
Publication date: November 2011
% n, ?4 L! d0 J+ X0 v5 lSubject: Gene Therapy
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) F6 g( K/ K* h2 w" [This book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation.
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Table of Contents8 d9 u( G: C3 ~. M+ v+ L
Non-Viral Gene Therapy Vectors Carrying Genomic Constructs! A$ v$ P; D% h8 Q( a
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Non-Viral Delivery Systems in Gene Therapy and Vaccine Development
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+ c. L2 o8 _ D( m" V' S2 W" DGene Delivery Systems: Tailoring Vectors to Reach Specific Tissues: a7 h5 D; y3 C" Y; D s7 U+ V
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Investigation of Transfection Barriers Involved in Non-Viral Nanoparticulate Gene Delivery in Different Cell Lines
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4 K8 D* @/ E. A' C9 G/ e4 u4 _The Mechanical Agitation Method of Gene Transfer for Ex-Vivo Gene Therapy
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Gene Therapy of Some Genetic Diseases by Transferring Normal Human Genomic DNA into Somatic Cells and Stem Cells from Patients, y' u7 W6 o$ U0 n$ c% s
' q" b/ t/ ]% @, k2 q5 K( }5 qNon Viral Gene Transfer Approaches for Lysosomal Storage Disorders
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. F$ o6 i% Q+ L( z. [: ADNA Vaccination by Electrogene Transfer0 f& J5 L4 N: ^. U: {" A8 B: S
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Gene Delivery with Ultrasound and Microbubbles
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Ultrasound-Mediated Gene Delivery
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Polyamine – Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity5 k3 d" C" |9 j* b3 h
7 w# W0 }2 ?( [0 QTechnological Aspects of Scalable Processes for the Production of Functional Liposomes for Gene Therapy
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Cationic Liposomes in Different Structural Levels for Gene Delivery1 G0 v) T+ g! _4 Q0 W% `
# _- ~/ q. b; A" @/ o1 h. zNeutral Liposomes and DNA Transfection. n- U7 j- V- F A: |6 Y
! p0 z8 n8 T2 G- ONon-Viral Gene Delivery Systems Based on Cholesterol Cationic Lipids: Structure-Activity Relationships
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0 Y2 [ s; k( }Polycation-Mediated Gene Delivery: The Physicochemical Aspects Governing the Process
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Medical Polymer-Based Gene Therapy
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: `( E8 Q% b" @, `- b# Y9 M9 Y* ?Chitosan and Its Modifications: Are They Possible Vehicles for Gene Therapy? `( t1 n! G& c
5 o( x( u* |3 I& ]$ y9 r# ~+ }Chitosan-DNA/siRNA Nanoparticles for Gene Therapy8 V0 b2 s4 B$ W' h) X8 U
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Toxicity of Polymeric-Based Non-Viral Vector Systems for Pulmonary siRNA Application
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PAMAM Dendrimer as Potential Delivery System for Combined Chemotherapeutic and MicroRNA-21 Gene Therapy% @1 ?7 j/ ?' g. C
( C8 U2 {) e8 ^9 c9 eNanomedicine Based Approaches to Cancer Diagonsis and Therapy9 A6 X3 L b' [4 ?
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Toxicogenomics of Nonviral Cationic Gene Delivery Nanosystems- N. {- r% @, r' G9 D
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Nano-Particulate Calcium Phosphate as a Gene Delivery System2 i- h8 f% ]) a3 ^$ D' M
' B/ z7 M( Z4 j& ^2 J5 N! f1 ~" GModular Multifunctional Protein Vectors for Gene Therapy) J7 |$ x9 y) l5 w0 r
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Peptides as Promising Non-Viral Vectors for Gene Therapy7 U" `: i- s$ }& V
7 I4 K6 e5 ^: i' ?3 nBinding of Protein-Functionalized Entities onto Synthetic Vesicles- s0 {0 d7 c* ?6 \* ` X
4 c; c0 o0 N" X3 d# ~Targeting TRAIL Receptors with Genetically- Engineered CD34+ Hematopoietic Stem Cells
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Pyrrole-Imidazole Polyamides for Gene Therapy: Bioanalytical Methods and Pharmacokinetics$ n8 z7 c( Q: A% E1 H& h) B# s4 B
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