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In additional mating studies we have conducted (as yet unpublished)
, X5 B7 _: C2 k) u$ k/ |% busing wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous0 S+ |) j! K k' i; J0 Z
breeding assay following heat shock. Results from these" b8 U: t6 F a4 j$ H/ S
experiments separate the histopathologic lesions in early
. S" w* J8 t; Wand late spermatogenic stages (i.e., apoptotic spermatocytes),: Z M# k. b4 z8 p5 ~# d
which are dependent on HSF1 and inducible HSP4 M+ D* B. o/ s$ T
expression, from longer-term effects on reproductive performance$ a/ d. l, n* l( l7 s
relating to spermatocyte-specific but stage-independent$ p) T5 h0 c3 }6 O) [; y
effects.
/ {4 ^9 h M8 b7 }来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,$ T/ ?% E7 B7 ~
and Fertility in Adult Male Mice。
, Q, [) j' f; o' D4 v( F0 a! K. y236页删划线部分. ^" p, _0 P% J" `# C
. l% e, K9 V6 S% z8 d
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