PDF电子书：Embryonic Stem Cells – Differentiation and Pluripotent Alternatives

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5 b8 K- }: V1 Q, E' E# {+ ?6 E* vEmbryonic Stem Cells – Differentiation and Pluripotent Alternatives
$ h; |* N( K. lEdited by Michael S. Kallos, F. b' }- z2 N. A/ u0 e0 A5 z
Published by InTech
4 v% N2 A" @  x8 D- \Janeza Trdine 9, 51000 Rijeka, Croatia- @1 @# I, c. R( j
Copyright © 2011 InTech
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Contents) X9 o5 i# K, m/ _/ ]3 h
Preface IX, q8 [7 P) |! Z: d& P
Part 1 General Differentiation 11 _! `+ f+ Y, y3 S" x# h. |1 ?
Chapter 1 Role of Signaling Pathways and Epigenetic& T& o+ w4 u2 S  ]  O& O% c+ q
Factors in Lineage Determination During0 r) u2 F5 R% ~  _+ o4 X
Human Embryonic Stem Cell Differentiation 3( O) A& R0 t. z( w
Prasenjit Sarkar and Balaji M. Rao" a, S! d! r8 o7 {, B+ e4 R+ M3 d
Chapter 2 Bioactive Lipids in Stem Cell Differentiation 33
9 b8 Y, u+ c2 HErhard Bieberich and Guanghu Wang
# g* V1 }. ]1 s0 U1 [1 YChapter 3 Retinoid Signaling is a Context-Dependent
# S) v+ d" q0 B6 E( bRegulator of Embryonic Stem Cells 554 I- O: p- K3 T
Zoltan Simandi and Laszlo Nagy
! v; k  J$ ~8 Q) `Part 2 Neural and Retinal Differentiation 79
. y) M& B) V% h1 [: Y6 bChapter 4 Pluripotent Stem Cells as an In Vitro5 Q2 @1 y& q4 P
Model of Neuronal Differentiation 81
4 p2 I- ~7 s6 i% o+ [4 O& A# LIrina Kerkis, Mirian A. F. Hayashi,) A/ ~8 q) g* u* ?* e
Nelson F. Lizier, Antonio C. Cassola,
+ r% S  \# j. D- W+ @Lygia V. Pereira and Alexandre Kerkis
* {* c8 P9 S  f+ [# YChapter 5 Characterization of Embryonic Stem (ES)
* c. ~: Q- j/ S; K+ K' tNeuronal Differentiation Combining Atomic Force,
; Z& e( x( Y4 W' p" YConfocal and DIC Microscopy Imaging 99
3 I  L; Z6 F/ fMaria Elisabetta Ruaro, Jelena Ban and Vincent Torre/ |6 o* [& m5 J* S$ h
Chapter 6 Oligodendrocyte Fate Determination, F9 s9 ?4 r7 a1 Y9 Y
in Human Embryonic Stem Cells 119
- }  b- }# r$ FSiddharth Gupta, Angelo All and Candace Kerr
4 u$ u, w, T8 F3 sChapter 7 Stem-Cell Therapy for Retinal Diseases 135' v) G. I9 t4 f0 G0 x( [
Rubens Camargo Siqueira+ h7 B. x5 O/ K: M  Y5 a' T
VI Contents
% F" b/ C3 G6 @  t% t3 Y: MPart 3 Cardiac and Other Myogenic Differentiation 149" r4 ~7 t$ i, a& O  P; a$ ~4 G
Chapter 8 Transcriptional Networks
: |/ Z  k. R" F1 L+ c  {: cof Embryonic Stem Cell-Derived Cardiomyogenesis 151
" c$ C& C! P  _& T" `5 q/ \9 f7 fDiego Franco, Estefania Lozano-Velasco and Amelia Aránega. ~- `: _3 C3 P/ m! J5 S
Chapter 9 Human Pluripotent Stem Cells
& r( Z" z" l8 l# L. a$ W7 Ain Cardiovascular Research and Regenerative Medicine 169  l9 d# Q$ N& D1 O
Ellen Poon, Chi-wing Kong and Ronald A. Li
5 q8 Z1 B' i+ ]+ a6 XChapter 10 Human Pluripotent Stem Cell-Derived Cardiomyocytes:$ s9 `% Q3 Y* b; b
Maturity and Electrophysiology 185
6 ]8 Z( v# T" j& l: w) G5 |Ville Kujala, Mari Pekkanen-Mattila and Katriina Aalto-Setälä0 J* n* h- K, r/ Z9 m
Chapter 11 Maintenance Of Calcium Homeostasis3 Y; C+ Y# q3 E5 j( K. x+ n
in Embryonic Stem Cell-Derived Cardiomyocytes 2058 H( [7 f% A  g8 ]" n
Iek Chi Lo, Chun Kit Wong and Suk Ying Tsang' ~3 X' R6 d+ Q3 X3 P& f
Chapter 12 Myogenic Differentiation of ES Cells for Therapies3 T/ i, K/ v9 X' {5 f8 y" |0 o4 c
in Neuromuscular Diseases: Progress to Date 227
, u) e- q) L$ q' b$ N2 E3 N% @Camila F. Almeida, Danielle Ayub-Guerrieri and Mariz Vainzof. A  K$ Z! K* b( {
Part 4 Endothelial Differentiation 243
/ ]5 j" U! O! }0 V, }# gChapter 13 Dissecting the Signal Transduction Pathway
: A4 w4 p% c; F- |1 mthat Directs Endothelial Differentiation Using
* t2 ^0 c7 ], t0 K& xEmbryonic Stem CellDerived Vascular Progenitor Cells 245
1 S: H" v) F% C% N' a: C6 oKyoko Kawasaki and Keiji Miyazawa: o! m3 V9 D, k  X" I
Chapter 14 Endothelial Differentiation of Embryonic Stem Cells 267
5 ?1 A* Q6 ?4 L3 f+ f7 s8 JPeter Oettgen; D& B$ q0 W) _% ]% ^
Part 5 Hepatic Differentiation 2778 R' ]/ v8 i2 L+ v. V! d
Chapter 15 Stem Cells for HUMAN Hepatic Tissue Engineering 279
# v7 S' K( ^% Z8 D" v3 B( ]N.I. Nativ, M.A. Ghodbane, T.J. Maguire,, }; Y$ J# X0 W( m1 o
F. Berthiaume and M.L. Yarmush
5 [' N$ l/ v) \. L0 r& UChapter 16 Hepatic Differentiation of Human Embryonic and Induced
" |' Y" @- l$ z" r& M) {; uPluripotent Stem Cells for Regenerative Medicine 303
; s0 p( B2 g: \; [Toshio Miki6 v# F1 K: l. M8 Q# B
Part 6 Osteogenic Differentiation 321, |! q. G  F5 L- H% l+ N1 H/ t! d
Chapter 17 Osteogenesis from Pluripotent Stem Cells:  H4 @: p( ~8 ^6 e, Q7 _, y2 G2 \, @& R
Neural Crest or Mesodermal Origin? 323
8 Y4 D7 n; j5 O$ R  j" pKevin C. Keller and Nicole I. zur Nieden% e0 U( C- k/ o, g$ D* W; s1 }+ @' B) G
Contents VII
7 K, s5 _$ }% J% e& M$ yPart 7 Pluripotent Alternatives –
3 q3 g% d& ]. i0 `8 g& A7 n8 ?# VInduced Pluripotent Stem Cells (iPSCs) 349  q! U4 ~2 M1 p9 `, q& T# P
Chapter 18 The Past, Present and Future of; J1 z* O4 I8 O
Induced Pluripotent Stem Cells 3510 f9 U# \- \& P( w3 S7 c: u$ p
Koji Tanabe and Kazutoshi Takahashi
$ s" z# O% g( {: F3 H, z/ jChapter 19 New Techniques in the Generation( R  J9 L, ]3 L# l
of Induced Pluripotent Stem Cells 373
8 K5 x( b& Y% q% d; XRaymond C.B. Wong, Ellen L. Smith and Peter J. Donovan
) ?9 M6 B6 A6 G9 b6 L* ?5 Y: OChapter 20 Generation of ICM-Type Human iPS Cells* `% b' l8 m  D% U# {* ^% G' Y
from CD34+ Cord Blood Cells 399
: d# V5 I0 \, {( a- [Naoki Nishishita, Noemi Fusaki and Shin Kawamata
! K* U- b9 t6 q+ m' X: \  L# Z4 W- JChapter 21 Modelling of Neurological Diseases
; _5 s% Z# _; A. w; h; XUsing Induced Pluripotent Stem Cells 413
* v% v8 c( a2 d0 `2 v5 U% P; h/ Z6 p/ IOz Pomp, Chen Sok Lam, Hui Theng Gan,  d6 A  p; `5 }; k3 i) B3 R- U& r
Srinivas Ramasamy and Sohail Ahmed0 ]0 ~* z7 l3 ^1 A  e& D" G
Part 8 Pluripotent Alternatives - Other Cell Sources 431' S- s+ V5 h( u( l  [4 n+ l; V6 m. v4 E
Chapter 22 Very Small Embryonic/Epiblast-Like Stem Cells (VSELs)5 F# F( W3 p; `% p
Residing in Adult Tissues and Their Role* `' M% n- ^  V, a( X' S# b
in Tissue Rejuvenation and Regeneration 433, k/ \) c; H. ?4 i  W3 ^
Dong-Myung Shin, Janina Ratajczak,
/ X" E3 w0 @- @Magda Kucia and Mariusz Z. Ratajczak9 i% ~/ W/ l/ T. b
Chapter 23 Multipotent Dental Stem Cells:
9 ]1 D4 l7 R) FAn Alternative Adult Derived Stem$ U' C& X# S2 g! Q
Cell Source for Regenerative Medicine 4513 @. @! g4 D6 b6 M/ Z0 R9 h  h# G
Tammy Laberge and Herman S. Cheung/ |: K6 _1 @7 E6 C- f) H* c
Chapter 24 Pluripotent Stem Cells from Testis 473
% T+ e8 k9 |# _) y, @Sandeep Goel and Hiroshi Imai
( P0 d! l/ r- F& `, x: i  nChapter 25 Amniotic Fluid Stem Cells 4937 e+ E+ {/ N2 w) M/ N
Gianni Carraro, Orquidea H. Garcia," i6 ?( r# y% b$ V3 E
Laura Perin, Roger De Filippo and David Warburton
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