PDF电子书：Embryonic Stem Cells – Differentiation and Pluripotent Alternatives

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Embryonic Stem Cells – Differentiation and Pluripotent Alternatives
( {1 N# ]2 ^' R$ H5 X# Q* y/ m% qEdited by Michael S. Kallos/ T( s6 G9 N* n: X* G
Published by InTech
0 k+ f) M0 D# ~. C& IJaneza Trdine 9, 51000 Rijeka, Croatia
& v- S* s4 z7 O& O! m: n3 sCopyright © 2011 InTech
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Contents# n2 y5 U( u- ]; d
Preface IX
  m% x0 N% e+ J5 F9 N- RPart 1 General Differentiation 16 [7 v  e# \7 j: p
Chapter 1 Role of Signaling Pathways and Epigenetic1 ?$ y2 g4 ?& J- X
Factors in Lineage Determination During
. x+ x3 f6 I( y$ }* k1 |3 x+ pHuman Embryonic Stem Cell Differentiation 33 ?( c( k  R8 g3 m' E
Prasenjit Sarkar and Balaji M. Rao
. j' v% ~1 ^/ d. [' j/ dChapter 2 Bioactive Lipids in Stem Cell Differentiation 33
. y4 ^7 [: }' ~8 V) s2 N& vErhard Bieberich and Guanghu Wang" C# U3 R, M. T' Y
Chapter 3 Retinoid Signaling is a Context-Dependent: R3 O2 z& B& [; x4 P
Regulator of Embryonic Stem Cells 55
9 t/ L' F7 z" R9 e$ p6 oZoltan Simandi and Laszlo Nagy5 |  p. c, r) E- Q' @4 ?& X
Part 2 Neural and Retinal Differentiation 79, X3 l* \1 O: ?  o5 Z) C" ]9 t% a
Chapter 4 Pluripotent Stem Cells as an In Vitro8 B: H" h- I1 R7 `" F" r, X
Model of Neuronal Differentiation 81: u% x* x$ U/ U9 g9 o
Irina Kerkis, Mirian A. F. Hayashi,
- m# z4 N3 l5 U6 |Nelson F. Lizier, Antonio C. Cassola,) E! e9 W' i0 N
Lygia V. Pereira and Alexandre Kerkis
% P8 D4 K! T! i* l* QChapter 5 Characterization of Embryonic Stem (ES)
- H7 J' p! C4 ]) PNeuronal Differentiation Combining Atomic Force,
! Z; m, d5 ]& n$ e6 rConfocal and DIC Microscopy Imaging 99
  J4 u' ~' x! D9 R9 ^% p: P) \0 uMaria Elisabetta Ruaro, Jelena Ban and Vincent Torre
+ P) {2 _5 K/ |6 l  D9 b* ?5 wChapter 6 Oligodendrocyte Fate Determination
9 n; [; L7 a4 X5 j. lin Human Embryonic Stem Cells 1192 f4 H9 \1 ?/ c) @  s+ ~! o: Z; u
Siddharth Gupta, Angelo All and Candace Kerr
2 y. u- M& x/ ]6 V" ]" KChapter 7 Stem-Cell Therapy for Retinal Diseases 135
. x5 }0 Q# t; TRubens Camargo Siqueira5 Z( x2 F* ~5 ~5 b
VI Contents
: I+ y! F+ O) TPart 3 Cardiac and Other Myogenic Differentiation 149% d# {0 V+ H5 Z8 F9 K. M
Chapter 8 Transcriptional Networks
, c. D" R6 a, P( z5 b; j+ Y3 fof Embryonic Stem Cell-Derived Cardiomyogenesis 1510 u# f: Y) x4 l! v0 m
Diego Franco, Estefania Lozano-Velasco and Amelia Aránega  V; I9 ?& S: X( w  `
Chapter 9 Human Pluripotent Stem Cells" ~8 ?( B: b/ ^# B: l# M& ^3 j
in Cardiovascular Research and Regenerative Medicine 169
& x* ~! s2 p! d: h* r) P9 E; N6 zEllen Poon, Chi-wing Kong and Ronald A. Li4 f& V4 t2 I3 |% G' V+ P
Chapter 10 Human Pluripotent Stem Cell-Derived Cardiomyocytes:6 {" R- u. L) H) d8 H4 O' j, q$ M+ w
Maturity and Electrophysiology 185& P; E+ D6 M2 h5 |% V) }% [$ U
Ville Kujala, Mari Pekkanen-Mattila and Katriina Aalto-Setälä
0 j5 d* ~, v# K! SChapter 11 Maintenance Of Calcium Homeostasis
; K' I( c( q' ]6 ~* o8 }( A3 b4 sin Embryonic Stem Cell-Derived Cardiomyocytes 205, ~! Q% ^) O" \. r
Iek Chi Lo, Chun Kit Wong and Suk Ying Tsang. c/ Y9 S1 ?% |
Chapter 12 Myogenic Differentiation of ES Cells for Therapies
9 j* v' P' p4 `' J* c% e2 m0 S, uin Neuromuscular Diseases: Progress to Date 227* q0 u' ]' [$ x" A7 K
Camila F. Almeida, Danielle Ayub-Guerrieri and Mariz Vainzof  Y# `1 o+ r6 r" M2 J
Part 4 Endothelial Differentiation 243$ R* k7 Z6 P  e
Chapter 13 Dissecting the Signal Transduction Pathway
* j% R- |$ M* P9 Y) F. Y. v: c! ithat Directs Endothelial Differentiation Using
# K" f, D- `. R% I$ m0 SEmbryonic Stem CellDerived Vascular Progenitor Cells 245
: _. ^2 h( g* P% x  O9 I- ~; iKyoko Kawasaki and Keiji Miyazawa
) k2 E9 C+ y' j0 R4 }9 cChapter 14 Endothelial Differentiation of Embryonic Stem Cells 267
$ }+ i8 \* w/ Z7 N7 [Peter Oettgen
6 s0 t$ l: l1 Y, ]Part 5 Hepatic Differentiation 277' ~0 j+ w! w7 {
Chapter 15 Stem Cells for HUMAN Hepatic Tissue Engineering 2791 y  ^: Z4 R' u# E: Y( F# s8 u
N.I. Nativ, M.A. Ghodbane, T.J. Maguire,+ R2 ]- ?9 f# q; r- h2 q- {0 l1 M
F. Berthiaume and M.L. Yarmush
  F  [) o) F& H+ w& M2 `Chapter 16 Hepatic Differentiation of Human Embryonic and Induced
( F+ w: \  \3 R/ Y8 a6 rPluripotent Stem Cells for Regenerative Medicine 303
( b9 V5 Y3 u, p; GToshio Miki+ [6 m' n6 }! s* v: U0 Q, }
Part 6 Osteogenic Differentiation 321
/ S" M( U  \1 ]% n$ o* X9 LChapter 17 Osteogenesis from Pluripotent Stem Cells:3 Q) ^' z) _& b, K" G
Neural Crest or Mesodermal Origin? 323
  W; Z* \# ^6 {5 @& L% X7 s2 B& IKevin C. Keller and Nicole I. zur Nieden
) l3 @& V* i: L+ S" j+ g2 JContents VII; u# G& N4 D& F
Part 7 Pluripotent Alternatives –% K1 V0 ]" q/ v0 v5 U
Induced Pluripotent Stem Cells (iPSCs) 349
( v! D* Y& n6 y# {3 r) K/ DChapter 18 The Past, Present and Future of
# c; i. @7 {- mInduced Pluripotent Stem Cells 351
- ^0 a: X5 F, FKoji Tanabe and Kazutoshi Takahashi& e6 Y. `7 }$ ?3 }+ t- }3 ]$ a" O
Chapter 19 New Techniques in the Generation& O' _. u" s' ~2 G+ W
of Induced Pluripotent Stem Cells 373
* _9 S2 W1 R- N6 m% p8 oRaymond C.B. Wong, Ellen L. Smith and Peter J. Donovan
* S) J7 ]+ i( i" M9 AChapter 20 Generation of ICM-Type Human iPS Cells
; H9 O3 i  L( u! ?from CD34+ Cord Blood Cells 3998 Y/ V) ]2 _5 @9 ?, }8 M
Naoki Nishishita, Noemi Fusaki and Shin Kawamata
* A6 I, I6 `4 E+ zChapter 21 Modelling of Neurological Diseases0 \6 }. |0 H" L- s
Using Induced Pluripotent Stem Cells 413( R" X* J4 C# N
Oz Pomp, Chen Sok Lam, Hui Theng Gan,
, z& W) Q/ S' O0 ESrinivas Ramasamy and Sohail Ahmed' M9 r9 l, P! o5 A# x9 y% [8 H
Part 8 Pluripotent Alternatives - Other Cell Sources 431
' S0 ^- f0 k  mChapter 22 Very Small Embryonic/Epiblast-Like Stem Cells (VSELs)3 i- D6 p5 G1 ?( |
Residing in Adult Tissues and Their Role# p1 v7 \7 d8 `
in Tissue Rejuvenation and Regeneration 433
$ ^1 p9 w- ]" Y/ j( xDong-Myung Shin, Janina Ratajczak,
: P* {9 N# Z2 k% fMagda Kucia and Mariusz Z. Ratajczak
$ A8 O! H7 \  a0 e+ z' }Chapter 23 Multipotent Dental Stem Cells:
: b" y3 s5 v; ?1 l( j$ V7 m) lAn Alternative Adult Derived Stem
4 ~) Q* ^  q4 _* N0 P+ TCell Source for Regenerative Medicine 451& n) N1 T/ E' ~0 k; B  l3 c
Tammy Laberge and Herman S. Cheung
6 O3 z5 t; d+ C  M- ]; k9 PChapter 24 Pluripotent Stem Cells from Testis 473
7 ?" _% E6 b3 z+ g  `Sandeep Goel and Hiroshi Imai
. R- Z+ X( e# \0 d. p5 u, @0 YChapter 25 Amniotic Fluid Stem Cells 493
' y: z% n& i8 {# sGianni Carraro, Orquidea H. Garcia,
, J# v/ _% Q& n7 ~+ U. [3 fLaura Perin, Roger De Filippo and David Warburton& t$ t1 b9 r/ i. F
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Differentiation and Pluripotent Alternatives

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