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2010年Science杂志总结出的10大科技进展中，有关细胞重编程的描述：
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Souped-Up Cellular Reprogramming
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5 }; {& ^& ?( N/ AChanging a cell’s fate by adding extra copies of a few genes has become routine in labs around the world. The technique,
# T+ ~ @! d2 ^9 I. B* R; z; \known as cellular reprogramming, allows scientists to turn back a cell’s developmental clock, making adult cells behave
& E6 Z+ Z' m F9 [9 `, Clike embryonic stem cells (see “Insights of the Decade,” p. 1612). The resulting induced pluripotent stem cells (iPSCs) n& `, A: X, \0 A2 v5 ]* T9 @
are helping scientists to study a variety of diseases and may someday help to treat patients by supplying them with genetically
1 b4 m2 \# f- d3 Rmatched replacement cells.8 ~) e8 I/ b) y% k9 H! N
This year, scientists found a way to make reprogramming even easier using synthetic RNA molecules. The synthetic RNAs! [. [3 `* Y% C) t& ^1 z) }6 m! M1 h0 d
are designed to elude the cell’s antiviral defenses, which usually attack foreign RNA. The technique is twice as fast and 100 times5 o K( i( d3 a2 s* T# A9 B" N
as efficient as standard techniques. And because the RNA quickly breaks down, the reprogrammed cells are genetically identical
. g4 N, T. ~3 {9 m$ p% C# Mto the source cells, making them potentially safer for use in therapies.
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Early evidence suggests that the RNA approach reprograms the cell more thoroughly than other methods do, yielding a6 B* k/ ~' W' M9 s7 e( E+ I1 D
closer match to embryonic stem cells. The method can also prompt cells to become nonembryonic cell types. By inserting synthetic; A5 i j4 ]- C. c |% o$ J6 V! j
RNA into a cell that codes for a key gene in muscle tissue, for example, the researchers could turn both fi broblasts and iPSCs into muscle cells.
& O! r2 O7 F; c! N3 n- k( ]4 {6 E编者对具有调控的RNA分子在细胞重编程中的作用的预言，这么快就实现了，呵呵，说不定就是文章的作者提前透露出来的消息呢。
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发表于 2011-4-8 09:25
发表于 2011-4-8 21:20
