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本帖最后由 细胞海洋 于 2013-4-23 11:11 编辑 ) r, g$ w" T/ ^* A1 z7 P7 p
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Volume 38, Issue 4
& C" Y3 r1 x) ~On the cover: The lymphoid stromal microenvironment is required to provide # v k+ E8 i, _" Q: x( U2 t0 D% c* e, v
structural support for lymphocyte migration, localization, and function. By fate / r9 g) X1 o( K; N$ X/ |% ~4 q
mapping analysis, Castagnaro et al. (pages 782–791) show that mature stromal
5 c: C" A7 b8 B& A" Vcells originate from embryonic mesenchymal progenitors of the
$ w8 R6 O& }/ i; S kNkx2-5+Islet1+ lineage. This study suggests the presence
9 q# P ^" d5 x7 {' x {) |. k, gof multipotent progenitors that generate distinct stromal cell subsets and
8 o. |3 g% p0 h' D( m7 [3 j$ Vparticipate in lymphoid tissue remodeling and repair. The cover image depicts a
. f8 H6 Q3 T5 `7 W6 a) Ohierarchical model for generating the stromal microenvironment in development + a$ M: t4 J" A# S, c) k3 x
and organ regeneration whereby the roots represent the stromal progenitors 5 c9 o( s( e0 C! O
giving rise to fibroblastic reticular cells, follicular dendritic cells, and
' O9 O- J/ u- f7 G; h* N0 Xmarginal reticular cells as represented by the leaves. Image by Laura Castagnaro
! q2 P* F9 g4 M; Y+ w: _( H* `/ Band Samir Khadem.
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发表于 2013-4-22 20:01
