日本自然科学研究机构基础生物学研究所科学家发现精子能“返老还童”（附原文）

Hongwu

Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment
) e0 W' O, n" ^; nToshinori Nakagawa,1,* Manju Sharma,2 Yo-ichi Nabeshima,1 Robert E. Braun,2 Shosei Yoshida1,3,4,
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Stem cells support tissue maintenance by balancing self-renewal and differentiation. In mice, it is believed that a homogeneous stem cell population of single spermatogonia supports spermatogenesis, and that differentiation, which is accompanied by the formation of connected cells (cysts) of increasing length, is linear and nonreversible. We evaluated this model with the use of lineage analysis and live imaging, and found that this putative stem cell population is not homogeneous. Instead, the stem cell pool that supports steady-state spermatogenesis is contained within a subpopulation of single spermatogonia. We also found that cysts are not committed to differentiation and appear to recover stem cell potential by fragmentation, and that the fate of individual spermatogonial populations was markedly altered during regeneration after damage. Thus, there are multiple and reversible paths from stem cells to differentiation, and these may also occur in other systems. . T2 ^2 I4 E% S6 U# W. e
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