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A hairy kinase

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发表于 2009-3-6 08:55 |显示全部帖子
To get a hairy mouse, look to the Sgk3 kinase. So say Alonso et al. on page 559.
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The control of hair follicle growth has been an enigma for cell biologists. While growth factors such as EGF are known for their ability to stimulate proliferation in epithelial cells, EGF causes hair loss. In addition, the downstream signals that control hair growth are largely unknown. Now, an Akt relative called Sgk3 is identified as a hair growth kinase.9 }- R% H' d3 K+ c. g

0 w. |* x, X5 a" }9 mSimilar to EGF treatment, loss of Sgk3 in mice results in short, thin hair coats due to problems in follicle growth. The engine for hair production is the hair bulb, which is composed of epithelial matrix cells at the follicle base. These cells, derived from follicle stem cells, differentiate to produce the hair. Throughout normal adult life, hair follicles undergo cycles of growth and shrinkage. In the sgk3 mutant, the shrinking phase begins prematurely, before the hair has fully developed.( t% S1 [# K& t
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Alonso et al. find that apoptosis, cell cycling, and differentiation timing are all roughly normal in the sgk3 mutant matrix. Recruitment of progenitors into the matrix, however, seems to be impaired, thus accelerating the exhaustion of the matrix cell supply and initiation of shrinkage. The question now is which compartment uses the kinase to control the maintenance of the matrix. It might be the matrix itself, the stem cell niche, or the outer root sheath connecting the two compartments.(Mice lacking Sgk3 (right) have thin coat)

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发表于 2015-5-29 16:43 |显示全部帖子
有才的不在少数啊  

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发表于 2015-6-10 08:17 |显示全部帖子
人之所以能,是相信能。  

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发表于 2015-6-24 14:48 |显示全部帖子
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好啊,,不错、、、、  

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发表于 2015-8-21 13:27 |显示全部帖子
青春就像卫生纸。看着挺多的,用着用着就不够了。  

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发表于 2015-8-26 08:18 |显示全部帖子
说嘛1~~~想说什么就说什么嘛~~  

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发表于 2015-8-28 10:28 |显示全部帖子
我仅代表干细胞之家论坛前来支持,感谢楼主!  

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发表于 2015-9-9 14:43 |显示全部帖子
好人一个  

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发表于 2015-9-29 23:42 |显示全部帖子
…没我说话的余地…飘走  

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发表于 2015-10-20 08:43 |显示全部帖子
顶.支持,路过.....  
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