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New route to A?

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发表于 2009-3-6 08:44 |显示全部帖子
A? had previously been localized to nebulous endocytic compartments. Based on evidence that AVs in liver contain the A? precursor, Yu et al. wondered whether autophagocytosis also creates A?. They found that isolated neuronal AVs contained A? and were highly enriched for the enzymes that create it. AVs were a major source of intracellular A?, which is increasingly thought to be more toxic than the secreted form.
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2 ^9 O2 y5 |4 j. i0 l. z% H0 lHealthy brain tissue rarely contained AVs and thus accumulated little A?. But the authors found that neurons of brains in the early stages of AD, before neurodegeneration was apparent, contained unusually high numbers of AVs. These compartments normally fuse with degradative lysosomes, which might get rid of any A?, but this fusion apparently failed in the diseased neurons.
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High levels of A?, as in AD neurons, were seen in cells in which the authors used nutrient starvation to induce autophagy. Suppressing autophagy, in contrast, decreased A? production. If A? oligomers create holes in membranes, as has been proposed, caustic or partially degraded AV proteins might escape into the cytoplasm. Along with A?, these troublemakers might be dealt with by therapeutic treatments that promote their digestion, such as AV acidification.(On page 87, Yu et al. reveal that autoph)

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发表于 2015-5-28 09:18 |显示全部帖子
有才的不在少数啊  

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发表于 2015-7-22 14:54 |显示全部帖子
看看..  

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发表于 2015-8-12 21:56 |显示全部帖子
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偶啥时才能熬出头啊.  

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发表于 2015-8-28 14:58 |显示全部帖子
做对的事情比把事情做对重要。  

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发表于 2015-9-13 08:05 |显示全部帖子
给我一个女人,我可以创造一个民族;给我一瓶酒,我可以带领他们征服全世界 。。。。。。。。。  

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发表于 2015-9-18 15:55 |显示全部帖子
呵呵 高高实在是高~~~~~  

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发表于 2015-10-8 00:06 |显示全部帖子
挤在北京,给首都添麻烦了……  

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发表于 2015-10-22 19:01 |显示全部帖子
继续查找干细胞研究资料

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发表于 2015-10-23 21:58 |显示全部帖子
谢谢分享  
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