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Pulling out gene silencers

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发表于 2009-3-6 08:21 |显示全部帖子
Baur/Elsevier
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- U5 `. b0 }1 t/ kHeterochromatin's repressive hold on DNA transcription can only be relinquished when activators enter the nucleus. Or so the theory goes. But now Vanessa Witte, Andreas Baur (University of Erlangen, Germany), and colleagues find that a heterochromatin component can be pulled from the nucleus by both the HIV protein Nef and activated integrins.& ?4 O  C/ g6 r

5 a6 {4 ]3 u1 i9 K( E% M"This is a really new concept〞that chromatin-associated proteins are shuttling," says Baur. The shuttling Eed protein, a polycomb group (PcG) heterochromatin factor, is captured at the plasma membrane by either membrane-associated Nef or activated integrins.
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Eed first came to the attention of the German group as a Nef-binding protein. Injection of Nef into cells led to translocation of Eed out of nuclei to the cytoplasm. This reduces or eliminates the association of Eed with the integrated HIV DNA and increases HIV transcription. During an infection, these effects may be mediated by the small amount of Nef that the virus brings in with it.
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The interaction between Eed and integrins has been noted before, but Witte et al. are the first to demonstrate that Eed shuttles out of the nucleus and binds to the plasma membrane after integrin activation, thus increasing HIV transcription.
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, y- P0 b6 c  O; kThe capture of Eed at signaling complexes may, Baur suggests, ensure that the nucleus is derepressed even before it receives activating signals from the plasma membrane. Other signaling complexes may use the same dual strategy.
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Witte, V., et al. 2004. Mol. Cell. 13:179–190.(Only in cells with Nef (left) does Eed s)

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发表于 2015-5-31 10:18 |显示全部帖子
真好。。。。。。。。。  

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发表于 2015-7-4 08:56 |显示全部帖子
照你这么说真的有道理哦 呵呵 不进沙子馁~~~  

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发表于 2015-8-2 21:35 |显示全部帖子
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声明一下:本人看贴和回贴的规则,好贴必看,精华贴必回。  

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发表于 2015-8-19 14:54 |显示全部帖子
今天临床的资料更新很多呀

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发表于 2015-8-20 22:17 |显示全部帖子
看或者不看,贴子就在这里,不急不忙  

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发表于 2015-9-8 22:27 |显示全部帖子
努力,努力,再努力!!!!!!!!!!!  

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发表于 2015-10-3 21:06 |显示全部帖子
厉害!强~~~~没的说了!  

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发表于 2015-10-8 15:16 |显示全部帖子
回帖是种美德.  

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发表于 2015-11-7 11:43 |显示全部帖子
真是天底下好事多多  
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