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One brain fits all

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发表于 2009-3-6 00:15 |显示全部帖子
Heisenberg/Elsevier* O: v7 F, Z* u8 p
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Martin Heisenberg (University of Würzburg, Germany) is attempting to move fly neurobiology from the qualitative to the quantitative. With his colleagues, Heisenberg has constructed a Drosophila standard brain. He hopes that researchers will contribute to the model by adding expression patterns of their favorite genes and will use the model to characterize mutants.+ w# E0 Y- ?* |% e
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"Conceptually, anatomy has always been single case studies," says Heisenberg. A few years ago he saw an opportunity to change this situation. Scientists now had the computing power and confocal microscopy expertise needed to compare multiple, entire fly brains. When Heisenberg did so, he found that the brain images could be superimposed with only a 15% standard deviation, thus yielding the standard brain.This was the standard brain for the Canton-S fly strain, which has been wandering around food vials for over 1,000 generations. But when Heisenberg made a standard brain for the more recently tamed Lindelbach strain, he found that two brain regions implicated in flight control were 10–15% larger in Lindelbach than those in Canton-S, whereas a brain region used in walking control was 10% smaller. Apparently, fly researchers have been studying an organism that is better adapted to sauntering than soaring.
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8 M9 G( q: _. ^6 c* ENow that the standard brain has been established, others can contribute to it by using a fairly standard computer set-up. Brain whole-mounts and imaging tend to be fast, but a single brain can take 2 days to analyze because of the time needed for manual outlining and assigning of each brain region. The two days should be reduced to several hours by a program〞still under development〞that will do most of the outlining automatically.; ?2 V% H. N* _) _9 [

: Y$ _' y) B6 QAlthough the protocol may be too cumbersome for large scale mutant screens, Heisenberg believes that numerous labs can contribute expression patterns to the model. "Standardization of these gene expression patterns with respect to each other will help us make sense of them," he says. "We need a link between the gene level and the anatomic level."
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Reference:
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# [6 ~  [. O1 z- ^Rein, K., et al. 2002. Curr. Biol. 12:227–231.(The fly standard brain.)

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发表于 2015-6-5 12:17 |显示全部帖子
感谢党和人民的关爱~~~  

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发表于 2015-6-7 16:35 |显示全部帖子
终于看完了~~~  

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发表于 2015-7-18 10:42 |显示全部帖子
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太棒了!  

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发表于 2015-8-13 18:52 |显示全部帖子
想都不想,就支持一下  

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发表于 2015-8-13 21:26 |显示全部帖子
我起来了 哈哈 刚才迷了会  

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发表于 2015-8-19 11:19 |显示全部帖子
我有家的感觉~~你知道吗  

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发表于 2015-8-22 21:10 |显示全部帖子
不错,支持下  

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发表于 2015-9-13 08:43 |显示全部帖子
这个贴好像之前没见过  

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发表于 2015-10-27 13:01 |显示全部帖子
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