干细胞可能会引发肿瘤(附原文)

细胞海洋

Implanted adipose progenitor cells as physicochemical regulators of breast cancer
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0 n2 a1 C1 U1 i6 n8 s6 rEmily M. Chandlera,1, Bo Ri Seoa,1, Joseph P. Califanoa, Roberto C. Andresen Eguiluzb, Jason S. Leea, Christine J. Yoona, David T. Timsa, James X. Wanga, Le Chengc, Sunish Mohananc, Mark R. Buckleyd, Itai Cohend, Alexander Yu Nikitinc, Rebecca M. Williamsa, Delphine Gourdonb, Cynthia A. Reinhart-Kinga, and Claudia Fischbach6 X+ f* z) y9 O6 ?7 F
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Multipotent adipose-derived stem cells (ASCs) are increasingly used for regenerative purposes such as soft tissue reconstruction following mastectomy; however, the ability of tumors to commandeer ASC functions to advance tumor progression is not well understood. Through the integration of physical sciences and oncology approaches we investigated the capability of tumor-derived chemical and mechanical cues to enhance ASC-mediated contributions to tumor stroma formation. Our results indicate that soluble factors from breast cancer cells inhibit adipogenic differentiation while increasing proliferation, proangiogenic factor secretion, and myofibroblastic differentiation of ASCs. This altered ASC phenotype led to varied extracellular matrix (ECM) deposition and contraction thereby enhancing tissue stiffness, a characteristic feature of breast tumors. Increased stiffness, in turn, facilitated changes in ASC behavior similar to those observed with tumor-derived chemical cues. Orthotopic mouse studies further confirmed the pathological relevance of ASCs in tumor progression and stiffness in vivo. In summary, altered ASC behavior can promote tumorigenesis and, thus, their implementation for regenerative therapy should be carefully considered in patients previously treated for cancer.( ^  P$ y" Q9 `+ i! q1 X0 R5 i, Y
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echowdk

回复 xbqian 的帖子
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评论的好精辟啊。。。

JOEL

回复 Donnies 的帖子5 d, K' w8 t& x% R$ ^2 b6 ]; v+ A

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/ s; q& O4 v; q4 A  fQuotation ------"...而干细胞的数量是随着年龄的增加而减少的，..."
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6 _2 @; \" t9 A# e2 x# Q9 T  LI think so sometimes.
, A# D6 n! M# Z4 t7 B3 ]As a simple principle known for us is that it is much slower and more difficult comparatively that an damage or injury of the very aged people is clinically healed to a full restoration or recovery. Questions:
! d; ]  T+ g. y6 u/ ~% {I, Does it mean that at least it may related to the quality and quantity of ASC in the body, between which and degenration of human body is a direct ratio?
% c, o; \" @+ e7 C0 d3 BII, And what is some information on the natural life span of ASC in the human body ? So far, how much do we know through SCR?
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I would appreciate it very much if you kindly response the questions.

Donnies

"between which and degenration of human body is a direct ratio? "中的“degenration”指的是“degeneratiaon”？

Donnies

回复 JOEL 的帖子1 q7 v. [7 ~0 D; W

0 M  `2 |* J6 ~4 }0 h"between which and degenration of human body is a direct ratio? "中的“degenration”指的是“degeneratiaon”？   ]: G, T+ F+ Q# ?) j) F

cell1314

警钟啊警钟

cell1314

真可恶，又是一个错误的PDF

细胞海洋

回复 cell1314 的帖子
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7 d; W; V% q7 n: K3 q* K; _8 b3 x下载不要使用迅雷 ie浏览器默认下载即可$ ~* Z( r& l5 `( v% M

JOEL

回复 Donnies 的帖子
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. l) G2 {) O8 r$ [Oh, yes, it is "degeneration."
/ D( z! h! H& n- h0 J( _! h4 qSorry for this inconvenience. Thank you and appreciate it.9 M! \* L- E# p  d

Donnies

回复 JOEL 的帖子
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R U  a foreigner？