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DNA甲基化与转录调控及肿瘤发生相关的经典文献   [复制链接]

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发表于 2012-1-22 12:06 |只看该作者 |倒序浏览 |打印
    博士期间对DNA甲基化与肿瘤的发生,特别是在影响一些重要基因的转录方面做了大量的工作。: f5 u/ J' e& P3 b
做了一个系统的基因列表的总结,主要分成了3个step4 {; ?6 a, p+ W3 I7 E4 ~
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1,总结文献,查找受甲基化调控的基因转录,发现了2132个基因受甲基化调控,当然很显然这只是一小部分,很多基因还在陆续被发表出来  O6 w; V7 R2 |. C+ P! z% T
2,利用5-zaz处理的芯片数据,进行数据挖掘,发现了600多个基因,表达上调,这些基因很有可能受甲基化调控6 j/ ^9 F/ ^4 i# {% W# h
3,利用甲基化芯片和表达芯片(同一样本)进行关联分析,这种方法发现了29-00多个基因,可能受甲基化调控
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显然面对这么大量的数据,如果你仍旧很通过实验证实出一个及基因受甲基化调控,。在科学进步中的贡献之渺小
& g, v7 ]% \) i9 l! q/ D' E6 Y所以不提倡国人做这样纯体力的工作,由于中华民族勤劳善良的特点,实际上我们做了很多纯体力的工作,但这些工作贡献率又极低6 a, `+ J/ a2 N$ O9 }( h) M5 k
3 m$ x% A  O7 E$ Y% R
为此,大力提倡我亲爱的战友=干细胞之家=的朋友们,多做贡献率高的文章,三大原则:  T& C2 ?3 R/ w. N) X8 |# S
5 d+ S; ^" ~" C+ z' r! _
1,能用最小的精力,做最有意思的事情) `3 \' D. o* n% K$ Z7 T
2,不发烂文章(特别是实验类的烂文章,这些都是那中国最善良劳动纳税人的钱打水漂)
: ]) L' Q9 B/ S/ r5 A& q3,鼓励多发生物信息学,特别是数据库的文章,一方面不花钱,另一方面可以提高咱们国家生命医学的竞争力- _/ n, m6 @  K4 ~+ \* w4 n

2 d. U  g. y2 @' g& o& L3 ^7 _3 I. a- r最后附件是我所提到的0 J# k/ y8 W7 N9 n8 e
1,总结文献,查找受甲基化调控的基因转录,发现了2132个基因受甲基化调控,当然很显然这只是一小部分,很多基因还在陆续被发表出来/ S/ m5 R/ ]$ C( Z
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发表于 2012-1-22 12:10 |只看该作者
上述文章的标题如下:1 H9 f) W  t2 \" a# H7 y
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Rody, A., Holtrich, U., Solbach, C., Kourtis, K., von Minckwitz, G., Engels, K., Kissler, S., Gatje, R., Karn, T., and Kaufmann, M. (2005). Methylation of estrogen receptor beta promoter correlates with loss of ER-beta expression in mammary carcinoma and is an early indication marker in premalignant lesions. Endocr Relat Cancer 12, 903-916.) U/ G' E. ^+ {4 B+ b
Rollin, J., Iochmann, S., Blechet, C., Hube, F., Regina, S., Guyetant, S., Lemarie, E., Reverdiau, P., and Gruel, Y. (2005). Expression and methylation status of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer. Br J Cancer 92, 775-783.' f: B+ @: P+ A7 h/ [7 Z
Rossler, J., Stolze, I., Frede, S., Freitag, P., Schweigerer, L., Havers, W., and Fandrey, J. (2004). Hypoxia-induced erythropoietin expression in human neuroblastoma requires a methylation free HIF-1 binding site. J Cell Biochem 93, 153-161.( c+ g* V$ L4 t3 ^
Rotter, A., Asemann, R., Decker, A., Kornhuber, J., and Biermann, T. (2011). Orexin expression and promoter-methylation in peripheral blood of patients suffering from major depressive disorder. J Affect Disord 131, 186-192.
% @, N& L7 M. ~Rougeulle, C., Navarro, P., and Avner, P. (2003). Promoter-restricted H3 Lys 4 di-methylation is an epigenetic mark for monoallelic expression. Hum Mol Genet 12, 3343-3348.
% f' w0 x1 y. q* K/ ]0 F$ WRousseau, K., Byrne, C., Griesinger, G., Leung, A., Chung, A., Hill, A.S., and Swallow, D.M. (2007). Allelic association and recombination hotspots in the mucin gene (MUC) complex on chromosome 11p15.5. Annals of Human Genetics 71, 561-569.
7 N0 S. l& q* V6 J; @: hRubinstein, J.C., Tran, N., Ma, S., Halaban, R., and Krauthammer, M. (2010). Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma. BMC Med Genomics 3, 4.# N; A) Q  j7 k4 K! A
Ruden, D.M., Xiao, L., Garfinkel, M.D., and Lu, X. (2005). Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer. Hum Mol Genet 14 Spec No 1, R149-155.5 [" @! B# R  W1 B5 j+ X
Ruebel, K.H., Jin, L., Qian, X., Scheithauer, B.W., Kovacs, K., Nakamura, N., Zhang, H., Raz, A., and Lloyd, R.V. (2005). Effects of DNA methylation on galectin-3 expression in pituitary tumors. Cancer Res 65, 1136-1140.
5 v! G1 W+ n3 C! t: \( p$ IRunstadler, J.A., Saila, H., Savolainen, A., Leirisalo-Repo, M., Aho, K., Tuomilehto-Wolf, E., Tuomilehto, J., and Seldin, M.F. (2004). HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC. Genes and Immunity 5, 562-571.
3 k3 i& ^# b4 G  Q' W3 e5 B) vSachan, M., and Raman, R. (2006). Developmental methylation of the regulatory region of HoxB5 gene in mouse correlates with its tissue-specific expression. Gene 380, 151-158.7 O% B# e  r# H9 T- F8 y4 Z
Sadr-Nabavi, A., Ramser, J., Volkmann, J., Naehrig, J., Wiesmann, F., Betz, B., Hellebrand, H., Engert, S., Seitz, S., Kreutzfeld, R., et al. (2009). Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker. Int J Cancer 124, 1727-1735.
( n5 j6 Z9 ^7 p0 J6 zSaito, Y., Kanai, Y., Nakagawa, T., Sakamoto, M., Saito, H., Ishii, H., and Hirohashi, S. (2003). Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int J Cancer 105, 527-532.
* [0 C, h; F0 O5 f% ]  cSaito, Y., Kanai, Y., Sakamoto, M., Saito, H., Ishii, H., and Hirohashi, S. (2001). Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 33, 561-568.
+ U5 Q( J) R0 D8 vSamuelsson, J.K., Alonso, S., Yamamoto, F., and Perucho, M. (2010). DNA fingerprinting techniques for the analysis of genetic and epigenetic alterations in colorectal cancer. Mutat Res 693, 61-76., ]7 x6 b/ P, K* H
San Jose-Eneriz, E., Agirre, X., Roman-Gomez, J., Cordeu, L., Garate, L., Jimenez-Velasco, A., Vazquez, I., Calasanz, M.J., Heiniger, A., Torres, A., et al. (2006). Downregulation of DBC1 expression in acute lymphoblastic leukaemia is mediated by aberrant methylation of its promoter. Br J Haematol 134, 137-144.
. I0 J  \2 \7 {, p2 FSanders, V.M. (2006). Epigenetic regulation of Th1 and Th2 cell development. Brain Behavior and Immunity 20, 317-324.
5 R, W! x8 F2 Z- s' E1 LSanso, M., Gogol, M., Ayte, J., Seidel, C., and Hidalgo, E. (2008). Transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation. Eukaryotic Cell 7, 826-835.
% }% `1 ?' @3 Y) ]! |! {Sarnacki, S.H., Marolda, C.L., Noto Llana, M., Giacomodonato, M.N., Valvano, M.A., and Cerquetti, M.C. (2009). Dam methylation controls O-antigen chain length in Salmonella enterica serovar enteritidis by regulating the expression of Wzz protein. J Bacteriol 191, 6694-6700.' O3 s9 ?* B$ b) k) q2 t' Z
Sato, H., Nakamura, Y., and Motokura, T. (2006). Differential 14-3-3 sigma DNA methylation and expression in c-myc- and activated H-ras-transformed cells under r- and K-selection. Cancer Lett 236, 105-114., M1 r' E( ^, L9 d: v0 ~9 i5 W4 |
Sato, M., Horio, Y., Sekido, Y., Minna, J.D., Shimokata, K., and Hasegawa, Y. (2002). The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell lines. Oncogene 21, 4822-4829.; j9 y/ |/ K; Y( n/ |
Satta, R., Maloku, E., Zhubi, A., Pibiri, F., Hajos, M., Costa, E., and Guidotti, A. (2008). Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proc Natl Acad Sci U S A 105, 16356-16361.4 s* _- G9 v5 [! h3 O0 c
Sauer, J., Jang, H., Zimmerly, E.M., Kim, K.C., Liu, Z., Chanson, A., Smith, D.E., Mason, J.B., Friso, S., and Choi, S.W. (2010). Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon. Br J Nutr 104, 24-30.
: U9 k$ r0 y/ `5 D$ z2 q( t, NSawan, C., Vaissiere, T., Murr, R., and Herceg, Z. (2008). Epigenetic drivers and genetic passengers on the road to cancer. Mutat Res 642, 1-13.
: V- J2 A4 {5 `8 ?Scarpino, S., Di Napoli, A., Rapazzotti-Onelli, M., Pilozzi, E., and Ruco, L. (2004). Papillary carcinoma of the thyroid: methylation is not involved in the regulation of MET expression. Br J Cancer 91, 703-706.
7 C* R, |- Y) s4 lSchaefer, M., Meusburger, M., and Lyko, F. (2007). Non-mammalian models for epigenetic analyses in cancer. Hum Mol Genet 16 Spec No 1, R1-6.
2 @+ `; J4 D5 D' j, ]1 {* LSchilling, E., El Chartouni, C., and Rehli, M. (2009). Allele-specific DNA methylation in mouse strains is mainly determined by cis-acting sequences. Genome Res 19, 2028-2035.
# e7 B" ^$ F% v1 g" e# y. D1 |9 fSchramm, M., Wrobel, C., Born, I., Kazimirek, M., Pomjanski, N., William, M., Kappes, R., Gerharz, C.D., Biesterfeld, S., and Bocking, A. (2011). Equivocal cytology in lung cancer diagnosis: Improvement of diagnostic accuracy using adjuvant multicolor FISH, DNA-image cytometry, and quantitative promoter hypermethylation analysis. Cancer Cytopathol.2 W! C) ^* V, v* `7 j/ }7 ^
Schulz, W.A., and Hoffmann, M.J. (2009). Epigenetic mechanisms in the biology of prostate cancer. Semin Cancer Biol 19, 172-180.# B. g8 Q6 L0 I  K, w
Schulze, T.G., Zhang, K., Chen, Y.S., Akula, N., Sun, F.Z., and McMahon, F.J. (2004). Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome. Human Molecular Genetics 13, 335-342.
' @: i$ q, a8 u: _$ }  hScott, A., Hasegawa, H., Sakurai, K., Yaron, A., Cobb, J., and Wang, F. (2011). Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. J Neurosci 31, 6741-6749.
5 l0 \' N) I2 {. A+ pSebastian, S., Sreenivas, P., Sambasivan, R., Cheedipudi, S., Kandalla, P., Pavlath, G.K., and Dhawan, J. (2009). MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation. Proc Natl Acad Sci U S A 106, 4719-4724.  a' t: b' B- {6 m
Seo, S.Y., Kim, E.O., and Jang, K.L. (2008). Epstein-Barr virus latent membrane protein 1 suppresses the growth-inhibitory effect of retinoic acid by inhibiting retinoic acid receptor-beta2 expression via DNA methylation. Cancer Lett 270, 66-76.% W) _: H) P8 u4 N
Sepulveda, A.R., Yao, Y., Yan, W., Park, D.I., Kim, J.J., Gooding, W., Abudayyeh, S., and Graham, D.Y. (2010). CpG methylation and reduced expression of O6-methylguanine DNA methyltransferase is associated with Helicobacter pylori infection. Gastroenterology 138, 1836-1844.
, y$ N  v+ c( {Serizawa, N., Horiuchi, T., and Kobayashi, T. (2004). Transcription-mediated hyper-recombination in HOT1. Genes to Cells 9, 305-315.5 H/ i8 M9 C! F* M0 J2 k0 y- I
Seroussi, E., and Yakobson, E. (2010). Bovine mtDNA D-loop haplotypes exceed mutations in number despite reduced recombination: an effective alternative for identity control. Animal 4, 1818-1822.! c" q; l& j( ?' E  E
Serpa, J., Mesquita, P., Mendes, N., Oliveira, C., Almeida, R., Santos-Silva, F., Reis, C.A., LePendu, J., and David, L. (2006). Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylation. Cancer Lett 242, 191-197.
8 m6 H% A. `$ K* B3 ZSerrano, A., Redondo, M., Tellez, T., Castro-Vega, I., Roldan, M.J., Mendez, R., Rueda, A., and Jimenez, E. (2009). Regulation of clusterin expression in human cancer via DNA methylation. Tumour Biol 30, 286-291.
2 v3 \/ ^0 c) z4 qSeverin, P.M., Zou, X., Gaub, H.E., and Schulten, K. (2011). Cytosine methylation alters DNA mechanical properties. Nucleic Acids Res.1 e6 @+ U9 q. i+ C
Shaffer, J.M., and Smithgall, T.E. (2009). Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer. Genes Chromosomes Cancer 48, 272-284.
# ]- p# n+ A: f; b2 H4 k- IShaikh, T.H., O'Connor, R.J., Pierpont, M.E., McGrath, J., Hacker, A.M., Nimmakayalu, M., Geiger, E., Emanuel, B.S., and Saitta, S.C. (2007). Low copy repeats mediate distal chromosome 22q11.2 deletions: Sequence analysis predicts breakpoint mechanisms. Genome Research 17, 482-491.! Z! ]7 Q) [) z& y6 r" l% G
Shao, P., Yang, J.H., Zhou, H., Guan, D.G., and Qu, L.H. (2009). Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs. BMC Genomics 10, -.
0 J* k3 B# q( z$ QSharma, A., Heuck, C.J., Fazzari, M.J., Mehta, J., Singhal, S., Greally, J.M., and Verma, A. (2010). DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer. Wiley Interdiscip Rev Syst Biol Med 2, 654-669.
& J4 g# |% u( i1 WShaw, R.J., Hall, G.L., Lowe, D., Liloglou, T., Field, J.K., Sloan, P., and Risk, J.M. (2008). The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression. Arch Otolaryngol Head Neck Surg 134, 251-256.
7 x  }  P) S, kShen, H.M., Nakamura, A., Sugimoto, J., Sakumoto, N., Oda, T., Jinno, Y., and Okazaki, Y. (2006). Tissue specificity of methylation and expression of human genes coding for neuropeptides and their receptors, and of a human endogenous retrovirus K family. Journal of Human Genetics 51, 440-450.* _" v; }6 G% X/ ]# q3 y
Shen, H.M., and Storb, U. (2004). Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proceedings of the National Academy of Sciences of the United States of America 101, 12997-13002.
& T3 L' \: \% _! ~Shi, Q.J., Parks, A.R., Potter, B.D., Safir, I.J., Luo, Y., Forster, B.M., and Peters, J.E. (2008). DNA damage differentially activates regional chromosomal loci for Tn7 transposition in Escherichia coli. Genetics 179, 1237-1250.
2 O' B; P$ E# {7 L* Q9 C) K, \Shiah, S.G., Chang, L.C., Tai, K.Y., Lee, G.H., Wu, C.W., and Shieh, Y.S. (2009). The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma. Oral Oncol 45, e1-8.6 u* C) W1 L4 t- s& u' g
Shibata, D. (2011). Mutation and epigenetic molecular clocks in cancer. Carcinogenesis 32, 123-128.
; p6 f, r: r9 j6 TShieh, Y.S., Shiah, S.G., Jeng, H.H., Lee, H.S., Wu, C.W., and Chang, L.C. (2005). DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma. Cancer 104, 1013-1021.7 S9 P7 b6 i' f9 @" ^& `' y# q9 X
Shigdel, U.K., and He, C. (2008). A new 1'-methylenedisulfide deoxyribose that forms an efficient cross-link to DNA cytosine-5 methyltransferase (DNMT). J Am Chem Soc 130, 17634-17635., f4 G. W5 H/ K5 v% P) [
Shih Ie, M., Nakayama, K., Wu, G., Nakayama, N., Zhang, J., and Wang, T.L. (2011). Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma. Mod Pathol 24, 638-645.
4 o3 P1 o# r+ A0 [! O  z; r* JShima, K., Nosho, K., Baba, Y., Cantor, M., Meyerhardt, J.A., Giovannucci, E.L., Fuchs, C.S., and Ogino, S. (2011). Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. Int J Cancer 128, 1080-1094.
$ K1 T9 r2 P# P* [Shirato, H., Ogawa, S., Nakajima, K., Inagawa, M., Kojima, M., Tachibana, M., Shinkai, Y., and Takeuchi, T. (2009). A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J Biol Chem 284, 733-739.
0 k1 n1 y' |, z' N$ H. [$ R' f* sShirohzu, H., Okabe, T., Gondo, S., Tanaka, T., Ohe, K., Morinaga, H., Kawate, H., Nomura, M., Takayanagi, R., Nawata, H., et al. (2008). Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specific expression. Biochem Biophys Res Commun 369, 862-867." U# B# A  X: u% \
Shoemaker, R., Deng, J., Wang, W., and Zhang, K. (2010). Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res 20, 883-889.
1 n4 q8 w' F5 H" y: ASigalotti, L., Coral, S., Altomonte, M., Natali, L., Gaudino, G., Cacciotti, P., Libener, R., Colizzi, F., Vianale, G., Martini, F., et al. (2002). Cancer testis antigens expression in mesothelioma: role of DNA methylation and bioimmunotherapeutic implications. Br J Cancer 86, 979-982.
$ k+ _, h7 c0 m# l6 CSigalotti, L., Covre, A., Zabierowski, S., Himes, B., Colizzi, F., Natali, P.G., Herlyn, M., and Maio, M. (2008). Cancer testis antigens in human melanoma stem cells: expression, distribution, and methylation status. J Cell Physiol 215, 287-291.1 h$ y: @# ^7 Q3 C4 r
Sigalotti, L., Fratta, E., Coral, S., Cortini, E., Covre, A., Nicolay, H.J., Anzalone, L., Pezzani, L., Di Giacomo, A.M., Fonsatti, E., et al. (2007). Epigenetic drugs as pleiotropic agents in cancer treatment: biomolecular aspects and clinical applications. J Cell Physiol 212, 330-344.
6 N" h, F7 p" `, v. RSigalotti, L., Fratta, E., Coral, S., Tanzarella, S., Danielli, R., Colizzi, F., Fonsatti, E., Traversari, C., Altomonte, M., and Maio, M. (2004). Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2'-deoxycytidine. Cancer Res 64, 9167-9171.& X% N  c3 J# C
Simi, L., Malentacchi, F., Luciani, P., Gelmini, S., Deledda, C., Arvia, R., Mannelli, M., Peri, A., and Orlando, C. (2010). Seladin-1 expression is regulated by promoter methylation in adrenal cancer. BMC Cancer 10, 201.
! T+ ^' r& U( h7 T( \0 N" ySimpson, D.J., Clayton, R.N., and Farrell, W.E. (2002). Preferential loss of Death Associated Protein kinase expression in invasive pituitary tumours is associated with either CpG island methylation or homozygous deletion. Oncogene 21, 1217-1224.8 x! {2 R! e$ c8 h& ^
Singh, S., Shi, T., Duffin, R., Albrecht, C., van Berlo, D., Hohr, D., Fubini, B., Martra, G., Fenoglio, I., Borm, P.J., et al. (2007). Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles. Toxicol Appl Pharmacol 222, 141-151.
; r. Y3 y4 L: H: c( VSingleton, M.R., Dillingham, M.S., Gaudier, M., Kowalczykowski, S.C., and Wigley, D.B. (2004). Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks. Nature 432, 187-193.
# y) Y0 e% k2 \7 `! n+ @3 D( [, ~1 ]Sjahputera, O., Keller, J.M., Davis, J.W., Taylor, K.H., Rahmatpanah, F., Shi, H., Anderson, D.T., Blisard, S.N., Luke, R.H., Popescu, M., et al. (2007). Relational analysis of CpG islands methylation and gene expression in human lymphomas using possibilistic C-means clustering and modified cluster fuzzy density. IEEE/ACM Trans Comput Biol Bioinform 4, 176-189.6 S$ Q" |8 ]! F3 Y4 Y* Q
Smagulova, F., Gregoretti, I.V., Brick, K., Khil, P., Camerini-Otero, R.D., and Petukhova, G.V. (2011). Genome-wide analysis reveals novel molecular features of mouse recombination hotspots. Nature 472, 375-378.; x6 q: e; K; v+ a7 _
Smallwood, S.A., Tomizawa, S.I., Krueger, F., Ruf, N., Carli, N., Segonds-Pichon, A., Sato, S., Hata, K., Andrews, S.R., and Kelsey, G. (2011). Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nat Genet.
* R& ?. d  c' m5 z6 ASmith, A.K., Conneely, K.N., Kilaru, V., Mercer, K.B., Weiss, T.E., Bradley, B., Tang, Y., Gillespie, C.F., Cubells, J.F., and Ressler, K.J. (2011). Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder. Am J Med Genet B Neuropsychiatr Genet.
. X* D2 e; Q5 i, h' f; YSmith, E., Drew, P.A., Tian, Z.Q., De Young, N.J., Liu, J.F., Mayne, G.C., Ruszkiewicz, A.R., Watson, D.I., and Jamieson, G.G. (2005). Metallothionien 3 expression is frequently down-regulated in oesophageal squamous cell carcinoma by DNA methylation. Mol Cancer 4, 42.
" D- v: k: x4 xSmith, L.T., Otterson, G.A., and Plass, C. (2007). Unraveling the epigenetic code of cancer for therapy. Trends Genet 23, 449-456.
. N: F8 m  L) g, q  ISoejima, H., Nakagawachi, T., Zhao, W., Higashimoto, K., Urano, T., Matsukura, S., Kitajima, Y., Takeuchi, M., Nakayama, M., Oshimura, M., et al. (2004). Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer. Oncogene 23, 4380-4388.6 R/ J* ?& k) H1 g, a( W
Solomon, L.A., Berube, N.G., and Beier, F. (2008). Transcriptional regulators of chondrocyte hypertrophy. Birth Defects Res C Embryo Today 84, 123-130.& {  A; e. y1 r1 s
Song, C.X., and He, C. (2011). Bioorthogonal Labeling of 5-Hydroxymethylcytosine in Genomic DNA and Diazirine-Based DNA Photo-Cross-Linking Probes. Acc Chem Res.
$ O" m4 t( d! m0 Z& M7 E9 GSong, C.X., Szulwach, K.E., Fu, Y., Dai, Q., Yi, C., Li, X., Li, Y., Chen, C.H., Zhang, W., Jian, X., et al. (2011). Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol 29, 68-72.2 s* i0 O. k( X; |8 ]! d
South, P.F., Fingerman, I.M., Mersman, D.P., Du, H.N., and Briggs, S.D. (2010). A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression. J Biol Chem 285, 595-607.) r2 P3 `( w+ P0 g5 ~2 H
Spies, M., Dillingham, M.S., and Kowalczykowski, S.C. (2005). Translocation by the RecB motor is an absolute requirement for chi-recognition and RecA protein loading by RecBCD enzyme. Journal of Biological Chemistry 280, 37078-37087.( {+ ?0 y7 W* m* C( ~' O
Stadler, F., Kolb, G., Rubusch, L., Baker, S.P., Jones, E.G., and Akbarian, S. (2005). Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. Journal of Neurochemistry 94, 324-336.) W' K9 I( C; x6 u+ w6 e! d6 ~
Stearns, V., Zhou, Q., and Davidson, N.E. (2007). Epigenetic regulation as a new target for breast cancer therapy. Cancer Invest 25, 659-665.1 n" }. ~  C+ E8 ~1 @: o* r
Stein, G.S., Stein, J.L., Van Wijnen, A.J., Lian, J.B., Montecino, M., Croce, C.M., Choi, J.Y., Ali, S.A., Pande, S., Hassan, M.Q., et al. (2010). Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer. Adv Enzyme Regul 50, 160-167.2 v7 s9 e( B- O8 W- C8 i
Stein, G.S., Zaidi, S.K., Stein, J.L., Lian, J.B., van Wijnen, A.J., Montecino, M., Young, D.W., Javed, A., Pratap, J., Choi, J.Y., et al. (2008). Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer. J Cell Biochem 104, 2016-2026.
5 h# e" X* O1 y: b3 Y& NSteiner, W.W., Davidow, P.A., and Bagshaw, A.T.M. (2011). Important Characteristics of Sequence-Specific Recombination Hotspots in Schizosaccharomyces pombe. Genetics 187, 385-396.9 o4 j# }* _' o1 E4 o
Steiner, W.W., and Smith, G.R. (2005). Optimizing the nucleotide sequence of a meiotic recombination hotspot in Schizosaccharomyces pombe. Genetics 169, 1973-1983.7 Z1 ~8 c1 _5 I8 T' T& }
Steiner, W.W., Steiner, E.M., Girvin, A.R., and Plewik, L.E. (2009). Novel Nucleotide Sequence Motifs That Produce Hotspots of Meiotic Recombination in Schizosaccharomyces pombe. Genetics 182, 459-469.
  A5 j# i3 ^1 P( EStengel, S., Fiebig, U., Kurth, R., and Denner, J. (2010). Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation. Genes Chromosomes Cancer 49, 401-411.2 v7 S/ K! m& K# n% ^* m3 X4 g
Strathdee, G., Ferguson, S., Sim, A., and Brown, R. (2010). DNA methylation does not regulate JUNB expression in CML: comment on "Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia" by Hoshino et al. [Leuk. Res. 33 (2009) 1361-1366]. Leuk Res 34, 685-686./ _9 K& i* T$ x( r, \/ T
Strathdee, G., MacKean, M.J., Illand, M., and Brown, R. (1999). A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene 18, 2335-2341.
! I% t, d( T7 T' k" q- Q0 ^Su, J.M., Yang, B., Wang, Y.S., Li, Y.Y., Xiong, X.R., Wang, L.J., Guo, Z.K., and Zhang, Y. (2011). Expression and methylation status of imprinted genes in placentas of deceased and live cloned transgenic calves. Theriogenology 75, 1346-1359.: V- T4 g; z+ _, J) b
Su, S.Y., Dodson, M.V., Li, X.B., Li, Q.F., Wang, H.W., and Xie, Z. (2009). The effects of dietary betaine supplementation on fatty liver performance, serum parameters, histological changes, methylation status and the mRNA expression level of Spot14alpha in Landes goose fatty liver. Comp Biochem Physiol A Mol Integr Physiol 154, 308-314.9 d' j1 o+ z  x" V! m& w" _
Sun, J.Z., Julin, D.A., and Hu, J.S. (2006). The nuclease domain of the Escherichia coli RecBCD enzyme catalyzes degradation of linear and circular single-stranded and double-stranded DNA. Biochemistry 45, 131-140.
, E: E! D5 a# [( U7 {# jSun, L., Huang, L., Nguyen, P., Bisht, K.S., Bar-Sela, G., Ho, A.S., Bradbury, C.M., Yu, W., Cui, H., Lee, S., et al. (2008). DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Res 68, 2726-2735.
# m4 h1 O4 ~, G, i, j- c' JSurani, M.A. (2001). Reprogramming of genome function through epigenetic inheritance. Nature 414, 122-128.# r6 t) x- }4 d
Surani, M.A., Hayashi, K., and Hajkova, P. (2007). Genetic and epigenetic regulators of pluripotency. Cell 128, 747-762.
" G* y+ {' U# \8 H0 xSuzuki, F., Akahira, J., Miura, I., Suzuki, T., Ito, K., Hayashi, S., Sasano, H., and Yaegashi, N. (2008). Loss of estrogen receptor beta isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in human epithelial ovarian carcinoma. Cancer Sci 99, 2365-2372.8 x% w- z% c$ w! M- j; \
Suzuki, J., Jr., Therrien, J., Filion, F., Lefebvre, R., Goff, A.K., Perecin, F., Meirelles, F.V., and Smith, L.C. (2011a). Loss of methylation at H19 DMD is associated with biallelic expression and reduced development in cattle derived by somatic cell nuclear transfer. Biol Reprod 84, 947-956.1 H* Y2 E( N) @
Suzuki, T., Nakada, M., Yoshida, Y., Nambu, E., Furuyama, N., Kita, D., Hayashi, Y., and Hamada, J. (2011b). The correlation between promoter methylation status and the expression level of O6-methylguanine-DNA methyltransferase in recurrent glioma. Jpn J Clin Oncol 41, 190-196.
6 W- K) o1 y! d6 kSvetlanov, A., Baudat, F., Cohen, P.E., and de Massy, B. (2008). Distinct functions of MLH3 at recombination hot spots in the mouse. Genetics 178, 1937-1945.
+ E' I" k5 O" f3 zSvoboda, P., Stein, P., Filipowicz, W., and Schultz, R.M. (2004). Lack of homologous sequence-specific DNA methylation in response to stable dsRNA expression in mouse oocytes. Nucleic Acids Res 32, 3601-3606.! J# L% v5 U- @% c& H) x- C4 |
Swisher, E.M., Gonzalez, R.M., Taniguchi, T., Garcia, R.L., Walsh, T., Goff, B.A., and Welcsh, P. (2009). Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas. Mol Cancer 8, 48.* i/ e4 k- v4 X- Z9 V1 C
Szekvolgyi, L., and Nicolas, A. (2010). From meiosis to postmeiotic events: homologous recombination is obligatory but flexible. Febs Journal 277, 571-589.
9 I. k8 ~0 ~1 }& L1 g- JSzwagierczak, A., Brachmann, A., Schmidt, C.S., Bultmann, S., Leonhardt, H., and Spada, F. (2011). Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5-hydroxymethylcytosine. Nucleic Acids Res.
. w6 G  J9 X/ X  R# t: N; o# s' ySzwagierczak, A., Bultmann, S., Schmidt, C.S., Spada, F., and Leonhardt, H. (2010). Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res 38, e181.
7 f& b0 t1 _+ A9 u7 T: x9 U. uSzyf, M., Weaver, I.C., Champagne, F.A., Diorio, J., and Meaney, M.J. (2005). Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat. Front Neuroendocrinol 26, 139-162.
' p4 V$ R% Q: W3 u) {! H! aTakai, D., Yagi, Y., Wakazono, K., Ohishi, N., Morita, Y., Sugimura, T., and Ushijima, T. (2001). Silencing of HTR1B and reduced expression of EDN1 in human lung cancers, revealed by methylation-sensitive representational difference analysis. Oncogene 20, 7505-7513.- d$ i7 t$ u2 o8 T4 f) G! O  X
Tan, I.K., Mackin, L., Wang, N., Papenfuss, A.T., Elso, C.M., Ashton, M.P., Quirk, F., Phipson, B., Bahlo, M., Speed, T.P., et al. (2010a). A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility. Genome Res 20, 1629-1638.
8 L6 s' S- p5 t3 Y3 J* JTan, I.K.L., Mackin, L., Wang, N., Papenfuss, A.T., Elso, C.M., Ashton, M.P., Quirk, F., Phipson, B., Bahlo, M., Speed, T.P., et al. (2010b). A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility. Genome Research 20, 1629-1638.
& {9 O9 b) |3 |Tan, K., Kajino, K., Momose, S., Masaoka, A., Sasahara, K., Shiomi, K., Izumi, H., Abe, M., Ohtsuji, N., Wang, T., et al. (2010c). Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter. Hum Pathol 41, 1330-1338.
+ V9 J- \' Y8 o  H5 r) YTang, H., and Goldberg, E. (2009). Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation. J Androl 30, 157-167.
9 F5 Z1 E6 i/ y2 t1 ^! c# kTao, L., Li, Y., Wang, W., Kramer, P.M., Gunning, W.T., Lubet, R.A., Steele, V.E., and Pereira, M.A. (2002). Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors. Mol Carcinog 35, 93-102.
2 A( U, H7 M  uTao, M.H., Marian, C., Nie, J., Ambrosone, C., Krishnan, S.S., Edge, S.B., Trevisan, M., Shields, P.G., and Freudenheim, J.L. (2011). Body mass and DNA promoter methylation in breast tumors in the Western New York Exposures and Breast Cancer Study. Am J Clin Nutr.+ O9 w- i( [& R6 j4 Z
Tenney, K., Gerber, M., Ilvarsonn, A., Schneider, J., Gause, M., Dorsett, D., Eissenberg, J.C., and Shilatifard, A. (2006). Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A 103, 11970-11974.
$ K& z* J0 p  y3 CTessema, M., Langer, F., Dingemann, J., Ganser, A., Kreipe, H., and Lehmann, U. (2003). Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML). Leukemia 17, 910-918./ @5 x7 X+ t8 r0 j4 C
Thornton, A.A., Owen, J.E., Kernstine, K., Koczywas, M., Grannis, F., Cristea, M., Reckamp, K., and Stanton, A.L. (2011). Predictors of finding benefit after lung cancer diagnosis. Psychooncology.& i/ y5 |$ N8 U/ n- T
Thorvaldsen, J.L., Fedoriw, A.M., Nguyen, S., and Bartolomei, M.S. (2006). Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus. Mol Cell Biol 26, 1245-1258.$ G" e( _0 B/ G, J4 z% s3 M& w
Tian, K., Wang, Y., Huang, Y., Sun, B., Li, Y., and Xu, H. (2008a). Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression. BMC Cancer 8, 327.
) q: L0 i; W1 o0 R1 y% sTian, L., Suzuki, M., Nakajima, T., Kubo, R., Sekine, Y., Shibuya, K., Hiroshima, K., Nakatani, Y., Fujisawa, T., and Yoshino, I. (2008b). Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer: association with prognosis, PTGER2 expression, and epidermal growth factor receptor mutation. Cancer 113, 1396-1403.1 ?+ O' r8 w& b/ I3 y" G
Tian, Z.X., Yu, Y.J., Lin, F., Yu, Y.S., SanMiguel, P.J., Wing, R.A., McCouch, S.R., Ma, J.X., and Jackson, S.A. (2011). Exceptional lability of a genomic complex in rice and its close relatives revealed by interspecific and intraspecific comparison and population analysis. BMC Genomics 12, -.0 ]2 R6 I- @9 w
Tomita, T., and Kimura, S. (2008). Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression. Bmc Molecular Biology 9, 5.% J- N2 v8 f1 \: O; j$ Q1 M
Torng, P.L., Lin, C.W., Chan, M.W., Yang, H.W., Huang, S.C., and Lin, C.T. (2009). Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma. Mol Cancer 8, 120.
3 [& O6 T. S1 v6 @* s+ zToshiyuki, N., and Ichiro, M. (2004). Molecular mechanisms regulating cell type specific expression of BMP/RA Inducible Neural-specific Protein-1 that suppresses cell cycle progression: roles of NRSF/REST and DNA methylation. Brain Res Mol Brain Res 125, 47-59.
, D2 W$ N/ i+ H- }2 k7 f1 LTreilleux, I., Chapot, B., Goddard, S., Pisani, P., Angele, S., and Hall, J. (2007). The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase. Histopathology 51, 63-69.# P+ |5 |6 W# M- o) ]1 }+ o
Trombetta, B., Cruciani, F., Underhill, P.A., Sellitto, D., and Scozzari, R. (2010). Footprints of X-to-Y Gene Conversion in Recent Human Evolution. Molecular Biology and Evolution 27, 714-725.
4 D! X) \9 v' `! e. v2 G3 H" FTsai, I.J., Burt, A., and Koufopanou, V. (2010). Conservation of recombination hotspots in yeast. Proceedings of the National Academy of Sciences of the United States of America 107, 7847-7852.
* ?/ N5 M' R/ d5 U2 BTsang, D.P., and Cheng, A.S. (2011). Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2. J Gastroenterol Hepatol 26, 19-27." N5 v( e7 ]$ ~; P( o/ R
Tsujiuchi, T., Sugata, E., Masaoka, T., Onishi, M., Fujii, H., Shimizu, K., and Honoki, K. (2007). Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. Cancer Sci 98, 943-948.
1 P; D0 F" ]- v9 Q7 f, {Tugume, A.K., Cuellar, W.J., Mukasa, S.B., and Valkonen, J.P.T. (2010). Molecular genetic analysis of virus isolates from wild and cultivated plants demonstrates that East Africa is a hotspot for the evolution and diversification of Sweet potato feathery mottle virus. Molecular Ecology 19, 3139-3156.
  K# f1 f% H1 {+ @- ^3 [9 O3 C' LTurner, D.J., Miretti, M., Rajan, D., Fiegler, H., Carter, N.P., Blayney, M.L., Beck, S., and Hurles, M.E. (2008). Germline rates of de novo meiotic deletions and duplications causing several genomic disorders. Nature Genetics 40, 90-95.
/ \$ K6 P' \9 d# u( Z- h  f" jTurner, J.G., Gump, J.L., Zhang, C., Cook, J.M., Marchion, D., Hazlehurst, L., Munster, P., Schell, M.J., Dalton, W.S., and Sullivan, D.M. (2006). ABCG2 expression, function, and promoter methylation in human multiple myeloma. Blood 108, 3881-3889.% l' P! T% a% [
Tycko, B. (2010). Allele-specific DNA methylation: beyond imprinting. Hum Mol Genet 19, R210-220.
* M# l6 a9 g! p+ l+ W3 S. }Ubeda, F., and Wilkins, J.F. (2011). The Red Queen theory of recombination hotspots. Journal of Evolutionary Biology 24, 541-553.
, {" l. D" b$ Y) `* |; T, rUccella, S., Cerutti, R., Placidi, C., Marchet, S., Carnevali, I., Bernasconi, B., Proserpio, I., Pinotti, G., Tibiletti, M.G., Furlan, D., et al. (2009). MGMT methylation in diffuse large B-cell lymphoma: validation of quantitative methylation-specific PCR and comparison with MGMT protein expression. J Clin Pathol 62, 715-723.  J+ g, n2 ^& L) s
Utikal, J., Gratchev, A., Muller-Molinet, I., Oerther, S., Kzhyshkowska, J., Arens, N., Grobholz, R., Kannookadan, S., and Goerdt, S. (2006). The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation. Int J Cancer 119, 2287-2293.
& \( X8 G, f$ z3 w" P; zUtriainen, P., Liu, J., Kuulasmaa, T., and Voutilainen, R. (2006). Inhibition of DNA methylation increases follistatin expression and secretion in the human adrenocortical cell line NCI-H295R. J Endocrinol 188, 305-310.
0 i& c% H' [8 Y" k6 `van der Drift, M., Prinsen, C., Knuiman, J., Janssen, J., Dekhuijzen, P.N., and Thunnissen, E. (2011). Diagnosing peripheral lung cancer: the additional value of RASSF1A methylation and KRAS mutation analyses in washings in non-diagnostic bronchoscopy. Chest.
" c& v' P7 d2 R1 |van der Linden, I.J., Heil, S.G., van Egmont Petersen, M., van Straaten, H.W., den Heijer, M., and Blom, H.J. (2008). Inhibition of methylation and changes in gene expression in relation to neural tube defects. Birth Defects Res A Clin Mol Teratol 82, 676-683.
4 V9 H7 f/ U& @2 m! Z- f- _van der Velden, P.A., Zuidervaart, W., Hurks, M.H., Pavey, S., Ksander, B.R., Krijgsman, E., Frants, R.R., Tensen, C.P., Willemze, R., Jager, M.J., et al. (2003). Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. Int J Cancer 106, 472-479.
& k% c- ~# F2 U- S8 o/ x1 u! i. vVandin, F., Upfal, E., and Raphael, B.J. (2011). De novo discovery of mutated driver pathways in cancer. Genome Res.
1 B9 ~4 a- ^. k5 G% ~# KVerma, M., and Manne, U. (2006). Genetic and epigenetic biomarkers in cancer diagnosis and identifying high risk populations. Crit Rev Oncol Hematol 60, 9-18.
" Z" y8 c* p& W: |, ]Viana-Pereira, M., Almeida, I., Sousa, S., Mahler-Araujo, B., Seruca, R., Pimentel, J., and Reis, R.M. (2009). Analysis of microsatellite instability in medulloblastoma. Neuro-Oncology 11, 458-467.
6 R$ B; e& l. sVincent, A., Omura, N., Hong, S.M., Jaffe, A., Eshleman, J., and Goggins, M. (2011). Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma. Clin Cancer Res 17, 4341-4354.& ?, A. w' g# X# e2 w
Visser, R., Shimokawa, O., Harada, N., Niikawa, N., and Matsumoto, N. (2005). Non-hotspot-related breakpoints of common deletions in Sotos syndrome are located within destabilised DNA regions. Journal of Medical Genetics 42, -.- f7 q* ]" ]: v
Vivekanandan, P., Thomas, D., and Torbenson, M. (2009). Methylation regulates hepatitis B viral protein expression. Journal of Infectious Diseases 199, 1286-1291.3 c0 l' ~# }% \. e9 e5 U
Volodin, A.A., and Camerini-Otero, R.D. (2002). Influence of DNA sequence on the positioning of RecA monomers in RecA-DNA cofilaments. Journal of Biological Chemistry 277, 1614-1618.) u# w0 b& m, \5 e
Voso, M.T., Fabiani, E., Piciocchi, A., Matteucci, C., Brandimarte, L., Finelli, C., Pogliani, E., Angelucci, E., Fioritoni, G., Musto, P., et al. (2011). Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-Azacytidine. Leukemia.
( s" }/ G% E5 w& EWagner, C.R., Kuervers, L., Baillie, D.L., and Yanowitz, J.L. (2010). xnd-1 regulates the global recombination landscape in Caenorhabditis elegans. Nature 467, 839-U103.
, D7 B' t1 ^, d3 HWahls, W.P., and Davidson, M.K. (2008). Low-copy episomal vector pFY20 and high-saturation coverage genomic libraries for the fission yeast Schizosaccharomyces pombe. Yeast 25, 643-650.- N. I$ Y* f& X6 j; W$ E' S1 R
Wali, A., Srinivasan, R., Shabnam, M.S., Majumdar, S., Joshi, K., and Behera, D. (2006). Loss of fragile histidine triad gene expression in advanced lung cancer is consequent to allelic loss at 3p14 locus and promoter methylation. Molecular Cancer Research 4, 93-99.
/ a- K9 R9 j) PWalker, P.R., Calzascia, T., Schnuriger, V., Chalmers, D., Saas, P., and Dietrich, P.Y. (2000). Loss of Fas (CD95/APO-1) expression by antigen-specific cytotoxic T cells is reversed by inhibiting DNA methylation. Cellular Immunology 206, 51-58.0 n, u2 B1 ?3 j% S
Wan, X., Weng, J., Zhai, H., Wang, J., Lei, C., Liu, X., Guo, T., Jiang, L., Su, N., and Wan, J. (2008a). Quantitative trait loci (QTL) analysis for rice grain width and fine mapping of an identified QTL allele gw-5 in a recombination hotspot region on chromosome 5. Genetics 179, 2239-2252.( n& t2 T9 r# V9 Q7 u
Wan, X.Y., Weng, J.F., Zhai, H.Q., Wang, J.K., Lei, C.L., Liu, X.L., Guo, T., Jiang, L., Su, N., and Wan, J.M. (2008b). Quantitative trait loci (QTL) analysis for rice grain width and fine mapping of an identified QTL allele gw-5 in a recombination hotspot region on chromosome 5. Genetics 179, 2239-2252.0 v$ P; Z& D$ o% k  l% t; I
Wang, C., Horiuchi, A., Imai, T., Ohira, S., Itoh, K., Nikaido, T., Katsuyama, Y., and Konishi, I. (2004a). Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene. J Pathol 202, 215-223.
0 X" v! E7 u8 Q, ]0 o" u' b  PWang, H., Hao, B., Zhou, K., Chen, X., Wu, S., Zhou, G., Zhu, Y., and He, F. (2004b). Linkage disequilibrium and haplotype architecture for two ABC transporter genes (ABCC1 and ABCG2) in Chinese population: Implications for pharmacogenomic association studies. Annals of Human Genetics 68, 563-573.5 Z# _# j7 w/ z3 h! t: \
Wang, H.R., Hsieh, C.Y., Twu, Y.C., and Yu, L.C. (2008a). Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status. Glycobiology 18, 104-113.
: V! h% Q1 ^* x: K% l' EWang, J., Klysik, E., Sood, S., Johnson, R.L., Wehrens, X.H., and Martin, J.F. (2010a). Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A 107, 9753-9758.
+ [5 B6 ?! l8 ~' U$ rWang, J., Walsh, G., Liu, D.D., Lee, J.J., and Mao, L. (2006a). Expression of Delta DNMT3B variants and its association with promoter methylation of p16 and RASSF1A in primary non-small cell lung cancer. Cancer Res 66, 8361-8366.
; y8 N$ C, b" T8 U' i5 YWang, L.H., Choi, Y.L., Hua, X.Y., Shin, Y.K., Song, Y.J., Youn, S.J., Yun, H.Y., Park, S.M., Kim, W.J., Kim, H.J., et al. (2006b). Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions. Mod Pathol 19, 675-683.
4 t; p# m3 s5 }( f2 A7 A# [Wang, M., Rada, C., and Neuberger, M.S. (2010b). Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID. Journal of Experimental Medicine 207, 141-153.3 k1 C+ f- n3 D7 r; j' a1 f" m3 s& ^) W
Wang, M.X., Sun, S., Li, C.L., and Shen, X. (2011a). Distinctive mitochondrial genome of Calanoid copepod Calanus sinicus with multiple large non-coding regions and reshuffled gene order: Useful molecular markers for phylogenetic and population studies. BMC Genomics 12, -.6 k: C( |+ r6 K* h2 q9 J% u& G
Wang, X., Chao, L., Jin, G., Ma, G., Zang, Y., and Sun, J. (2009). Association between CpG island methylation of the WWOX gene and its expression in breast cancers. Tumour Biol 30, 8-14.% _: i7 c( w! d% N
Wang, X., Tryndyak, V., Apostolov, E.O., Yin, X., Shah, S.V., Pogribny, I.P., and Basnakian, A.G. (2008b). Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation. Cancer Lett 270, 132-143.
5 @. n/ W; L9 V4 i, uWang, Y., Fan, P.S., and Kahaleh, B. (2006c). Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 54, 2271-2279.
" i9 T/ D& K% R; GWang, Y., and Rannala, B. (2008). Bayesian inference of fine-scale recombination rates using population genomic data. Philosophical Transactions of the Royal Society B-Biological Sciences 363, 3921-3930.! }$ t0 w* O* G4 X$ K$ O( {( m
Wang, Y., and Rannala, B. (2009). Population genomic inference of recombination rates and hotspots. Proceedings of the National Academy of Sciences of the United States of America 106, 6215-6219.2 R2 L: D1 n' ~
Wang, Y.C., and Chen, B.S. (2011). A network-based biomarker approach for molecular investigation and diagnosis of lung cancer. BMC Med Genomics 4, 2.
1 h$ k7 ^0 p; S7 a! E5 N, z' |Wang, Y.C., Tang, F.Y., Chen, S.Y., Chen, Y.M., and Chiang, E.P. (2011b). Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation. Journal of Nutrition 141, 777-782.
& ^) x6 R7 ]0 W, yWang, Z., Xu, L., and He, F. (2010c). Embryo vitrification affects the methylation of the H19/Igf2 differentially methylated domain and the expression of H19 and Igf2. Fertil Steril 93, 2729-2733.
, D/ r; W) I" Y' o& }6 wWang, Z., Zhang, Y., Ramsahoye, B., Bowen, D., and Lim, S.H. (2004c). Sp17 gene expression in myeloma cells is regulated by promoter methylation. Br J Cancer 91, 1597-1603.
$ T8 H8 O" z. h! eWatanabe, Y., Numata, K., Murata, S., Osada, Y., Saito, R., Nakaoka, H., Yamamoto, N., Watanabe, K., Kato, H., Abe, K., et al. (2010). Genome-wide analysis of expression modes and DNA methylation status at sense-antisense transcript loci in mouse. Genomics 96, 333-341., f2 e% N+ I0 |$ ^
Webb, A.J., Berg, I.L., and Jeffreys, A. (2008). Sperm cross-over activity in regions of the human genome showing extreme breakdown of marker association. Proceedings of the National Academy of Sciences of the United States of America 105, 10471-10476.& p9 |0 E* }& U; N1 u7 O1 C# D
Webster, M.T., Smith, N.G., Hultin-Rosenberg, L., Arndt, P.F., and Ellegren, H. (2005). Male-driven biased gene conversion governs the evolution of base composition in human alu repeats. Mol Biol Evol 22, 1468-1474.5 }8 n5 D' D, Y  {1 ?/ o2 Y# W
Wehbe, H., Henson, R., Meng, F., Mize-Berge, J., and Patel, T. (2006). Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression. Cancer Res 66, 10517-10524.
. ]# V  J4 X* l0 `- W0 fWeng, J.F., Gu, S.H., Wan, X.Y., Gao, H., Guo, T., Su, N., Lei, C.L., Zhang, X., Cheng, Z.J., Guo, X.P., et al. (2008). Isolation and initial characterization of GW5, a major QTL associated with rice grain width and weight. Cell Research 18, 1199-1209.
5 X$ A$ F- u& H' p' jWeng, W., Yang, Q., Huang, M., Qiao, Y., Xie, Y., Yu, Y., jing, A., and Li, Z. (2011). c-Myc inhibits TP53INP1 expression via promoter methylation in esophageal carcinoma. Biochem Biophys Res Commun 405, 278-284.
" }' @1 Q3 A* D1 JWidschwendter, A., Muller, H.M., Hubalek, M.M., Wiedemair, A., Fiegl, H., Goebel, G., Mueller-Holzner, E., Marth, C., and Widschwendter, M. (2004). Methylation status and expression of human telomerase reverse transcriptase in ovarian and cervical cancer. Gynecol Oncol 93, 407-416.. S7 C/ z; `$ B% m! {
Wilkinson, S.T., Fernandez, D.R., Murphy, S.P., Braziel, R.M., Campo, E., Chan, W.C., Delabie, J., Gascoyne, R.D., Staudt, L.M., Jaffe, E.S., et al. (2009). Decreased major histocompatibility complex class II expression in diffuse large B-cell lymphoma does not correlate with CpG methylation of class II transactivator promoters III and IV. Leuk Lymphoma 50, 1875-1878.
7 N5 {+ a9 ^- F5 s; qWilson, M.E., Westberry, J.M., and Prewitt, A.K. (2008). Dynamic regulation of estrogen receptor-alpha gene expression in the brain: a role for promoter methylation? Front Neuroendocrinol 29, 375-385.
  X/ N8 W( M7 n. H- u- kWoloszynska-Read, A., Mhawech-Fauceglia, P., Yu, J., Odunsi, K., and Karpf, A.R. (2008). Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer. Clin Cancer Res 14, 3283-3290.
( k* i0 Q' _1 ~% a! Q* d, _' UWong, J.J., Hawkins, N.J., and Ward, R.L. (2007a). Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56, 140-148.
6 y0 n' p' l- L0 f0 }/ y% gWong, N.A., Britton, M.P., Choi, G.S., Stanton, T.K., Bicknell, D.C., Wilding, J.L., and Bodmer, W.F. (2004). Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. Proc Natl Acad Sci U S A 101, 574-579.0 o; h& I1 c) X6 w- R
Wong, T.S., Liu, X.B., Ng, R.W., Wei, W.I., and Yuen, A.P. (2007b). Re: Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesis. J Natl Cancer Inst 99, 1343-1344; author reply 1344.9 Q! Y% u  D! m9 m$ Y: n5 F1 b
Wong, W.K., Chen, K., and Shih, J.C. (2003). Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation. J Biol Chem 278, 36227-36235.
+ E5 |3 w" a- Z$ I7 |# rWrensch, M., Jenkins, R.B., Chang, J.S., Yeh, R.F., Xiao, Y., Decker, P.A., Ballman, K.V., Berger, M., Buckner, J.C., Chang, S., et al. (2009). Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet 41, 905-908.0 b. G+ F1 W* q
Wright, K., Brown, L., Brown, G., Casson, P., and Brown, S. (2011). Microarray assessment of methylation in individual mouse blastocyst stage embryos shows that in vitro culture may have widespread genomic effects. Human Reproduction.9 M+ z" F3 |; b  ^% B: w
Wright, K.D., and Gilbertson, R.J. (2010). To infinium, and beyond! Cancer Cell 17, 419-420.
" h; m: P& N8 K2 kWu, H., D'Alessio, A.C., Ito, S., Wang, Z., Cui, K., Zhao, K., Sun, Y.E., and Zhang, Y. (2011). Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev 25, 679-684./ J# A3 B- m- X
Wu, J.M., Fackler, M.J., Halushka, M.K., Molavi, D.W., Taylor, M.E., Teo, W.W., Griffin, C., Fetting, J., Davidson, N.E., De Marzo, A.M., et al. (2008). Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res 14, 1938-1946.0 r( D) u: n" ?3 N2 c! B
Wu, S.C., Kallin, E.M., and Zhang, Y. (2010a). Role of H3K27 methylation in the regulation of lncRNA expression. Cell Res 20, 1109-1116.
' E  t: _1 L8 U5 YWu, Z.K., Getun, I.V., and Bois, P.R.J. (2010b). Anatomy of mouse recombination hot spots. Nucleic Acids Research 38, 2346-2354.
, a+ B/ l5 P+ Y' l" g) i( U7 BXi, S., Dyer, K.F., Kimak, M., Zhang, Q., Gooding, W.E., Chaillet, J.R., Chai, R.L., Ferrell, R.E., Zamboni, B., Hunt, J., et al. (2006). Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesis. J Natl Cancer Inst 98, 181-189.
. m- e+ {" M$ dXie, W., Han, S., Khan, M., and DeJong, J. (2002). Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation. J Biol Chem 277, 17765-17774.; i( D4 u; A+ d. t0 k# |" T
Xin, Y., Ge, Y., and Haghighi, F. (2011). Methyl-Analyzer - Whole Genome DNA Methylation Profiling. Bioinformatics.
$ ^& q) c! U  CXing, C., Wang, Q.F., Li, B., Tian, H., Ni, Y., Yin, S., and Li, G. (2010). Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning. Chem Biol Interact 184, 306-309.3 Q3 R8 c+ g/ W5 n* z
Xing, J., Stewart, D.J., Gu, J., Lu, C., Spitz, M.R., and Wu, X. (2008). Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. Br J Cancer 98, 1716-1722.! c& q5 T3 ?; n, L
Xiong, J., and Epstein, R.J. (2009). Growth inhibition of human cancer cells by 5-aza-2'-deoxycytidine does not correlate with its effects on INK4a/ARF expression or initial promoter methylation status. Mol Cancer Ther 8, 779-785.5 S) e, Z9 d* R8 a4 f
Xu, J. (2005). Age-related changes in Usp9x protein expression and DNA methylation in mouse brain. Brain Res Mol Brain Res 140, 17-24.: i, W% d1 C+ \  E3 w( |
Xu, J., and Andreassi, M. (2011). Reversible histone methylation regulates brain gene expression and behavior. Hormones and Behavior 59, 383-392.
0 J- Y( x; i/ B! y4 r/ K2 }% RXu, L., Czito, B.G., and Willett, C.G. (2010). Epigenetic markers in rectal cancer. Clin Cancer Res 16, 2699-2701.
% ^2 Y. S* c, n9 UYadav, N., Lee, J., Kim, J., Shen, J., Hu, M.C., Aldaz, C.M., and Bedford, M.T. (2003). Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A 100, 6464-6468.
* f; G6 A: D) D% Y. IYakushiji, N., Suzuki, M., Satoh, A., Sagai, T., Shiroishi, T., Kobayashi, H., Sasaki, H., Ide, H., and Tamura, K. (2007). Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibians. Dev Biol 312, 171-182.
# [" x2 B0 x% VYamada, N., Hamada, T., Goto, M., Tsutsumida, H., Higashi, M., Nomoto, M., and Yonezawa, S. (2006). MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. Int J Cancer 119, 1850-1857.: A& P' O) ^% T* O: b2 J
Yamada, N., Nishida, Y., Tsutsumida, H., Hamada, T., Goto, M., Higashi, M., Nomoto, M., and Yonezawa, S. (2008). MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells. Cancer Res 68, 2708-2716.+ [" k2 L# F, D1 ~" Q- \
Yamada, T., Mizuno, K., Hirota, K., Kon, N., Wahls, W.P., Hartsuiker, E., Murofushi, H., Shibata, T., and Ohta, K. (2004). Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J 23, 1792-1803.
" g/ _8 a2 q9 x. Q4 \Yamamoto, Y., Gesta, S., Lee, K.Y., Tran, T.T., Saadatirad, P., and Kahn, C.R. (2010). Adipose depots possess unique developmental gene signatures. Obesity (Silver Spring) 18, 872-878./ Z; R# C' c' n- F- {( P: T8 q
Yan, C., and Boyd, D.D. (2006). Histone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expression. Mol Cell Biol 26, 6357-6371.1 |- A) \8 N' s" L, ?" [
Yandeau-Nelson, M.D., Zhou, Q., Yao, H., Xu, X.J., Nikolau, B.J., and Schnable, P.S. (2005). MuDR transposase increases the frequency of meiotic crossovers in the vicinity of a Mu insertion in the maize a1 gene. Genetics 169, 917-929.; G, }7 V% k8 f" F* ?/ v
Yang, H.J., To, K.H., Aguila, S.J., and Miller, J.H. (2006). Metagenomic DNA fragments that affect Escherichia coli mutational pathways. Molecular Microbiology 61, 960-977.9 B. \4 p' W) v
Yang, I.C., Yang, S.K., Park, C.W., and Chung, J.H. (2000). De novo methylation at intronic CpG islands of Igf2r is associated with decreased expression of antisense RNA in aged mice. Biochem Biophys Res Commun 274, 722-726.- W1 y+ F' f- w# Q* Q5 r2 K
Yang, J., Xi, Q.Y., Deng, R.Q., Wang, J.W., Hou, J.L., and Wang, X.Z. (2007). Identification of interspecies recombination among Hepadnaviruses infecting cross-species hosts. Journal of Medical Virology 79, 1741-1750.
: o7 }1 X- j4 o/ z4 {# `Yang, M.Y., Liu, T.C., Chang, J.G., Lin, P.M., and Lin, S.F. (2003). JunB gene expression is inactivated by methylation in chronic myeloid leukemia. Blood 101, 3205-3211.
* D, M" S3 Y. _4 \) U& B* jYang, N., Coukos, G., and Zhang, L. (2008). MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatment. Int J Cancer 122, 963-968.
5 [) _7 a# U7 x. f1 \% p- JYang, X., Zheng, J., Qu, L., Chen, S., Li, J., Xu, G., and Yang, N. (2011). Methylation status of cMHM and expression of sex-specific genes in adult sex-reversed female chickens. Sex Dev 5, 147-154.; v$ R! q& `, t& [
Yang, Z., Wang, Y., Fang, J., Chen, F., Liu, J., and Wu, J. (2010). Expression and aberrant promoter methylation of Wnt inhibitory factor-1 in human astrocytomas. J Exp Clin Cancer Res 29, 26.
1 p& l1 m5 [% P) Z# EYatabe, Y., Mitsudomi, T., and Takahashi, T. (2004). Maspin expression in normal lung and non-small-cell lung cancers: cellular property-associated expression under the control of promoter DNA methylation. Oncogene 23, 4041-4049.5 E0 d8 I, D! U  i' Z8 h8 H$ U, d4 e8 C
Ye, M., Xia, B., Guo, Q., Zhou, F., and Zhang, X. (2007). Association of diminished expression of RASSF1A with promoter methylation in primary gastric cancer from patients of central China. BMC Cancer 7, 120.
6 q7 l! @4 M3 A  [3 xYeadon, P.J., Bowring, F.J., and Catcheside, D.E. (2004a). Alleles of the hotspot cog are codominant in effect on recombination in the his-3 region of Neurospora. Genetics 167, 1143-1153.
1 I% `. e4 I: Y8 NYeadon, P.J., Bowring, F.J., and Catcheside, D.E.A. (2004b). Alleles of the hotspot cog are codominant in effect on recombination in the his-3 region of neurospora. Genetics 167, 1143-1153.
! }0 |1 ~# T! F# o6 D8 l( V8 NYeager, M., Orr, N., Hayes, R.B., Jacobs, K.B., Kraft, P., Wacholder, S., Minichiello, M.J., Fearnhead, P., Yu, K., Chatterjee, N., et al. (2007). Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nature Genetics 39, 645-649.
8 h: W  o( n! \' x$ z+ J! rYeeles, J.T.P., Gwynn, E.J., Webb, M.R., and Dillingham, M.S. (2011). The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain. Nucleic Acids Research 39, 2271-2285.- p$ b/ Q# \% @: N
Yi, S.J., and Li, W.H. (2005). Molecular evolution of recombination hotspots and highly recombining pseudoautosomal regions in hominoids. Molecular Biology and Evolution 22, 1223-1230." {9 u5 ~6 h3 t  U3 z
Yin, D., Xie, D., Hofmann, W.K., Miller, C.W., Black, K.L., and Koeffler, H.P. (2002). Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors. Oncogene 21, 8372-8378.
* \5 w1 R, D4 c7 {Yip, S., Miao, J., Cahill, D.P., Iafrate, A.J., Aldape, K., Nutt, C.L., and Louis, D.N. (2009). MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance. Clin Cancer Res 15, 4622-4629.4 Z  q5 c8 S4 m* d; v0 ]4 x0 g+ z
Yu, L., Gu, S., Alappat, S., Song, Y., Yan, M., Zhang, X., Zhang, G., Jiang, Y., Zhang, Z., Zhang, Y., et al. (2005). Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development 132, 4397-4406.+ u" d& @( i9 V8 D5 S8 v$ `+ _
Yuan, Y., Liu, H., Sahin, A., and Dai, J.L. (2005). Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness. Int J Cancer 113, 654-659.  F' ~# d* Z' B" O$ n) F
Yuan, Y., Qian, Z.R., Sano, T., Asa, S.L., Yamada, S., Kagawa, N., and Kudo, E. (2008). Reduction of GSTP1 expression by DNA methylation correlates with clinicopathological features in pituitary adenomas. Mod Pathol 21, 856-865.5 w0 T# M' m/ H
Zawadzki, C., Chatelain, N., Delestre, M., Susen, S., Quesnel, B., Juthier, F., Jeanpierre, E., Azzaoui, R., Corseaux, D., Breyne, J., et al. (2009). Tissue factor pathway inhibitor-2 gene methylation is associated with low expression in carotid atherosclerotic plaques. Atherosclerosis 204, e4-14.
- g% S! A3 y6 f  _' H( oZelko, I.N., Mueller, M.R., and Folz, R.J. (2010). CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression. Free Radic Biol Med 48, 895-904.
, `# b5 M' e% I+ {9 |Zempleni, J., Chew, Y.C., Hassan, Y.I., and Wijeratne, S.S.K. (2008). Epigenetic regulation of chromatin structure and gene function by biotin: are biotin requirements being met? Nutrition Reviews 66, S46-S48., s6 M; Y6 ?- d# ?+ d; X5 |
Zeng, J., and Yi, S.V. (2010). DNA methylation and genome evolution in honeybee: gene length, expression, functional enrichment covary with the evolutionary signature of DNA methylation. Genome Biol Evol 2, 770-780.; L: Q- ~# v: ]% k* y
Zhang, C., Guo, X., Zhang, L., Lu, Z., Ma, N., Cheng, Y., Shen, F., Zhang, B., Wu, M., and Wei, L. (2008a). Methylation-related silencing of p14ARF gene correlates with telomerase activity and mRNA expression of human telomerase reverse transcriptase in hepatocellular carcinoma. J Surg Oncol 98, 462-468.
( A: b( [' U7 S1 \1 H" tZhang, D., Ai, D., Tanaka, H., Hammock, B.D., and Zhu, Y. (2010a). DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism. Biochim Biophys Acta 1799, 659-667.
% }% a6 U8 M$ C: R, M0 lZhang, D., Bai, Y., Wang, Y., Luo, J., Ge, Q., Qiao, Y., Jia, C., and Lu, Z. (2008b). Detailed methylation patterns and protein expression profiles of MGMT in colorectal carcinoma surgical margins. Clin Biochem 41, 19-25.( d3 o8 N* x& t( F% T  ?1 _
Zhang, H., Zhang, S., Cui, J., Zhang, A., Shen, L., and Yu, H. (2008c). Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer. Aust N Z J Obstet Gynaecol 48, 505-509.
2 e" C% n; ~2 y  eZhang, J., Li, F., Li, J., Zhang, M.Q., and Zhang, X.G. (2004a). Evidence and characteristics of putative human alpha recombination hotspots. Human Molecular Genetics 13, 2823-2828.
9 Y) X2 C0 c2 r; p% qZhang, K., Zhang, R., Li, X., Yin, G., Niu, X., and Hou, R. (2007). The mRNA expression and promoter methylation status of the p16 gene in colony-forming cells with high proliferative potential in patients with psoriasis. Clin Exp Dermatol 32, 702-708.
2 X; M; S# {4 X0 n# o! CZhang, M., Xu, C., von Wettstein, D., and Liu, B. (2011a). Tissue-Specific Differences in Cytosine Methylation and their Association with Differential Gene Expression in Sorghum bicolar. Plant Physiol.0 i9 R* s8 V9 ^7 ~/ h4 F
Zhang, P., Wang, J., Gao, W., Yuan, B.Z., Rogers, J., and Reed, E. (2004b). CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer. Mol Cancer 3, 14.
& I( \8 t. Z7 E  c& [, uZhang, X., Song, Z., Xu, J., and Ma, Z. (2011b). Improving the NQO1 Inducing Activities of Phenolic Acids from Radix Salvia miltiorrhiza: a Methylation Strategy. Chem Biol Drug Des.
9 f( |. E9 b1 }1 K: PZhang, X., Wu, M., Xiao, H., Lee, M.T., Levin, L., Leung, Y.K., and Ho, S.M. (2010b). Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. Prostate 70, 765-776.
6 p) f( r+ b5 p( k! Y* yZhang, Y., Rohde, C., Reinhardt, R., Voelcker-Rehage, C., and Jeltsch, A. (2009). Non-imprinted allele-specific DNA methylation on human autosomes. Genome Biol 10, R138.3 M% H$ {, \) l, D5 \
Zhang, Z., Karam, J., Frenkel, E., Sagalowsky, A., and Hsieh, J.T. (2006). The application of epigenetic modifiers on the treatment of prostate and bladder cancer. Urol Oncol 24, 152-160.5 D2 G$ h. Z0 Y5 {; n
Zhao, C., Lam, E.W., Sunters, A., Enmark, E., De Bella, M.T., Coombes, R.C., Gustafsson, J.A., and Dahlman-Wright, K. (2003). Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene 22, 7600-7606.; \( O& X' Q8 A
Zhao, Z., Yu, Y., Meyer, D., Wu, C., and Shen, W.H. (2005). Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36. Nat Cell Biol 7, 1256-1260.
2 t2 F, z% d" P  V6 _4 kZheng, J., Khil, P.P., Camerini-Otero, R.D., and Przytycka, T.M. (2010). Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome. Genome Biology 11, -.
* |( o) p: s2 b! fZheng, S.L., Stevens, V.L., Wiklund, F., Isaacs, S.D., Sun, J.L., Smith, S., Pruett, K., Wiley, K.E., Kim, S.T., Zhu, Y., et al. (2009). Two Independent Prostate Cancer Risk-Associated Loci at 11q13. Cancer Epidemiology Biomarkers & Prevention 18, 1815-1820.
( ]& x3 n; B! `! y  t3 r  S  }Zheng, Y.G., Wu, J., Chen, Z., and Goodman, M. (2008). Chemical regulation of epigenetic modifications: opportunities for new cancer therapy. Med Res Rev 28, 645-687.# W1 n! K# _4 c( Y3 R% n
Zhou, T., Weng, J.H., Sun, X., and Lu, Z.H. (2006). Support vector machine for classification of meiotic recombination hotspots and coldspots in Saccharomyces cerevisiae based on codon composition. BMC Bioinformatics 7, -.- d6 l; }( _/ B3 Y9 ]& H
Zhou, X.C., Dowdy, S.C., Podratz, K.C., and Jiang, S.W. (2007). Epigenetic considerations for endometrial cancer prevention, diagnosis and treatment. Gynecol Oncol 107, 143-153.3 Q+ k! u0 Z6 s" W9 X
Zou, B., Chim, C.S., Zeng, H., Leung, S.Y., Yang, Y., Tu, S.P., Lin, M.C., Wang, J., He, H., Jiang, S.H., et al. (2006). Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. Gastroenterology 131, 1835-1843.
  e' N5 ^9 i7 P3 A4 C  SZsurka, G., Kudina, T., Peeva, V., Hallmann, K., Elger, C.E., Khrapko, K., and Kunz, W.S. (2010). Distinct patterns of mitochondrial genome diversity in bonobos (Pan paniscus) and humans. Bmc Evolutionary Biology 10, -.
( f! t* M" L" ^' g8 e5 j+ A# R- PZuiverloon, T.C., Beukers, W., van der Keur, K.A., Munoz, J.R., Bangma, C.H., Lingsma, H.F., Eijkemans, M.J., Schouten, J.P., and Zwarthoff, E.C. (2011). A methylation assay for the detection of non-muscle-invasive bladder cancer (NMIBC) recurrences in voided urine. BJU Int.
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发表于 2012-1-23 21:25 |只看该作者
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楼主辛苦了!

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报纸
发表于 2012-1-23 21:58 |只看该作者
楼主辛苦了。能否把文章打包啊

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地板
发表于 2012-1-26 15:56 |只看该作者
of couse, happy to share them with anybody, i will rar them asap

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发表于 2012-1-31 18:58 |只看该作者
回复 Tlexander 的帖子  y' j. c0 G! L/ G/ F0 \0 I

- q! _8 q2 y/ O' }$ z+ O8 q  o  r很想问一下您那个图标上的徽章是什么?
6 C3 [% u0 H9 X; q- D谢谢!

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发表于 2012-2-2 11:50 |只看该作者
回复 embryonic12 的帖子6 G% E8 N- G; {! O& I
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复旦大学现代人类学实验室的徽标,欢迎交流

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发表于 2012-2-2 11:51 |只看该作者
回复 yuhaoze 的帖子
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& K$ e( O8 `( F可以,请看楼下的帖子

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发表于 2012-2-2 18:12 |只看该作者
我试了全部打包一起上传,结果总是无法上传成功
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