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From teratomas to embryonic stem cells: discovering pluripotency
5 B2 c1 r$ R6 u3 v; t+ X6 IPeter W. Andrews and Paul J. Gokhale
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Article bodyThis year marks the thirtieth anniversary since mouse embryonic stem (ES) cells were first isolated from blastocysts. This paved the way to the first targeted knockouts of genes in mice, which provided a crucial tool for studying mouse development and founded a new field of stem cell research. Today, researchers are able to generate induced pluripotent stem (iPS) cells from somatic cells, which might have important clinical applications.
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This Poster by Peter W. Andrews and Paul J. Gokhale provides a timeline overview of the history of pluripotency, starting from early studies of teratocarcinomas in 1954, which preceded the isolation of mouse and human ES cells, and ending with the generation of iPS cells. In doing so, it highlights how our understanding of the pluripotent state has evolved over almost 60 years.( w* U5 f3 B, k% M; l1 p
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The Poster is freely available thanks to support from Abcam
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