miRNA-操纵干细胞命运

热度 4已有 2061 次阅读 2011-5-18 21:08 |关键词:干细胞 style 命运

【转载】http://cmbi.bjmu.edu.cn/news/report/2009/ca_mirna.html

microRNA与干细胞

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用。

但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程。这里搜集了近年来一些microRNA与干细胞的文献，供大家参考。更多文献，请用相关关键词通过CMBI文献查询

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回复临床干细胞 2011-6-10 05:00: 仁兄，这篇文章中所说的Nature Stem Cell是什么杂志，找不到啊

回复 sunsong7 2011-6-10 09:09: 临床干细胞: 仁兄，这篇文章中所说的Nature Stem Cell是什么杂志，找不到啊
Nat Rev Mol Cell Biol. 2009 Feb;10(2):116-25.
MicroRNAs: key regulators of stem cells.
Gangaraju VK, Lin H.
SourceYale Stem Cell Center, Yale University School of Medicine, 10 Amistad Street, New Haven, Connecticut 06520-8002, USA.

Abstract
The hallmark of a stem cell is its ability to self-renew and to produce numerous differentiated cells. This unique property is controlled by dynamic interplays between extrinsic signalling, epigenetic, transcriptional and post-transcriptional regulations. Recent research indicates that microRNAs (miRNAs) have an important role in regulating stem cell self-renewal and differentiation by repressing the translation of selected mRNAs in stem cells and differentiating daughter cells. Such a role has been shown in embryonic stem cells, germline stem cells and various somatic tissue stem cells. These findings reveal a new dimension of gene regulation in controlling stem cell fate and behaviour.

PMID: 19165214 [PubMed - indexed for MEDLINE]

回复 sunsong7 2011-6-10 09:16: MicroRNAs as Regulators of Differentiation and Cell Fate Decisions
http://www.stemcell8.cn/thread-40007-1-1.html

MicroRNAs: key regulators of stem cells
http://www.stemcell8.cn/thread-40009-1-1.html

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